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Table of Contents: February 2008

COVER

Chikungunya virus antigens

Image Credit:
Issue Image

Fibroblasts of the endomysium of skeletal muscle are immunolabeled for Chikungunya virus antigens and appear in red. The basal lamina (collagen IV) appear in green and nuclei in blue (see Couderc et al., e29).

Image Credit: T. Couderc, F. Chrétien, and M. Lecuit, Institut Pasteur, Paris, France

Opinion

Review

Research Articles

Evolution of a TRIM5-CypA Splice Isoform in Old World Monkeys

Ruchi M. Newman, Laura Hall, Andrea Kirmaier, Lu-Ann Pozzi, Erez Pery, Michael Farzan, Shawn P. O'Neil, Welkin Johnson

IL-10 from CD4+CD25Foxp3CD127 Adaptive Regulatory T Cells Modulates Parasite Clearance and Pathology during Malaria Infection

Kevin N. Couper, Daniel G. Blount, Mark S. Wilson, Julius C. Hafalla, Yasmine Belkaid, Masahito Kamanaka, Richard A. Flavell, J. Brian de Souza, Eleanor M. Riley

Interleukin-6 Is Crucial for Recall of Influenza-Specific Memory CD4+ T Cells

Maria Paula Longhi, Kate Wright, Sarah N. Lauder, Mari A. Nowell, Gareth W. Jones, Andrew J. Godkin, Simon A. Jones, Awen M. Gallimore

The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22

Stephen D. Barr, James R. Smiley, Frederic D. Bushman

Adenylyl Cyclase α and cAMP Signaling Mediate Plasmodium Sporozoite Apical Regulated Exocytosis and Hepatocyte Infection

Takeshi Ono, Laura Cabrita-Santos, Ricardo Leitao, Esther Bettiol, Lisa A. Purcell, Olga Diaz-Pulido, Lucy B. Andrews, Takushi Tadakuma, Purnima Bhanot, Maria M. Mota, Ana Rodriguez

An RND-Type Efflux System in Borrelia burgdorferi Is Involved in Virulence and Resistance to Antimicrobial Compounds

Ignas Bunikis, Katrin Denker, Yngve Östberg, Christian Andersen, Roland Benz, Sven Bergström

Hepatocyte Permissiveness to Plasmodium Infection Is Conveyed by a Short and Structurally Conserved Region of the CD81 Large Extracellular Domain

Samir Yalaoui, Sergine Zougbédé, Stéphanie Charrin, Olivier Silvie, Cécile Arduise, Khemais Farhati, Claude Boucheix, Dominique Mazier, Eric Rubinstein, Patrick Froissard

Metagenomic Analysis of Human Diarrhea: Viral Detection and Discovery

Stacy R. Finkbeiner, Adam F. Allred, Phillip I. Tarr, Eileen J. Klein, Carl D. Kirkwood, David Wang

Multiple Reassortment Events in the Evolutionary History of H1N1 Influenza A Virus Since 1918

Martha I. Nelson, Cécile Viboud, Lone Simonsen, Ryan T. Bennett, Sara B. Griesemer, Kirsten St. George, Jill Taylor, David J. Spiro, Naomi A. Sengamalay, Elodie Ghedin, Jeffery K. Taubenberger, Edward C. Holmes

Activation of Invariant NKT Cells Exacerbates Experimental Visceral Leishmaniasis

Amanda C. Stanley, Yonghong Zhou, Fiona H. Amante, Louise M. Randall, Ashraful Haque, Daniel G. Pellicci, Geoff R. Hill, Mark J. Smyth, Dale I. Godfrey, Christian R. Engwerda

Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis

Zsolt Tallóczy, Jose Martinez, Danielle Joset, Yonaton Ray, Attila Gácser, Sima Toussi, Noboru Mizushima, Josh Nosanchuk, Harris Goldstein, John Loike, David Sulzer, Laura Santambrogio

A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease

Thérèse Couderc, Fabrice Chrétien, Clémentine Schilte, Olivier Disson, Madly Brigitte, Florence Guivel-Benhassine, Yasmina Touret, Georges Barau, Nadège Cayet, Isabelle Schuffenecker, Philippe Desprès, Fernando Arenzana-Seisdedos, Alain Michault, Matthew L Albert, Marc Lecuit

Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization

Joppe W. R Hovius, Marein A. W. P de Jong, Jeroen den Dunnen, Manja Litjens, Erol Fikrig, Tom van der Poll, Sonja I Gringhuis, Teunis B. H Geijtenbeek

Control of M. tuberculosis ESAT-6 Secretion and Specific T Cell Recognition by PhoP

Wafa Frigui, Daria Bottai, Laleh Majlessi, Marc Monot, Emmanuelle Josselin, Priscille Brodin, Thierry Garnier, Brigitte Gicquel, Carlos Martin, Claude Leclerc, Stewart T Cole, Roland Brosch

Mucosal Damage and Neutropenia Are Required for Candida albicans Dissemination

Andrew Y Koh, Julia R Köhler, Kathleen T Coggshall, Nico Van Rooijen, Gerald B Pier

Forward Genetic Analysis of the Apicomplexan Cell Division Cycle in Toxoplasma gondii

