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Table of Contents: September 2013

COVER

The rise of coronaviruses

Image Credit: Richie Frieman
Issue Image

The emergence of the Middle East respiratory syndrome (MERS) coronavirus, ten years after the emergence of SARS coronavirus, demonstrates the importance of understanding the biology and pathogenesis of these viruses. This knowledge will aid in the development of countermeasure against these and other potentially emergent zoonotic coronaviruses. See Coleman, Frieman.

Pearls

Memory of Infections: An Emerging Role for Natural Killer Cells

Alexander Rölle, Julia Pollmann, Adelheid Cerwenka

Emerging and Emerged Pathogenic Candida Species: Beyond the Candida albicans Paradigm

Nicolas Papon, Vincent Courdavault, Marc Clastre, Richard J. Bennett

Innate Immune Sensing of Flaviviruses

Mehul S. Suthar, Sebastian Aguirre, Ana Fernandez-Sesma

Atomic Force Microscopy: A New Look at Pathogens

David Alsteens, Audrey Beaussart, Sofiane El-Kirat-Chatel, Ruby May A. Sullan, Yves F. Dufrêne

Emergence of the Middle East Respiratory Syndrome Coronavirus

Christopher M. Coleman, Matthew B. Frieman

Research Articles

Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice

Ilona Hauber, Helga Hofmann-Sieber, Jan Chemnitz, Danilo Dubrau, Janet Chusainow, Rolf Stucka, Philip Hartjen, Axel Schambach, Patrick Ziegler, Karl Hackmann, Evelin Schröck, Udo Schumacher, Christoph Lindner, Adam Grundhoff, Christopher Baum, Markus G. Manz, Frank Buchholz, Joachim Hauber

Sustained Autophagy Contributes to Measles Virus Infectivity

Clémence Richetta, Isabel P. Grégoire, Pauline Verlhac, Olga Azocar, Joël Baguet, Monique Flacher, Frédéric Tangy, Chantal Rabourdin-Combe, Mathias Faure

Host Adaptation Is Contingent upon the Infection Route Taken by Pathogens

Nelson E. Martins, Vitor G. Faria, Luis Teixeira, Sara Magalhães, Élio Sucena

Dual Analysis of the Murine Cytomegalovirus and Host Cell Transcriptomes Reveal New Aspects of the Virus-Host Cell Interface

Vanda Juranic Lisnic, Marina Babic Cac, Berislav Lisnic, Tihana Trsan, Adam Mefferd, Chitrangada Das Mukhopadhyay, Charles H. Cook, Stipan Jonjic, Joanne Trgovcich

Atomic Resolution Description of the Interaction between the Nucleoprotein and Phosphoprotein of Hendra Virus

Guillaume Communie, Johnny Habchi, Filip Yabukarski, David Blocquel, Robert Schneider, Nicolas Tarbouriech, Nicolas Papageorgiou, Rob W. H. Ruigrok, Marc Jamin, Malene Ringkjøbing Jensen, Sonia Longhi, Martin Blackledge

Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10

Kathryn A. K. Finton, Kevin Larimore, H. Benjamin Larman, Della Friend, Colin Correnti, Peter B. Rupert, Stephen J. Elledge, Philip D. Greenberg, Roland K. Strong

Inherited Prion Disease A117V Is Not Simply a Proteinopathy but Produces Prions Transmissible to Transgenic Mice Expressing Homologous Prion Protein

Emmanuel A. Asante, Jacqueline M. Linehan, Michelle Smidak, Andrew Tomlinson, Andrew Grimshaw, Asif Jeelani, Tatiana Jakubcova, Shyma Hamdan, Caroline Powell, Sebastian Brandner, Jonathan D. F. Wadsworth, John Collinge

