Table of Contents: October 2009


An intimate relationship.

Image Credit: Volker Brinkmann, Max Planck Institute for Infection Biology
Issue Image

Chlamydia trachomatis is the leading cause of the preventable blindness trachoma worldwide and a major cause of sexually transmitted disease in developed countries. Hidden within the confines of an intracellular niche (shown), the bacterium wields its armament of defense, evasion, and procurement strategies. Rejman Lipinski et al. reveal another snippet of the Chlamydia–host cross-talk, demonstrating that distinct host Rab proteins are essential for the stability of the Golgi apparatus, a key host organelle intimately linked with infection outcome. Such insights will hopefully further broaden the options for the development of novel anti-chlamydial treatments (see Rejman Lipinski et al., doi:10.1371/journal.ppat.1000615).


Systematic Genetic Nomenclature for Type VII Secretion Systems

Wilbert Bitter, Edith N. G. Houben, Daria Bottai, Priscille Brodin, Eric J. Brown, Jeffery S. Cox, Keith Derbyshire, Sarah M. Fortune, Lian-Yong Gao, Jun Liu, Nicolaas C. Gey van Pittius, Alexander S. Pym, Eric J. Rubin, David R. Sherman, Stewart T. Cole, Roland Brosch



Helicobacter pylori's Unconventional Role in Health and Disease

Marion S. Dorer, Sarah Talarico, Nina R. Salama

The Application of Genomics to Emerging Zoonotic Viral Diseases

Bart L. Haagmans, Arno C. Andeweg, Albert D. M. E. Osterhaus

The Past and Future of Tuberculosis Research

Iñaki Comas, Sebastien Gagneux

Research Articles

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

Constantin F. Urban, David Ermert, Monika Schmid, Ulrike Abu-Abed, Christian Goosmann, Wolfgang Nacken, Volker Brinkmann, Peter R. Jungblut, Arturo Zychlinsky

Small Molecule Control of Virulence Gene Expression in Francisella tularensis

James C. Charity, LeeAnn T. Blalock, Michelle M. Costante-Hamm, Dennis L. Kasper, Simon L. Dove

A Neutralizing Human Monoclonal Antibody Protects against Lethal Disease in a New Ferret Model of Acute Nipah Virus Infection

Katharine N. Bossart, Zhongyu Zhu, Deborah Middleton, Jessica Klippel, Gary Crameri, John Bingham, Jennifer A. McEachern, Diane Green, Timothy J. Hancock, Yee-Peng Chan, Andrew C. Hickey, Dimiter S. Dimitrov, Lin-Fa Wang, Christopher C. Broder

Mycobacteria Exploit Host Hyaluronan for Efficient Extracellular Replication

Yukio Hirayama, Mamiko Yoshimura, Yuriko Ozeki, Isamu Sugawara, Tadashi Udagawa, Satoru Mizuno, Naoki Itano, Koji Kimata, Aki Tamaru, Hisashi Ogura, Kazuo Kobayashi, Sohkichi Matsumoto

Comparative Transcriptional and Genomic Analysis of Plasmodium falciparum Field Isolates

Margaret J. Mackinnon, Jinguang Li, Sachel Mok, Moses M. Kortok, Kevin Marsh, Peter R. Preiser, Zbynek Bozdech

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

Thierry Christophe, Mary Jackson, Hee Kyoung Jeon, Denis Fenistein, Monica Contreras-Dominguez, Jaeseung Kim, Auguste Genovesio, Jean-Philippe Carralot, Fanny Ewann, Eun Hye Kim, Sae Yeon Lee, Sunhee Kang, Min Jung Seo, Eun Jung Park, Henrieta Škovierová, Ha Pham, Giovanna Riccardi, Ji Youn Nam, Laurent Marsollier, Marie Kempf, Marie-Laure Joly-Guillou, Taegwon Oh, Won Kyung Shin, Zaesung No, Ulf Nehrbass, Roland Brosch, Stewart T. Cole, Priscille Brodin

Autocrine Production of β-Chemokines Protects CMV-Specific CD4+ T Cells from HIV Infection

Joseph P. Casazza, Jason M. Brenchley, Brenna J. Hill, Ribka Ayana, David Ambrozak, Mario Roederer, Daniel C. Douek, Michael R. Betts, Richard A. Koup

Bacterial Porin Disrupts Mitochondrial Membrane Potential and Sensitizes Host Cells to Apoptosis

