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Table of Contents: November 2008

COVER

Color-enhanced electron micrograph of Ebola virus particles.

Image Credit: Thomas W. Geisbert, Boston University School of Medicine
Issue Image

Ebola virus causes severe hemorrhagic fever in humans and nonhuman primates, with case fatality rates often exceeding 80% (see Geisbert et al., doi:10.1371/journal.ppat.1000225).

Review

Research Articles

Stage-Specific Sampling by Pattern Recognition Receptors during Candida albicans Phagocytosis

Sigrid E. M. Heinsbroek, Philip R. Taylor, Fernando O. Martinez, Luisa Martinez-Pomares, Gordon D. Brown, Siamon Gordon

Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila

Sunny Shin, Christopher L. Case, Kristina A. Archer, Catarina V. Nogueira, Koichi S. Kobayashi, Richard A. Flavell, Craig R. Roy, Dario S. Zamboni

Migratory Dermal Dendritic Cells Act as Rapid Sensors of Protozoan Parasites

Lai Guan Ng, Alice Hsu, Michael A. Mandell, Ben Roediger, Christoph Hoeller, Paulus Mrass, Amaya Iparraguirre, Lois L. Cavanagh, James A. Triccas, Stephen M. Beverley, Phillip Scott, Wolfgang Weninger

Vesicular Stomatitis Virus-Based Ebola Vaccine Is Well-Tolerated and Protects Immunocompromised Nonhuman Primates

Thomas W. Geisbert, Kathleen M. Daddario-DiCaprio, Mark G. Lewis, Joan B. Geisbert, Allen Grolla, Anders Leung, Jason Paragas, Lennox Matthias, Mark A. Smith, Steven M. Jones, Lisa E. Hensley, Heinz Feldmann, Peter B. Jahrling

A Structural Model of the Staphylococcus aureus ClfA–Fibrinogen Interaction Opens New Avenues for the Design of Anti-Staphylococcal Therapeutics

Vannakambadi K. Ganesh, Jose J. Rivera, Emanuel Smeds, Ya-Ping Ko, M. Gabriela Bowden, Elisabeth R. Wann, Shivasankarappa Gurusiddappa, J. Ross Fitzgerald, Magnus Höök

GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors

Atsuko Fukazawa, Carmen Alonso, Kiyotaka Kurachi, Sonal Gupta, Cammie F. Lesser, Beth Ann McCormick, Hans-Christian Reinecker

Role of Amphipathic Helix of a Herpesviral Protein in Membrane Deformation and T Cell Receptor Downregulation

Chan-Ki Min, Sun-Young Bang, Bon-A Cho, Yun-Hui Choi, Jae-Seong Yang, Sun-Hwa Lee, Seung-Yong Seong, Ki Woo Kim, Sanguk Kim, Jae Ung Jung, Myung-Sik Choi, Ik-Sang Kim, Nam-Hyuk Cho

The Bicarbonate Transporter Is Essential for Bacillus anthracis Lethality

Adam C. Wilson, Magali Soyer, James A. Hoch, Marta Perego

Interrelationship between Dendritic Cell Trafficking and Francisella tularensis Dissemination following Airway Infection

Erez Bar-Haim, Orit Gat, Gal Markel, Hila Cohen, Avigdor Shafferman, Baruch Velan

Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda

Jonathan S. Towner, Tara K. Sealy, Marina L. Khristova, César G. Albariño, Sean Conlan, Serena A. Reeder, Phenix-Lan Quan, W. Ian Lipkin, Robert Downing, Jordan W. Tappero, Samuel Okware, Julius Lutwama, Barnabas Bakamutumaho, John Kayiwa, James A. Comer, Pierre E. Rollin, Thomas G. Ksiazek, Stuart T. Nichol

A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal Antifolates

Karthikeyan Ganesan, Napawan Ponmee, Lei Jiang, Joseph W. Fowble, John White, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong, Prapon Wilairat, Pradipsinh K. Rathod

A Critical Role of a Cellular Membrane Traffic Protein in Poliovirus RNA Replication

George A. Belov, Qian Feng, Krisztina Nikovics, Catherine L. Jackson, Ellie Ehrenfeld