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

Martin Marek, Srinivasaraghavan Kannan, Alexander-Thomas Hauser, Marina Moraes Mourão, Stéphanie Caby, Vincent Cura, Diana A. Stolfa, Karin Schmidtkunz, Julien Lancelot, Luiza Andrade, Jean-Paul Renaud, Guilherme Oliveira, Wolfgang Sippl, Manfred Jung, Jean Cavarelli, Raymond J. Pierce, Christophe Romier

Absence of Siglec-H in MCMV Infection Elevates Interferon Alpha Production but Does Not Enhance Viral Clearance

Franz Puttur, Catharina Arnold-Schrauf, Katharina Lahl, Gulhas Solmaz, Marc Lindenberg, Christian Thomas Mayer, Melanie Gohmert, Maxine Swallow, Christopher van Helt, Heike Schmitt, Lars Nitschke, Bart N. Lambrecht, Roland Lang, Martin Messerle, Tim Sparwasser

A New Class of Quorum Quenching Molecules from Staphylococcus Species Affects Communication and Growth of Gram-Negative Bacteria

Ya-Yun Chu, Mulugeta Nega, Martina Wölfle, Laure Plener, Stephanie Grond, Kirsten Jung, Friedrich Götz

The Suf Iron-Sulfur Cluster Synthesis Pathway Is Required for Apicoplast Maintenance in Malaria Parasites

Jolyn E. Gisselberg, Teegan A. Dellibovi-Ragheb, Krista A. Matthews, Gundula Bosch, Sean T. Prigge

Assisted Evolution Enables HIV-1 to Overcome a High TRIM5α-Imposed Genetic Barrier to Rhesus Macaque Tropism

Steven J. Soll, Sam J. Wilson, Sebla B. Kutluay, Theodora Hatziioannou, Paul D. Bieniasz

Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein

Nicholas Glanville, Gary R. Mclean, Bruno Guy, Valerie Lecouturier, Catherine Berry, Yves Girerd, Christophe Gregoire, Ross P. Walton, Rebecca M. Pearson, Tatiana Kebadze, Nicolas Burdin, Nathan W. Bartlett, Jeffrey W. Almond, Sebastian L. Johnston

Lymph Node Colonization Dynamics after Oral Salmonella Typhimurium Infection in Mice

Patrick Kaiser, Emma Slack, Andrew J. Grant, Wolf-Dietrich Hardt, Roland R. Regoes

Phosphoproteomic Analyses Reveal Signaling Pathways That Facilitate Lytic Gammaherpesvirus Replication

James A. Stahl, Shweta S. Chavan, Jeffrey M. Sifford, Veronica MacLeod, Daniel E. Voth, Ricky D. Edmondson, J. Craig Forrest

Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection

Eva Rothmeier, Gudrun Pfaffinger, Christine Hoffmann, Christopher F. Harrison, Heinrich Grabmayr, Urska Repnik, Mandy Hannemann, Stefan Wölke, Andreas Bausch, Gareth Griffiths, Annette Müller-Taubenberger, Aymelt Itzen, Hubert Hilbi

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

Rogier W. Sanders, Ronald Derking, Albert Cupo, Jean-Philippe Julien, Anila Yasmeen, Natalia de Val, Helen J. Kim, Claudia Blattner, Alba Torrents de la Peña, Jacob Korzun, Michael Golabek, Kevin de los Reyes, Thomas J. Ketas, Marit J. van Gils, C. Richter King, Ian A. Wilson, Andrew B. Ward, P. J. Klasse, John P. Moore

Epstein Barr Virus-Induced 3 (EBI3) Together with IL-12 Negatively Regulates T Helper 17-Mediated Immunity to Listeria monocytogenes Infection

Yeonseok Chung, Tomohide Yamazaki, Byung-Seok Kim, Yongliang Zhang, Joseph M. Reynolds, Gustavo J. Martinez, Seon Hee Chang, Hoyong Lim, Mark Birkenbach, Chen Dong