Vera Kozjak-Pavlovic, Elke A. Dian-Lothrop, Michael Meinecke, Oliver Kepp, Katharina Ross, Krishnaraj Rajalingam, Anke Harsman, Eva Hauf, Volker Brinkmann, Dirk Günther, Ines Herrmann, Robert Hurwitz, Joachim Rassow, Richard Wagner, Thomas Rudel

Wolbachia Interferes with Ferritin Expression and Iron Metabolism in Insects

Natacha Kremer, Denis Voronin, Delphine Charif, Patrick Mavingui, Bertrand Mollereau, Fabrice Vavre

A Distinct Peripheral Blood Monocyte Phenotype Is Associated with Parasite Inhibitory Activity in Acute Uncomplicated Plasmodium falciparum Malaria

Pattamawan Chimma, Christian Roussilhon, Panudda Sratongno, Ronnatrai Ruangveerayuth, Kovit Pattanapanyasat, Jean-Louis Pérignon, David J. Roberts, Pierre Druilhe

Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation

Marcelo M. Samsa, Juan A. Mondotte, Nestor G. Iglesias, Iranaia Assunção-Miranda, Giselle Barbosa-Lima, Andrea T. Da Poian, Patricia T. Bozza, Andrea V. Gamarnik

Evolutionary Dynamics of Human Rotaviruses: Balancing Reassortment with Preferred Genome Constellations

Sarah M. McDonald, Jelle Matthijnssens, John K. McAllen, Erin Hine, Larry Overton, Shiliang Wang, Philippe Lemey, Mark Zeller, Marc Van Ranst, David J. Spiro, John T. Patton

Co-Regulation of NF-κB and Inflammasome-Mediated Inflammatory Responses by Myxoma Virus Pyrin Domain-Containing Protein M013

Masmudur M. Rahman, Mohamed R. Mohamed, Manbok Kim, Sherin Smallwood, Grant McFadden

The Nuclear Protein Sge1 of Fusarium oxysporum Is Required for Parasitic Growth

Caroline B. Michielse, Ringo van Wijk, Linda Reijnen, Erik M. M. Manders, Sonja Boas, Chantal Olivain, Claude Alabouvette, Martijn Rep

Coxsackievirus B3 Inhibits Antigen Presentation In Vivo, Exerting a Profound and Selective Effect on the MHC Class I Pathway

Christopher C. Kemball, Stephanie Harkins, Jason K. Whitmire, Claudia T. Flynn, Ralph Feuer, J. Lindsay Whitton

Induction of Membrane Ceramides: A Novel Strategy to Interfere with T Lymphocyte Cytoskeletal Reorganisation in Viral Immunosuppression

Evelyn Gassert, Elita Avota, Harry Harms, Georg Krohne, Erich Gulbins, Sibylle Schneider-Schaulies

EBNA1-Mediated Recruitment of a Histone H2B Deubiquitylating Complex to the Epstein-Barr Virus Latent Origin of DNA Replication

Feroz Sarkari, Teresa Sanchez-Alcaraz, Shan Wang, Melissa N. Holowaty, Yi Sheng, Lori Frappier

Variation of Neisseria gonorrhoeae Lipooligosaccharide Directs Dendritic Cell–Induced T Helper Responses

Sandra J. van Vliet, Liana Steeghs, Sven C. M. Bruijns, Medi M. Vaezirad, Christian Snijders Blok, Jésus A. Arenas Busto, Marcel Deken, Jos P. M. van Putten, Yvette van Kooyk

Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria

Carsten Schwan, Bärbel Stecher, Tina Tzivelekidis, Marco van Ham, Manfred Rohde, Wolf-Dietrich Hardt, Jürgen Wehland, Klaus Aktories

Probing the HIV-1 Genomic RNA Trafficking Pathway and Dimerization by Genetic Recombination and Single Virion Analyses

Michael D. Moore, Olga A. Nikolaitchik, Jianbo Chen, Marie-Louise Hammarskjöld, David Rekosh, Wei-Shau Hu

Viral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection of γHerpesvirus 68

Xiaofei E, Seungmin Hwang, Soohwan Oh, Jong-Soo Lee, Joseph H. Jeong, Yousang Gwack, Timothy F. Kowalik, Ren Sun, Jae U. Jung, Chengyu Liang

IL-10 Signaling Blockade Controls Murine West Nile Virus Infection

Fengwei Bai, Terrence Town, Feng Qian, Penghua Wang, Masahito Kamanaka, Tarah M. Connolly, David Gate, Ruth R. Montgomery, Richard A. Flavell, Erol Fikrig

A Granulin-Like Growth Factor Secreted by the Carcinogenic Liver Fluke, Opisthorchis viverrini, Promotes Proliferation of Host Cells

