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Table of Contents: October 2006

COVER

Incomplete intestinal metaplasia

Image Credit: Light microscopy picture taken by C. Semino-Mora and A. Dubois using a Nikon Eclipse E800 Microscope and a QImaging MicroPublisher 5.0 RTV digital camera. Biopsy provided by V. Simko, Brooklyn VA Medical Center. Original magnification: 400x.
Issue Image

In the gastric mucosa of a patient with Helicobacter pylori infection and a precancerous lesion called "incomplete intestinal metaplasia" (Genta stain), the gastric cells lining a gland have been replaced by absorptive intestinal cells with visible brush border and goblet cells, which are normally present in the intestine, but not in the stomach. Goblet cells contain acidic mucins stained blue by Alcian blue. This type of precancerous transformation is caused by long-term infection with H. pylori, visible in the lumen of the gland as curved bacterial rods stained black by silver stain. A few bacteria invade the goblet cells and can be found within blood capillaries, where they bind to red blood cells (see Aspholm et al).

Opinion

Recent Common Ancestry of Ebola Zaire Virus Found in a Bat Reservoir

Roman Biek, Peter D Walsh, Eric M Leroy, Leslie A Real

Research Articles

Changes in the Expression of Human Cell Division Autoantigen-1 Influence Toxoplasma gondii Growth and Development

Jay R Radke, Robert G Donald, Amy Eibs, Maria E Jerome, Michael S Behnke, Paul Liberator, Michael W White

SabA Is the H. pylori Hemagglutinin and Is Polymorphic in Binding to Sialylated Glycans

Marina Aspholm, Farzad O Olfat, Jenny Nordén, Berit Sondén, Carina Lundberg, Rolf Sjöström, Siiri Altraja, Stefan Odenbreit, Rainer Haas, Torkel Wadström, Lars Engstrand, Cristina Semino-Mora, Hui Liu, André Dubois, Susann Teneberg, Anna Arnqvist, Thomas Borén

IAP-IAP Complexes Required for Apoptosis Resistance of C. trachomatis–Infected Cells

Krishnaraj Rajalingam, Manu Sharma, Nicole Paland, Robert Hurwitz, Oliver Thieck, Monique Oswald, Nikolaus Machuy, Thomas Rudel

EC5S Ubiquitin Complex Is Recruited by KSHV Latent Antigen LANA for Degradation of the VHL and p53 Tumor Suppressors

Qi-Liang Cai, Jason S Knight, Suhbash C Verma, Philip Zald, Erle S Robertson

RpoS Controls the Vibrio cholerae Mucosal Escape Response

Alex Toftgaard Nielsen, Nadia A Dolganov, Glen Otto, Michael C Miller, Cheng Yen Wu, Gary K Schoolnik

Anthrax Toxin Receptor 2–Dependent Lethal Toxin Killing In Vivo

Heather M Scobie, Darran J Wigelsworth, John M Marlett, Diane Thomas, G. Jonah A Rainey, D. Borden Lacy, Marianne Manchester, R. John Collier, John A. T Young

Isolation from Cattle of a Prion Strain Distinct from That Causing Bovine Spongiform Encephalopathy

Vincent Béringue, Anna Bencsik, Annick Le Dur, Fabienne Reine, Thanh Lan Laï, Nathalie Chenais, Gaëlle Tilly, Anne-Gaëlle Biacabé, Thierry Baron, Jean-Luc Vilotte, Hubert Laude

Phylogenetic Relationships of the Wolbachia of Nematodes and Arthropods

Katelyn Fenn, Claire Conlon, Martin Jones, Michael A Quail, Nancy E Holroyd, Julian Parkhill, Mark Blaxter

COPI Activity Coupled with Fatty Acid Biosynthesis Is Required for Viral Replication

Sara Cherry, Amit Kunte, Hui Wang, Carolyn Coyne, Robert B Rawson, Norbert Perrimon

Correction

Correction: The Tripartite Associations between Bacteriophage, Wolbachia, and Arthropods

Seth R Bordenstein, Michelle L Marshall, Adam J Fry, Ulandt Kim, Jennifer J Wernegreen