HTLV-1 bZIP Factor Induces Inflammation through Labile Foxp3 Expression

Nanae Yamamoto-Taguchi, Yorifumi Satou, Paola Miyazato, Koichi Ohshima, Masanori Nakagawa, Koko Katagiri, Tatsuo Kinashi, Masao Matsuoka

Inactivation of Intergenic Enhancers by EBNA3A Initiates and Maintains Polycomb Signatures across a Chromatin Domain Encoding CXCL10 and CXCL9

Marie L. Harth-Hertle, Barbara A. Scholz, Florian Erhard, Laura V. Glaser, Lars Dölken, Ralf Zimmer, Bettina Kempkes

Acute Neonatal Infections ‘Lock-In’ a Suboptimal CD8+ T Cell Repertoire with Impaired Recall Responses

Brian D. Rudd, Vanessa Venturi, Norah L. Smith, Kito Nzingha, Emily L. Goldberg, Gang Li, Janko Nikolich-Zugich, Miles P. Davenport

Aggressive Chemotherapy and the Selection of Drug Resistant Pathogens

Silvie Huijben, Andrew S. Bell, Derek G. Sim, Danielle Tomasello, Nicole Mideo, Troy Day, Andrew F. Read

Methionine Biosynthesis in Staphylococcus aureus Is Tightly Controlled by a Hierarchical Network Involving an Initiator tRNA-Specific T-box Riboswitch

Sonja M. K. Schoenfelder, Gabriella Marincola, Tobias Geiger, Christiane Goerke, Christiane Wolz, Wilma Ziebuhr

Rapid Sequential Spread of Two Wolbachia Variants in Drosophila simulans

Peter Kriesner, Ary A. Hoffmann, Siu F. Lee, Michael Turelli, Andrew R. Weeks

Human Cytomegalovirus Gene UL76 Induces IL-8 Expression through Activation of the DNA Damage Response

Helena Costa, Rute Nascimento, John Sinclair, Robert Michael Evans Parkhouse

Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

Fei Liu, Matthew Campagna, Yonghe Qi, Xuesen Zhao, Fang Guo, Chunxiao Xu, Sichen Li, Wenhui Li, Timothy M. Block, Jinhong Chang, Ju-Tao Guo

The Crystal Structure and RNA-Binding of an Orthomyxovirus Nucleoprotein

Wenjie Zheng, John Olson, Vikram Vakharia, Yizhi Jane Tao

Small RNA sX13: A Multifaceted Regulator of Virulence in the Plant Pathogen Xanthomonas

Cornelius Schmidtke, Ulrike Abendroth, Juliane Brock, Javier Serrania, Anke Becker, Ulla Bonas

Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)

Katarzyna J. Maresz, Annelie Hellvard, Aneta Sroka, Karina Adamowicz, Ewa Bielecka, Joanna Koziel, Katarzyna Gawron, Danuta Mizgalska, Katarzyna A. Marcinska, Malgorzata Benedyk, Krzysztof Pyrc, Anne-Marie Quirke, Roland Jonsson, Saba Alzabin, Patrick J. Venables, Ky-Anh Nguyen, Piotr Mydel, Jan Potempa

Modulation of Enhancer Looping and Differential Gene Targeting by Epstein-Barr Virus Transcription Factors Directs Cellular Reprogramming

Michael J. McClellan, C. David Wood, Opeoluwa Ojeniyi, Tim J. Cooper, Aditi Kanhere, Aaron Arvey, Helen M. Webb, Richard D. Palermo, Marie L. Harth-Hertle, Bettina Kempkes, Richard G. Jenner, Michelle J. West

Genome-Wide Mouse Mutagenesis Reveals CD45-Mediated T Cell Function as Critical in Protective Immunity to HSV-1