Michael J. Smout, Thewarach Laha, Jason Mulvenna, Banchob Sripa, Sutas Suttiprapa, Alun Jones, Paul J. Brindley, Alex Loukas

Transcriptional Regulation of Carbohydrate Metabolism in the Human Pathogen Candida albicans

Christopher Askew, Adnane Sellam, Elias Epp, Hervé Hogues, Alaka Mullick, André Nantel, Malcolm Whiteway

A Mouse Model for Studying Viscerotropic Disease Caused by Yellow Fever Virus Infection

Kathryn C. Meier, Christina L. Gardner, Mikhail V. Khoretonenko, William B. Klimstra, Kate D. Ryman

Rab6 and Rab11 Regulate Chlamydia trachomatis Development and Golgin-84-Dependent Golgi Fragmentation

Anette Rejman Lipinski, Julia Heymann, Charlotte Meissner, Alexander Karlas, Volker Brinkmann, Thomas F. Meyer, Dagmar Heuer

KSHV Manipulates Notch Signaling by DLL4 and JAG1 to Alter Cell Cycle Genes in Lymphatic Endothelia

Victoria Emuss, Dimitrios Lagos, Arnold Pizzey, Fiona Gratrix, Stephen R. Henderson, Chris Boshoff

MUC1 Limits Helicobacter pylori Infection both by Steric Hindrance and by Acting as a Releasable Decoy

Sara K. Lindén, Yong H. Sheng, Alison L. Every, Kim M. Miles, Emma C. Skoog, Timothy H. J. Florin, Philip Sutton, Michael A. McGuckin

Equine Rhinitis A Virus and Its Low pH Empty Particle: Clues Towards an Aphthovirus Entry Mechanism?

Tobias J. Tuthill, Karl Harlos, Thomas S. Walter, Nick J. Knowles, Elisabetta Groppelli, David J. Rowlands, David I. Stuart, Elizabeth E. Fry

Genes Selectively Up-Regulated by Pheromone in White Cells Are Involved in Biofilm Formation in Candida albicans

Nidhi Sahni, Song Yi, Karla J. Daniels, Thyagarajan Srikantha, Claude Pujol, David R. Soll

RNase L Mediated Protection from Virus Induced Demyelination

Derek D. C. Ireland, Stephen A. Stohlman, David R. Hinton, Parul Kapil, Robert H. Silverman, Roscoe A. Atkinson, Cornelia C. Bergmann

Helicobacter pylori Counteracts the Apoptotic Action of Its VacA Toxin by Injecting the CagA Protein into Gastric Epithelial Cells

Amanda Oldani, Mireille Cormont, Veronique Hofman, Valentina Chiozzi, Olivier Oregioni, Alexandra Canonici, Anna Sciullo, Patrizia Sommi, Alessia Fabbri, Vittorio Ricci, Patrice Boquet

Lethal Influenza Virus Infection in Macaques Is Associated with Early Dysregulation of Inflammatory Related Genes

Cristian Cillóniz, Kyoko Shinya, Xinxia Peng, Marcus J. Korth, Sean C. Proll, Lauri D. Aicher, Victoria S. Carter, Jean H. Chang, Darwyn Kobasa, Friedericke Feldmann, James E. Strong, Heinz Feldmann, Yoshihiro Kawaoka, Michael G. Katze

Non-Human Primate Model of Kaposi's Sarcoma-Associated Herpesvirus Infection

Heesoon Chang, Lynn M. Wachtman, Christine B. Pearson, Jong-Soo Lee, Hye-Ra Lee, Steven H. Lee, Jeffrey Vieira, Keith G. Mansfield, Jae U. Jung

Interactome Analyses Identify Ties of PrPC and Its Mammalian Paralogs to Oligomannosidic N-Glycans and Endoplasmic Reticulum-Derived Chaperones

Joel C. Watts, Hairu Huo, Yu Bai, Sepehr Ehsani, Amy Hye Won, Tujin Shi, Nathalie Daude, Agnes Lau, Rebecca Young, Lei Xu, George A. Carlson, David Williams, David Westaway, Gerold Schmitt-Ulms

HIV-1 Vpr Triggers Natural Killer Cell–Mediated Lysis of Infected Cells through Activation of the ATR-Mediated DNA Damage Response

Jeffrey Ward, Zachary Davis, Jason DeHart, Erik Zimmerman, Alberto Bosque, Enrico Brunetta, Domenico Mavilio, Vicente Planelles, Edward Barker