Advertisement

Table of Contents: January 2010

COVER

Listeria monocytogenes infection of the human placenta.

Image Credit: Jennifer R. Robbins and Anna I. Bakardjiev, University of California, San Francisco
Issue Image

L. monocytogenes causes abortions and preterm labor. Robbins et al. (see doi:10.1371/journal.ppat.1000732) used first trimester human placental organ cultures to quantitatively analyze how L. monocytogenes breaches the maternal-fetal barrier. The syncytiotrophoblast (red), which constitutes most of the placental surface and is bathed in maternal blood in vivo, is highly resistant to L. monocytogenes infection. Instead, extravillous cytotrophoblasts, which anchor the placenta in the uterus, serve as the primary portal of entry for L. monocytogenes (green). Nuclei are blue.

Opinions

Pearls

The Deadly Chytrid Fungus: A Story of an Emerging Pathogen

Erica Bree Rosenblum, Jamie Voyles, Thomas J. Poorten, Jason E. Stajich

Research Articles

Social Motility in African Trypanosomes

Michael Oberholzer, Miguel A. Lopez, Bryce T. McLelland, Kent L. Hill

Nucleoporin 153 Arrests the Nuclear Import of Hepatitis B Virus Capsids in the Nuclear Basket

André Schmitz, Alexandra Schwarz, Michael Foss, Lixin Zhou, Birgit Rabe, Julia Hoellenriegel, Miriam Stoeber, Nelly Panté, Michael Kann

Upregulation of xCT by KSHV-Encoded microRNAs Facilitates KSHV Dissemination and Persistence in an Environment of Oxidative Stress

Zhiqiang Qin, Eduardo Freitas, Roger Sullivan, Sarumathi Mohan, Rocky Bacelieri, Drake Branch, Margaret Romano, Patricia Kearney, Jim Oates, Karlie Plaisance, Rolf Renne, Johnan Kaleeba, Chris Parsons

The Type III Secretion Effector NleE Inhibits NF-κB Activation

Chen Nadler, Kobi Baruch, Simi Kobi, Erez Mills, Gili Haviv, Marganit Farago, Irit Alkalay, Sina Bartfeld, Thomas F. Meyer, Yinon Ben-Neriah, Ilan Rosenshine

Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

Kevin N. Couper, Tom Barnes, Julius C. R. Hafalla, Valery Combes, Bernhard Ryffel, Thomas Secher, Georges E. Grau, Eleanor M. Riley, J. Brian de Souza

Protection of Mice against Lethal Challenge with 2009 H1N1 Influenza A Virus by 1918-Like and Classical Swine H1N1 Based Vaccines

Balaji Manicassamy, Rafael A. Medina, Rong Hai, Tshidi Tsibane, Silke Stertz, Estanislao Nistal-Villán, Peter Palese, Christopher F. Basler, Adolfo García-Sastre

CD8+ Lymphocytes Control Viral Replication in SIVmac239-Infected Rhesus Macaques without Decreasing the Lifespan of Productively Infected Cells

Nichole R. Klatt, Emi Shudo, Alex M. Ortiz, Jessica C. Engram, Mirko Paiardini, Benton Lawson, Michael D. Miller, James Else, Ivona Pandrea, Jacob D. Estes, Cristian Apetrei, Joern E. Schmitz, Ruy M. Ribeiro, Alan S. Perelson, Guido Silvestri

In Vivo CD8+ T-Cell Suppression of SIV Viremia Is Not Mediated by CTL Clearance of Productively Infected Cells

Joseph K. Wong, Matthew C. Strain, Rodin Porrata, Elizabeth Reay, Sumathi Sankaran-Walters, Caroline C. Ignacio, Theresa Russell, Satish K. Pillai, David J. Looney, Satya Dandekar

Persistent ER Stress Induces the Spliced Leader RNA Silencing Pathway (SLS), Leading to Programmed Cell Death in Trypanosoma brucei

Hanoch Goldshmidt, Devorah Matas, Anat Kabi, Shai Carmi, Ronen Hope, Shulamit Michaeli

