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Table of Contents: August 2008

COVER

Image Credit: Photograph courtesy of Pierre Poilecot, CIRAD.
Issue Image
White-faced Whistling Duck Dendrocygna viduata fitted with an 18g solar powered satellite transmitter.

Movements of one naturally infected duck were monitored in Nigeria by satellite telemetry (or using a satellite tracking system), providing rare evidence of a non-lethal natural infection by an avian influenza virus with a highly pathogenic viral genotype in wild birds (see Gaidet et al., doi:10.1371/journal.ppat.1000127).

Opinion

Research Articles

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

Franck Tarendeau, Thibaut Crepin, Delphine Guilligay, Rob W. H. Ruigrok, Stephen Cusack, Darren J. Hart

A C-Terminal Protease-Resistant Prion Fragment Distinguishes Ovine “CH1641-Like” Scrapie from Bovine Classical and L-Type BSE in Ovine Transgenic Mice

Thierry Baron, Anna Bencsik, Johann Vulin, Anne-Gaëlle Biacabe, Eric Morignat, Jérémy Verchere, Dominique Betemps

Superior Immunogenicity of Inactivated Whole Virus H5N1 Influenza Vaccine is Primarily Controlled by Toll-like Receptor Signalling

Felix Geeraedts, Nadege Goutagny, Veit Hornung, Martina Severa, Aalzen de Haan, Judith Pool, Jan Wilschut, Katherine A. Fitzgerald, Anke Huckriede

Accelerated High Fidelity Prion Amplification Within and Across Prion Species Barriers

Kristi M. Green, Joaquín Castilla, Tanya S. Seward, Dana L. Napier, Jean E. Jewell, Claudio Soto, Glenn C. Telling

Yersinia enterocolitica Serum Resistance Proteins YadA and Ail Bind the Complement Regulator C4b-Binding Protein

Vesa Kirjavainen, Hanna Jarva, Marta Biedzka-Sarek, Anna M. Blom, Mikael Skurnik, Seppo Meri

Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus

Mohammad F. Saeed, Andrey A. Kolokoltsov, Alexander N. Freiberg, Michael R. Holbrook, Robert A. Davey

XIAP Regulates Cytosol-Specific Innate Immunity to Listeria Infection

Laura D. Bauler, Colin S. Duckett, Mary X. D. O'Riordan

Evolutionary and Transmission Dynamics of Reassortant H5N1 Influenza Virus in Indonesia

Tommy Tsan-Yuk Lam, Chung-Chau Hon, Oliver G. Pybus, Sergei L. Kosakovsky Pond, Raymond Tze-Yeung Wong, Chi-Wai Yip, Fanya Zeng, Frederick Chi-Ching Leung

HIV-1 Nef Targets MHC-I and CD4 for Degradation Via a Final Common β-COP–Dependent Pathway in T Cells

Malinda R. Schaefer, Elizabeth R. Wonderlich, Jeremiah F. Roeth, Jolie A. Leonard, Kathleen L. Collins

Molecular Epidemiology of A/H3N2 and A/H1N1 Influenza Virus during a Single Epidemic Season in the United States

Martha I. Nelson, Laurel Edelman, David J. Spiro, Alex R. Boyne, Jayati Bera, Rebecca Halpin, Elodie Ghedin, Mark A. Miller, Lone Simonsen, Cecile Viboud, Edward C. Holmes

Viral Paratransgenesis in the Malaria Vector Anopheles gambiae

Xiaoxia Ren, Egbert Hoiczyk, Jason L. Rasgon

Diversification of Rice Yellow Mottle Virus and Related Viruses Spans the History of Agriculture from the Neolithic to the Present

Denis Fargette, Agnès Pinel-Galzi, Drissa Sérémé, Séverine Lacombe, Eugénie Hébrard, Oumar Traoré, Gnissa Konaté

Vesicular Egress of Non-Enveloped Lytic Parvoviruses Depends on Gelsolin Functioning

