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Table of Contents: March 2007

COVER

HIV-infected macrophage

Image Credit: Photograph provided by Anja Habermann, Heidelberg University.
Issue Image

Electron micrograph of a thin section through an HIV-1-infected macrophage. The membrane-impermeant dye ruthenium red forms an electron-dense coat on the plasma membrane. Thus, it becomes obvious that virus particles, which are also stained with ruthenium red, accumulate in a deep invagination that is continuous with the plasma membrane (see Welsch et al).

Opinions

Novel Strategy to Prevent Otitis Media Caused by Colonizing Streptococcus pneumoniae

Jonathan A McCullers, Åsa Karlström, Amy R Iverson, Jutta M Loeffler, Vincent A Fischetti

H5N1 Viruses and Vaccines

Kanta Subbarao, Catherine Luke

Research Articles

Systematic Identification of Cellular Signals Reactivating Kaposi Sarcoma–Associated Herpesvirus

Fuqu Yu, Josephine N Harada, Helen J Brown, Hongyu Deng, Moon Jung Song, Ting-Ting Wu, Juran Kato-Stankiewicz, Christian G Nelson, Jeffrey Vieira, Fuyuhiko Tamanoi, Sumit K Chanda, Ren Sun

Adaptation to Human Populations Is Revealed by Within-Host Polymorphisms in HIV-1 and Hepatitis C Virus

Art F. Y Poon, Sergei L. Kosakovsky Pond, Phil Bennett, Douglas D Richman, Andrew J. Leigh Brown, Simon D. W Frost

Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV

Anneleen Hombrouck, Jan De Rijck, Jelle Hendrix, Linos Vandekerckhove, Arnout Voet, Marc De Maeyer, Myriam Witvrouw, Yves Engelborghs, Frauke Christ, Rik Gijsbers, Zeger Debyser

Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction

Darrell Desveaux, Alex U Singer, Ai-Jiuan Wu, Brian C McNulty, Laura Musselwhite, Zachary Nimchuk, John Sondek, Jeffery L Dangl

HIV-1 Buds Predominantly at the Plasma Membrane of Primary Human Macrophages

Sonja Welsch, Oliver T Keppler, Anja Habermann, Ina Allespach, Jacomine Krijnse-Locker, Hans-Georg Kräusslich

Drosophila eiger Mutants Are Sensitive to Extracellular Pathogens

David S Schneider, Janelle S Ayres, Stephanie M Brandt, Alexandre Costa, Marc S Dionne, Michael D Gordon, Eric M Mabery, Madeleine G Moule, Linh N Pham, Mimi M Shirasu-Hiza

Transport of Streptococcus pneumoniae Capsular Polysaccharide in MHC Class II Tubules

Tom Li Stephen, Mario Fabri, Laura Groneck, Till A Röhn, Helena Hafke, Nirmal Robinson, Jens Rietdorf, David Schrama, Jürgen C Becker, Georg Plum, Martin Krönke, Harald Kropshofer, Wiltrud M Kalka-Moll

Population Genomics of the Immune Evasion (var) Genes of Plasmodium falciparum

Alyssa E Barry, Aleksandra Leliwa-Sytek, Livingston Tavul, Heather Imrie, Florence Migot-Nabias, Stuart M Brown, Gilean A. V McVean, Karen P Day

Dynorphin Activates Quorum Sensing Quinolone Signaling in Pseudomonas aeruginosa

Olga Zaborina, Francois Lepine, Gaoping Xiao, Vesta Valuckaite, Yimei Chen, Terry Li, Mae Ciancio, Alex Zaborin, Elaine Petroff, Jerrold R Turner, Laurence G Rahme, Eugene Chang, John C Alverdy

Transcriptional Regulation by Protein Kinase A in Cryptococcus neoformans

Guanggan Hu, Barbara R Steen, Tianshun Lian, Anita P Sham, Nicola Tam, Kristin L Tangen, James W Kronstad

Essential Gene Identification and Drug Target Prioritization in Aspergillus fumigatus

Wenqi Hu, Susan Sillaots, Sebastien Lemieux, John Davison, Sarah Kauffman, Anouk Breton, Annie Linteau, Chunlin Xin, Joel Bowman, Jeff Becker, Bo Jiang, Terry Roemer

A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes

Linh N Pham, Marc S Dionne, Mimi Shirasu-Hiza, David S Schneider

Conversion of the BASE Prion Strain into the BSE Strain: The Origin of BSE?

Raffaella Capobianco, Cristina Casalone, Silvia Suardi, Michela Mangieri, Claudia Miccolo, Lucia Limido, Marcella Catania, Giacomina Rossi, Giuseppe Di Fede, Giorgio Giaccone, Maria Grazia Bruzzone, Ludovico Minati, Cristiano Corona, Pierluigi Acutis, Daniela Gelmetti, Guerino Lombardi, Martin H Groschup, Anne Buschmann, Gianluigi Zanusso, Salvatore Monaco, Maria Caramelli, Fabrizio Tagliavini

Outer Surface Protein B Is Critical for Borrelia burgdorferi Adherence and Survival within Ixodes Ticks

Girish Neelakanta, Xin Li, Utpal Pal, Xianzhong Liu, Deborah S Beck, Kathleen DePonte, Durland Fish, Fred S Kantor, Erol Fikrig

LRP5 and LRP6 Are Not Required for Protective Antigen–Mediated Internalization or Lethality of Anthrax Lethal Toxin

John J Young, Jennifer L Bromberg-White, Cassandra Zylstra, Joseph T Church, Elissa Boguslawski, James H Resau, Bart O Williams, Nicholas S Duesbery

TBK1 Protects Vacuolar Integrity during Intracellular Bacterial Infection

Andrea L Radtke, Laura M Delbridge, Siddharth Balachandran, Glen N Barber, Mary X. D O'Riordan

Female Inheritance of Malarial lap Genes Is Essential for Mosquito Transmission

J. Dale Raine, Andrea Ecker, Jacqui Mendoza, Rita Tewari, Rebecca R Stanway, Robert E Sinden

Correction

Correction: H-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria

Sacha Lucchini, Gary Rowley, Martin D Goldberg, Douglas Hurd, Marcus Harrison, Jay C. D Hinton