Placental Syncytiotrophoblast Constitutes a Major Barrier to Vertical Transmission of Listeria monocytogenes

Jennifer R. Robbins, Kasia M. Skrzypczynska, Varvara B. Zeldovich, Mirhan Kapidzic, Anna I. Bakardjiev

Polyoma Virus-Induced Osteosarcomas in Inbred Strains of Mice: Host Determinants of Metastasis

Palanivel Velupillai, Chang Kyoo Sung, Yu Tian, Jean Dahl, John Carroll, Roderick Bronson, Thomas Benjamin

Melanoma Differentiation-Associated Gene 5 (MDA5) Is Involved in the Innate Immune Response to Paramyxoviridae Infection In Vivo

Leonid Gitlin, Loralyn Benoit, Christina Song, Marina Cella, Susan Gilfillan, Michael J. Holtzman, Marco Colonna

Evolutionary Trajectories of Beta-Lactamase CTX-M-1 Cluster Enzymes: Predicting Antibiotic Resistance

Ângela Novais, Iñaki Comas, Fernando Baquero, Rafael Cantón, Teresa M. Coque, Andrés Moya, Fernando González-Candelas, Juan-Carlos Galán

Protease-Sensitive Synthetic Prions

David W. Colby, Rachel Wain, Ilia V. Baskakov, Giuseppe Legname, Christina G. Palmer, Hoang-Oanh B. Nguyen, Azucena Lemus, Fred E. Cohen, Stephen J. DeArmond, Stanley B. Prusiner

Histone Deacetylases Play a Major Role in the Transcriptional Regulation of the Plasmodium falciparum Life Cycle

Balbir K. Chaal, Archna P. Gupta, Brigitta D. Wastuwidyaningtyas, Yen-Hoon Luah, Zbynek Bozdech

TRIM5α Modulates Immunodeficiency Virus Control in Rhesus Monkeys

So-Yon Lim, Thomas Rogers, Tiffany Chan, James B. Whitney, Jonghwa Kim, Joseph Sodroski, Norman L. Letvin

A Small-Molecule Inhibitor of T. gondii Motility Induces the Posttranslational Modification of Myosin Light Chain-1 and Inhibits Myosin Motor Activity

Aoife T. Heaslip, Jacqueline M. Leung, Kimberly L. Carey, Federica Catti, David M. Warshaw, Nicholas J. Westwood, Bryan A. Ballif, Gary E. Ward

Marburg Virus Evades Interferon Responses by a Mechanism Distinct from Ebola Virus

Charalampos Valmas, Melanie N. Grosch, Michael Schümann, Judith Olejnik, Osvaldo Martinez, Sonja M. Best, Verena Krähling, Christopher F. Basler, Elke Mühlberger

Type I Interferon Induction Is Detrimental during Infection with the Whipple's Disease Bacterium, Tropheryma whipplei

Khatoun Al Moussawi, Eric Ghigo, Ulrich Kalinke, Lena Alexopoulou, Jean-Louis Mege, Benoit Desnues

B Cell Activation by Outer Membrane Vesicles—A Novel Virulence Mechanism

Maria Laura A. Perez Vidakovics, Johan Jendholm, Matthias Mörgelin, Anne Månsson, Christer Larsson, Lars-Olaf Cardell, Kristian Riesbeck

Within-Host Evolution of Burkholderia pseudomallei in Four Cases of Acute Melioidosis

Erin P. Price, Heidie M. Hornstra, Direk Limmathurotsakul, Tamara L. Max, Derek S. Sarovich, Amy J. Vogler, Julia L. Dale, Jennifer L. Ginther, Benjamin Leadem, Rebecca E. Colman, Jeffrey T. Foster, Apichai Tuanyok, David M. Wagner, Sharon J. Peacock, Talima Pearson, Paul Keim

