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Research Article

Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages

  • Moses T. Bility mail,

    moses_bility@med.unc.edu (MTB); lsu@med.unc.edu (LS)

    Affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Liang Cheng,

    Affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Zheng Zhang,

    Affiliation: Center of Infectious Disease, Beijing 302 Hospital, Beijing, China

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  • Yan Luan,

    Affiliations: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Department of Pathology, University of Chicago, Chicago, Illinois, United States of America

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  • Feng Li,

    Affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Liqun Chi,

    Affiliation: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Liguo Zhang,

    Affiliation: Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

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  • Zhengkun Tu,

    Affiliations: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Translational Medicine, Department of Surgery, Department of Medicine, the First Hospital, Jilin University, Changchun, Jilin, China

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  • Yanhang Gao,

    Affiliation: Department of Translational Medicine, Department of Surgery, Department of Medicine, the First Hospital, Jilin University, Changchun, Jilin, China

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  • Yangxin Fu,

    Affiliations: Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Department of Pathology, University of Chicago, Chicago, Illinois, United States of America

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  • Junqi Niu,

    Affiliation: Department of Translational Medicine, Department of Surgery, Department of Medicine, the First Hospital, Jilin University, Changchun, Jilin, China

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  • Fusheng Wang,

    Affiliation: Center of Infectious Disease, Beijing 302 Hospital, Beijing, China

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  • Lishan Su mail

    moses_bility@med.unc.edu (MTB); lsu@med.unc.edu (LS)

    Affiliations: Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, Department of Translational Medicine, Department of Surgery, Department of Medicine, the First Hospital, Jilin University, Changchun, Jilin, China

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  • Published: March 20, 2014
  • DOI: 10.1371/journal.ppat.1004032

About the Authors

Moses T. Bility, Liang Cheng, Yan Luan, Feng Li, Liqun Chi, Zhengkun Tu, Lishan Su
Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Zheng Zhang, Fusheng Wang
Center of Infectious Disease, Beijing 302 Hospital, Beijing, China
Yan Luan, Liguo Zhang, Yangxin Fu, Lishan Su
Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Yan Luan, Yangxin Fu
Department of Pathology, University of Chicago, Chicago, Illinois, United States of America
Zhengkun Tu, Yanhang Gao, Junqi Niu, Lishan Su
Department of Translational Medicine, Department of Surgery, Department of Medicine, the First Hospital, Jilin University, Changchun, Jilin, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MTB LZ LS. Performed the experiments: MTB LC ZZ YL FL LC ZT YG LZ. Analyzed the data: MTB LC ZZ ZT JN YF FW LS. Contributed reagents/materials/analysis tools: JN FW YF. Wrote the paper: MTB LC LS.