Grégory Caignard, Gabriel A. Leiva-Torres, Michael Leney-Greene, Benoit Charbonneau, Anne Dumaine, Nassima Fodil-Cornu, Michal Pyzik, Pablo Cingolani, Jeremy Schwartzentruber, Jeremy Dupaul-Chicoine, Huaijian Guo, Maya Saleh, André Veillette, Marc Lathrop, Mathieu Blanchette, Jacek Majewski, Angela Pearson, Silvia M. Vidal

A Comprehensive Analysis of In Vitro and In Vivo Genetic Fitness of Pseudomonas aeruginosa Using High-Throughput Sequencing of Transposon Libraries

David Skurnik, Damien Roux, Hugues Aschard, Vincent Cattoir, Deborah Yoder-Himes, Stephen Lory, Gerald B. Pier

Proteomic Screening of Human Targets of Viral microRNAs Reveals Functions Associated with Immune Evasion and Angiogenesis

Amelia M. Gallaher, Sudipto Das, Zhen Xiao, Thorkell Andresson, Philippe Kieffer-Kwon, Christine Happel, Joseph Ziegelbauer

The Zebrafish as a New Model for the In Vivo Study of Shigella flexneri Interaction with Phagocytes and Bacterial Autophagy

Serge Mostowy, Laurent Boucontet, Maria J. Mazon Moya, Andrea Sirianni, Pierre Boudinot, Michael Hollinshead, Pascale Cossart, Philippe Herbomel, Jean-Pierre Levraud, Emma Colucci-Guyon

Identification of Immune and Viral Correlates of Norovirus Protective Immunity through Comparative Study of Intra-Cluster Norovirus Strains

Shu Zhu, Doron Regev, Makiko Watanabe, Danielle Hickman, Nissin Moussatche, Desyree Murta Jesus, Shannon M. Kahan, Sawsan Napthine, Ian Brierley, Robert N. Hunter III, Divya Devabhaktuni, Melissa K. Jones, Stephanie M. Karst

Midcell Recruitment of the DNA Uptake and Virulence Nuclease, EndA, for Pneumococcal Transformation

Matthieu J. Bergé, Alain Kamgoué, Bernard Martin, Patrice Polard, Nathalie Campo, Jean-Pierre Claverys

Multicellular Bacteria Deploy the Type VI Secretion System to Preemptively Strike Neighboring Cells

Christopher J. Alteri, Stephanie D. Himpsl, Shannon R. Pickens, Jonathon R. Lindner, Jonathan S. Zora, Jessa E. Miller, Peter D. Arno, Samuel W. Straight, Harry L. T. Mobley

RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication

Andrei Nikonov, Tarmo Mölder, Rein Sikut, Kaja Kiiver, Andres Männik, Urve Toots, Aleksei Lulla, Valeria Lulla, Age Utt, Andres Merits, Mart Ustav

Vibrio cholerae Evades Neutrophil Extracellular Traps by the Activity of Two Extracellular Nucleases

Andrea Seper, Ava Hosseinzadeh, Gregor Gorkiewicz, Sabine Lichtenegger, Sandro Roier, Deborah R. Leitner, Marc Röhm, Andreas Grutsch, Joachim Reidl, Constantin F. Urban, Stefan Schild

Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish

Nuno Palha, Florence Guivel-Benhassine, Valérie Briolat, Georges Lutfalla, Marion Sourisseau, Felix Ellett, Chieh-Huei Wang, Graham J. Lieschke, Philippe Herbomel, Olivier Schwartz, Jean-Pierre Levraud

The JNK Pathway Is a Key Mediator of Anopheles gambiae Antiplasmodial Immunity

Lindsey S. Garver, Giselle de Almeida Oliveira, Carolina Barillas-Mury

The CLIP-Domain Serine Protease Homolog SPCLIP1 Regulates Complement Recruitment to Microbial Surfaces in the Malaria Mosquito Anopheles gambiae

Michael Povelones, Lavanya Bhagavatula, Hassan Yassine, Lee Aun Tan, Leanna M. Upton, Mike A. Osta, George K. Christophides