Séverine Bär, Laurent Daeffler, Jean Rommelaere, Jürg P. F. Nüesch

Evidence of Infection by H5N2 Highly Pathogenic Avian Influenza Viruses in Healthy Wild Waterfowl

Nicolas Gaidet, Giovanni Cattoli, Saliha Hammoumi, Scott H. Newman, Ward Hagemeijer, John Y. Takekawa, Julien Cappelle, Tim Dodman, Tony Joannis, Patricia Gil, Isabella Monne, Alice Fusaro, Ilaria Capua, Shiiwuua Manu, Pierfrancesco Micheloni, Ulf Ottosson, John H. Mshelbwala, Juan Lubroth, Joseph Domenech, François Monicat

Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis

Stephen C. Graham, Mohammad W. Bahar, Samantha Cooray, Ron A.-J. Chen, Daniel M. Whalen, Nicola G. A. Abrescia, David Alderton, Raymond J. Owens, David I. Stuart, Geoffrey L. Smith, Jonathan M. Grimes

An Erythrocyte Vesicle Protein Exported by the Malaria Parasite Promotes Tubovesicular Lipid Import from the Host Cell Surface

Pamela A. Tamez, Souvik Bhattacharjee, Christiaan van Ooij, N. Luisa Hiller, Manuel Llinás, Bharath Balu, John H. Adams, Kasturi Haldar

Structure of the Head of the Bartonella Adhesin BadA

Pawel Szczesny, Dirk Linke, Astrid Ursinus, Kerstin Bär, Heinz Schwarz, Tanja M. Riess, Volkhard A. J. Kempf, Andrei N. Lupas, Jörg Martin, Kornelius Zeth

Rudra Interrupts Receptor Signaling Complexes to Negatively Regulate the IMD Pathway

Kamna Aggarwal, Florentina Rus, Christie Vriesema-Magnuson, Deniz Ertürk-Hasdemir, Nicholas Paquette, Neal Silverman

Temperature Shift and Host Cell Contact Up-Regulate Sporozoite Expression of Plasmodium falciparum Genes Involved in Hepatocyte Infection

Anthony Siau, Olivier Silvie, Jean-François Franetich, Samir Yalaoui, Carine Marinach, Laurent Hannoun, Geert-Jaan van Gemert, Adrian J. F. Luty, Emmanuel Bischoff, Peter H. David, Georges Snounou, Catherine Vaquero, Patrick Froissard, Dominique Mazier

The Role of B-cells and IgM Antibodies in Parasitemia, Anemia, and VSG Switching in Trypanosoma brucei–Infected Mice

Stefan Magez, Anita Schwegmann, Robert Atkinson, Filip Claes, Michael Drennan, Patrick De Baetselier, Frank Brombacher

Human Cytomegalovirus UL18 Utilizes US6 for Evading the NK and T-Cell Responses

Youngkyun Kim, Boyoun Park, Sunglim Cho, Jinwook Shin, Kwangmin Cho, Youngsoo Jun, Kwangseog Ahn

Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation

Caitlin O'Mahony, Paul Scully, David O'Mahony, Sharon Murphy, Frances O'Brien, Anne Lyons, Graham Sherlock, John MacSharry, Barry Kiely, Fergus Shanahan, Liam O'Mahony

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

Lucy A. Perrone, Julie K. Plowden, Adolfo García-Sastre, Jacqueline M. Katz, Terrence M. Tumpey

Histidine-Rich Glycoprotein Protects from Systemic Candida Infection

Victoria Rydengård, Oonagh Shannon, Katarina Lundqvist, Lukasz Kacprzyk, Anna Chalupka, Anna-Karin Olsson, Matthias Mörgelin, Willi Jahnen-Dechent, Martin Malmsten, Artur Schmidtchen

Legionella Eukaryotic-Like Type IV Substrates Interfere with Organelle Trafficking

Karim Suwwan de Felipe, Robert T. Glover, Xavier Charpentier, O. Roger Anderson, Moraima Reyes, Christopher D. Pericone, Howard A. Shuman