Marc-Jan Gubbels, Margaret Lehmann, Mani Muthalagi, Maria E Jerome, Carrie F Brooks, Tomasz Szatanek, Jayme Flynn, Ben Parrot, Josh Radke, Boris Striepen, Michael W White

Nucleotide Biosynthesis Is Critical for Growth of Bacteria in Human Blood

Shalaka Samant, Hyunwoo Lee, Mahmood Ghassemi, Juan Chen, James L Cook, Alexander S Mankin, Alexander A Neyfakh

Human Innate Mycobacterium tuberculosis–Reactive αβTCR+ Thymocytes

Marielle C Gold, Heather D Ehlinger, Matthew S Cook, Susan K Smyk-Pearson, Paul T Wille, Ross M Ungerleider, Deborah A Lewinsohn, David M Lewinsohn

Nanobacteria Are Mineralo Fetuin Complexes

Didier Raoult, Michel Drancourt, Saïd Azza, Claude Nappez, Régis Guieu, Jean-Marc Rolain, Patrick Fourquet, Bernard Campagna, Bernard La Scola, Jean-Louis Mege, Pascal Mansuelle, Eric Lechevalier, Yvon Berland, Jean-Pierre Gorvel, Patricia Renesto

Structural Insight into Epitopes in the Pregnancy-Associated Malaria Protein VAR2CSA

Pernille Andersen, Morten A Nielsen, Mafalda Resende, Thomas S Rask, Madeleine Dahlbäck, Thor Theander, Ole Lund, Ali Salanti

Structure–Function Aspects of PstS in Multi-Drug–Resistant Pseudomonas aeruginosa

Olga Zaborina, Christopher Holbrook, Yimei Chen, Jason Long, Alexander Zaborin, Irina Morozova, Hoylan Fernandez, Yingmin Wang, Jerrold R Turner, John C Alverdy

Iron Source Preference and Regulation of Iron Uptake in Cryptococcus neoformans

Won Hee Jung, Anita Sham, Tianshun Lian, Arvinder Singh, Daniel J Kosman, James W Kronstad

The Mannose Receptor Mediates Dengue Virus Infection of Macrophages

Joanna L Miller, Barend J. M deWet, Luisa Martinez-Pomares, Catherine M Radcliffe, Raymond A Dwek, Pauline M Rudd, Siamon Gordon

Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1

Suzana P Salcedo, María Ines Marchesini, Hugues Lelouard, Emilie Fugier, Gilles Jolly, Stephanie Balor, Alexandre Muller, Nicolas Lapaque, Olivier Demaria, Lena Alexopoulou, Diego J Comerci, Rodolfo A Ugalde, Philippe Pierre, Jean-Pierre Gorvel

Inhibition of IκB Kinase by Vaccinia Virus Virulence Factor B14

Ron A.-J Chen, Grigory Ryzhakov, Samantha Cooray, Felix Randow, Geoffrey L Smith

A Francisella Mutant in Lipid A Carbohydrate Modification Elicits Protective Immunity

Duangjit Kanistanon, Adeline M Hajjar, Mark R Pelletier, Larry A Gallagher, Thomas Kalhorn, Scott A Shaffer, David R Goodlett, Laurence Rohmer, Mitchell J Brittnacher, Shawn J Skerrett, Robert K Ernst

NetB, a New Toxin That Is Associated with Avian Necrotic Enteritis Caused by Clostridium perfringens

Anthony L Keyburn, John D Boyce, Paola Vaz, Trudi L Bannam, Mark E Ford, Dane Parker, Antonio Di Rubbo, Julian I Rood, Robert J Moore

Tonsilar NK Cells Restrict B Cell Transformation by the Epstein-Barr Virus via IFN-γ

Till Strowig, Fabienne Brilot, Frida Arrey, Gwenola Bougras, Dolca Thomas, William A Muller, Christian Münz

TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle

Pradeep D Uchil, Brian D Quinlan, Wai-Tsing Chan, Joseph M Luna, Walther Mothes

The Effect of Trim5 Polymorphisms on the Clinical Course of HIV-1 Infection

Daniëlle van Manen, Maarten A. N Rits, Corrine Beugeling, Karel van Dort, Hanneke Schuitemaker, Neeltje A Kootstra

Plasmodium falciparum Regulatory Subunit of cAMP-Dependent PKA and Anion Channel Conductance

Anaïs Merckx, Marie-Paule Nivez, Guillaume Bouyer, Pietro Alano, Gordon Langsley, Kirk Deitsch, Serge Thomas, Christian Doerig, Stéphane Egée

The Macaque Gut Microbiome in Health, Lentiviral Infection, and Chronic Enterocolitis

Philip McKenna, Christian Hoffmann, Nana Minkah, Pyone Pyone Aye, Andrew Lackner, Zongzhi Liu, Catherine A Lozupone, Micah Hamady, Rob Knight, Frederic D Bushman

Persistent Coxiella burnetii Infection in Mice Overexpressing IL-10: An Efficient Model for Chronic Q Fever Pathogenesis

Soraya Meghari, Yassina Bechah, Christian Capo, Hubert Lepidi, Didier Raoult, Peter J Murray, Jean-Louis Mege

Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68

Bonsu Ku, Jae-Sung Woo, Chengyu Liang, Kwang-Hoon Lee, Hyang-Suk Hong, Xiaofei E, Key-Sun Kim, Jae U Jung, Byung-Ha Oh