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Research Article

An Immunomics Approach to Schistosome Antigen Discovery: Antibody Signatures of Naturally Resistant and Chronically Infected Individuals from Endemic Areas

  • Soraya Gaze,

    Affiliations: Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, Queensland Tropical Health Alliance Laboratory, James Cook University, Cairns, Queensland, Australia, Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Centro de Pesquisas René Rachou, Instituto Fiocruz, Belo Horizonte, Minas Gerais, Brazil

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  • Patrick Driguez,

    Affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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  • Mark S. Pearson,

    Affiliation: Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, Queensland Tropical Health Alliance Laboratory, James Cook University, Cairns, Queensland, Australia

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  • Tiago Mendes,

    Affiliation: Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

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  • Denise L. Doolan,

    Affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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  • Angela Trieu,

    Affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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  • Donald P. McManus,

    Affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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  • Geoffrey N. Gobert,

    Affiliation: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

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  • Maria Victoria Periago,

    Affiliation: Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Centro de Pesquisas René Rachou, Instituto Fiocruz, Belo Horizonte, Minas Gerais, Brazil

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  • Rodrigo Correa Oliveira,

    Affiliation: Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Centro de Pesquisas René Rachou, Instituto Fiocruz, Belo Horizonte, Minas Gerais, Brazil

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  • Fernanda C. Cardoso,

    Affiliations: QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia, Institute for Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia

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  • Guilherme Oliveira,

    Affiliation: Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Centro de Pesquisas René Rachou, Instituto Fiocruz, Belo Horizonte, Minas Gerais, Brazil

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  • Rie Nakajima,

    Affiliation: University of California Irvine, Irvine, California, United States of America

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  • Al Jasinskas,

    Affiliation: University of California Irvine, Irvine, California, United States of America

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  • Chris Hung,

    Affiliation: University of California Irvine, Irvine, California, United States of America

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  • Li Liang,

    Affiliation: University of California Irvine, Irvine, California, United States of America

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  • Jozelyn Pablo,

    Affiliation: University of California Irvine, Irvine, California, United States of America

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  • Jeffrey M. Bethony,

    Affiliation: George Washington University, Washington, D.C., United States of America

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  • Philip L. Felgner,

    Affiliation: University of California Irvine, Irvine, California, United States of America

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  • Alex Loukas mail

    Alex.Loukas@jcu.edu.au

    Affiliation: Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, Queensland Tropical Health Alliance Laboratory, James Cook University, Cairns, Queensland, Australia

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  • Published: March 27, 2014
  • DOI: 10.1371/journal.ppat.1004033

About the Authors

Soraya Gaze, Mark S. Pearson, Alex Loukas
Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, Queensland Tropical Health Alliance Laboratory, James Cook University, Cairns, Queensland, Australia
Soraya Gaze, Maria Victoria Periago, Rodrigo Correa Oliveira, Guilherme Oliveira
Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Centro de Pesquisas René Rachou, Instituto Fiocruz, Belo Horizonte, Minas Gerais, Brazil
Patrick Driguez, Denise L. Doolan, Angela Trieu, Donald P. McManus, Geoffrey N. Gobert, Fernanda C. Cardoso
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
Tiago Mendes
Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Fernanda C. Cardoso
Institute for Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia
Rie Nakajima, Al Jasinskas, Chris Hung, Li Liang, Jozelyn Pablo, Philip L. Felgner
University of California Irvine, Irvine, California, United States of America
Jeffrey M. Bethony
George Washington University, Washington, D.C., United States of America

Corresponding Author

Email: Alex.Loukas@jcu.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SG JMB PLF PD DLD DPM AL. Performed the experiments: SG JMB MSP TM AT GNG FCC RN AJ JP MVP. Analyzed the data: SG PD MSP TM AT DLD GNG FCC RN CH LL JP JMB PLF AL. Contributed reagents/materials/analysis tools: RCO GO JMB PLF RN PD DPM GNG AJ JP AL. Wrote the paper: SG JMB MSP PLF AL.