β-Neurexin Is a Ligand for the Staphylococcus aureus MSCRAMM SdrC

E. Magda Barbu, Vannakambadi K. Ganesh, Shivasankarappa Gurusiddappa, R. Chris Mackenzie, Timothy J. Foster, Thomas C. Sudhof, Magnus Höök

Two Plant Viral Suppressors of Silencing Require the Ethylene-Inducible Host Transcription Factor RAV2 to Block RNA Silencing

Matthew W. Endres, Brian D. Gregory, Zhihuan Gao, Amy Wahba Foreman, Sizolwenkosi Mlotshwa, Xin Ge, Gail J. Pruss, Joseph R. Ecker, Lewis H. Bowman, Vicki Vance

The M/GP5 Glycoprotein Complex of Porcine Reproductive and Respiratory Syndrome Virus Binds the Sialoadhesin Receptor in a Sialic Acid-Dependent Manner

Wander Van Breedam, Hanne Van Gorp, Jiquan Q. Zhang, Paul R. Crocker, Peter L. Delputte, Hans J. Nauwynck

Like Will to Like: Abundances of Closely Related Species Can Predict Susceptibility to Intestinal Colonization by Pathogenic and Commensal Bacteria

Bärbel Stecher, Samuel Chaffron, Rina Käppeli, Siegfried Hapfelmeier, Susanne Freedrich, Thomas C. Weber, Jorum Kirundi, Mrutyunjay Suar, Kathy D. McCoy, Christian von Mering, Andrew J. Macpherson, Wolf-Dietrich Hardt

Nutrient Availability as a Mechanism for Selection of Antibiotic Tolerant Pseudomonas aeruginosa within the CF Airway

Lucas R. Hoffman, Anthony R. Richardson, Laura S. Houston, Hemantha D. Kulasekara, Willm Martens-Habbena, Mikkel Klausen, Jane L. Burns, David A. Stahl, Daniel J. Hassett, Ferric C. Fang, Samuel I. Miller

Characterization of the Oral Fungal Microbiome (Mycobiome) in Healthy Individuals

Mahmoud A. Ghannoum, Richard J. Jurevic, Pranab K. Mukherjee, Fan Cui, Masoumeh Sikaroodi, Ammar Naqvi, Patrick M. Gillevet

PPARγ Controls Dectin-1 Expression Required for Host Antifungal Defense against Candida albicans

Amandine Galès, Annabelle Conduché, José Bernad, Lise Lefevre, David Olagnier, Maryse Béraud, Guillaume Martin-Blondel, Marie-Denise Linas, Johan Auwerx, Agnès Coste, Bernard Pipy

Staphylococcus aureus Panton-Valentine Leukocidin Is a Very Potent Cytotoxic Factor for Human Neutrophils

Bettina Löffler, Muzaffar Hussain, Matthias Grundmeier, Michaela Brück, Dirk Holzinger, Georg Varga, Johannes Roth, Barbara C. Kahl, Richard A. Proctor, Georg Peters

Caenorhabditis elegans N-glycan Core β-galactoside Confers Sensitivity towards Nematotoxic Fungal Galectin CGL2

Alex Butschi, Alexander Titz, Martin A. Wälti, Vincent Olieric, Katharina Paschinger, Katharina Nöbauer, Xiaoqiang Guo, Peter H. Seeberger, Iain B. H. Wilson, Markus Aebi, Michael O. Hengartner, Markus Künzler

Immature Dengue Virus: A Veiled Pathogen?

Izabela A. Rodenhuis-Zybert, Hilde M. van der Schaar, Júlia M. da Silva Voorham, Heidi van der Ende-Metselaar, Huan-Yao Lei, Jan Wilschut, Jolanda M. Smit

Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics

Deborah L. Diamond, Andrew J. Syder, Jon M. Jacobs, Christina M. Sorensen, Kathie-Anne Walters, Sean C. Proll, Jason E. McDermott, Marina A. Gritsenko, Qibin Zhang, Rui Zhao, Thomas O. Metz, David G. Camp II, Katrina M. Waters, Richard D. Smith, Charles M. Rice, Michael G. Katze