Advertisement
Research Article

Large Scale RNAi Reveals the Requirement of Nuclear Envelope Breakdown for Nuclear Import of Human Papillomaviruses

  • Inci Aydin equal contributor,

    equal contributor Contributed equally to this work with: Inci Aydin, Susanne Weber

    Affiliations: Emmy-Noether Group: Virus Endocytosis, Institutes of Molecular Virology and Medical Biochemistry, ZMBE, University of Münster, Münster, Germany, Cluster of Excellence EXC1003, Cells in Motion, Münster, Germany

    X
  • Susanne Weber equal contributor,

    equal contributor Contributed equally to this work with: Inci Aydin, Susanne Weber

    Affiliations: Emmy-Noether Group: Virus Endocytosis, Institutes of Molecular Virology and Medical Biochemistry, ZMBE, University of Münster, Münster, Germany, Cluster of Excellence EXC1003, Cells in Motion, Münster, Germany

    X
  • Berend Snijder,

    Affiliation: Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

    X
  • Pilar Samperio Ventayol,

    Affiliations: Emmy-Noether Group: Virus Endocytosis, Institutes of Molecular Virology and Medical Biochemistry, ZMBE, University of Münster, Münster, Germany, Cluster of Excellence EXC1003, Cells in Motion, Münster, Germany

    X
  • Andreas Kühbacher,

    Affiliation: Institute of Biochemistry, ETH Zurich, Zurich, Switzerland

    X
  • Miriam Becker,

    Affiliations: Emmy-Noether Group: Virus Endocytosis, Institutes of Molecular Virology and Medical Biochemistry, ZMBE, University of Münster, Münster, Germany, Cluster of Excellence EXC1003, Cells in Motion, Münster, Germany

    X
  • Patricia M. Day,

    Affiliation: Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • John T. Schiller,

    Affiliation: Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Michael Kann,

    Affiliation: Laboratoire de Microbiologie Fondamentale et Pathogénicité, Université Bordeaux Segalen, Bordeaux, France

    X
  • Lucas Pelkmans,

    Affiliation: Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

    X
  • Ari Helenius,

    Affiliation: Institute of Biochemistry, ETH Zurich, Zurich, Switzerland

    X
  • Mario Schelhaas mail

    schelhaas@uni-muenster.de

    Affiliations: Emmy-Noether Group: Virus Endocytosis, Institutes of Molecular Virology and Medical Biochemistry, ZMBE, University of Münster, Münster, Germany, Cluster of Excellence EXC1003, Cells in Motion, Münster, Germany

    X
  • Published: May 29, 2014
  • DOI: 10.1371/journal.ppat.1004162

About the Authors

Inci Aydin, Susanne Weber, Pilar Samperio Ventayol, Miriam Becker, Mario Schelhaas
Emmy-Noether Group: Virus Endocytosis, Institutes of Molecular Virology and Medical Biochemistry, ZMBE, University of Münster, Münster, Germany
Inci Aydin, Susanne Weber, Pilar Samperio Ventayol, Miriam Becker, Mario Schelhaas
Cluster of Excellence EXC1003, Cells in Motion, Münster, Germany
Berend Snijder, Lucas Pelkmans
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland
Andreas Kühbacher, Ari Helenius
Institute of Biochemistry, ETH Zurich, Zurich, Switzerland
Patricia M. Day, John T. Schiller
Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Michael Kann
Laboratoire de Microbiologie Fondamentale et Pathogénicité, Université Bordeaux Segalen, Bordeaux, France

Corresponding Author

Email: schelhaas@uni-muenster.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IA SW BS LP AH MS. Performed the experiments: IA SW PSV AK MB MS. Analyzed the data: IA SW PSV AK MB MS. Contributed reagents/materials/analysis tools: PMD JTS MK. Wrote the paper: IA SW BS PSV PMD MB MK LP AH MS.