The Hyphal-Associated Adhesin and Invasin Als3 of Candida albicans Mediates Iron Acquisition from Host Ferritin

Ricardo S. Almeida, Sascha Brunke, Antje Albrecht, Sascha Thewes, Michael Laue, John E. Edwards Jr, Scott G. Filler, Bernhard Hube

Rac1 Is Required for Pathogenicity and Chm1-Dependent Conidiogenesis in Rice Fungal Pathogen Magnaporthe grisea

Jisheng Chen, Wu Zheng, Shiqin Zheng, Dongmei Zhang, Weijian Sang, Xiao Chen, Guangpu Li, Guodong Lu, Zonghua Wang

Cryoelectron Tomography of HIV-1 Envelope Spikes: Further Evidence for Tripod-Like Legs

Ping Zhu, Hanspeter Winkler, Elena Chertova, Kenneth A. Taylor, Kenneth H. Roux

Alteration of Blood–Brain Barrier Integrity by Retroviral Infection

Philippe V. Afonso, Simona Ozden, Marie-Christine Cumont, Danielle Seilhean, Luis Cartier, Payam Rezaie, Sarah Mason, Sophie Lambert, Michel Huerre, Antoine Gessain, Pierre-Olivier Couraud, Claudine Pique, Pierre-Emmanuel Ceccaldi, Ignacio A. Romero

Resistance of Bovine Spongiform Encephalopathy (BSE) Prions to Inactivation

Kurt Giles, David V. Glidden, Robyn Beckwith, Rose Seoanes, David Peretz, Stephen J. DeArmond, Stanley B. Prusiner

Key Role of Splenic Myeloid DCs in the IFN-αβ Response to Adenoviruses In Vivo

György Fejer, Lisa Drechsel, Jan Liese, Ulrike Schleicher, Zsolt Ruzsics, Nicola Imelli, Urs F. Greber, Simone Keck, Bernd Hildenbrand, Anne Krug, Christian Bogdan, Marina A. Freudenberg

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

Pascale Peyron, Julien Vaubourgeix, Yannick Poquet, Florence Levillain, Catherine Botanch, Fabienne Bardou, Mamadou Daffé, Jean-François Emile, Bruno Marchou, Pere-Joan Cardona, Chantal de Chastellier, Frédéric Altare

Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression

Eva-K. Pauli, Mirco Schmolke, Thorsten Wolff, Dorothee Viemann, Johannes Roth, Johannes G. Bode, Stephan Ludwig

Broadening of Neutralization Activity to Directly Block a Dominant Antibody-Driven SARS-Coronavirus Evolution Pathway

Jianhua Sui, Daniel R. Aird, Azaibi Tamin, Akikazu Murakami, Meiying Yan, Anuradha Yammanuru, Huaiqi Jing, Biao Kan, Xin Liu, Quan Zhu, Qing-an Yuan, Gregory P. Adams, William J. Bellini, Jianguo Xu, Larry J. Anderson, Wayne A. Marasco

Urea-Mediated Cross-Presentation of Soluble Epstein-Barr Virus BZLF1 Protein

Sascha Barabas, Regina Gary, Tanja Bauer, Juha Lindner, Petra Lindner, Birgit Weinberger, Wolfgang Jilg, Hans Wolf, Ludwig Deml

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

Sven D. Willger, Srisombat Puttikamonkul, Kwang-Hyung Kim, James B. Burritt, Nora Grahl, Laurel J. Metzler, Robert Barbuch, Martin Bard, Christopher B. Lawrence, Robert A. Cramer Jr.

Kinome-Wide RNAi Screen Implicates at Least 5 Host Hepatocyte Kinases in Plasmodium Sporozoite Infection

Miguel Prudêncio, Cristina D. Rodrigues, Michael Hannus, Cécilie Martin, Eliana Real, Lígia A. Gonçalves, Céline Carret, Robert Dorkin, Ingo Röhl, Kerstin Jahn-Hoffmann, Adrian J. F. Luty, Robert Sauerwein, Christophe J. Echeverri, Maria M. Mota