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Table of Contents: March 2010

Issue Image

Cells have a number of intracellular sensors that mediate dsRNA-induced antiviral responses. DeWitte-Orr et al. (doi:10.1371/journal.ppat.1000829) report that SR-As mediate entry of extracellular dsRNA at the cell surface, and subsequently deliver the dsRNA to the classic intracellular pathways. In this image, Alexafluor 488 labelled, in vitro transcribed dsRNA based from the West Nile virus genome (1,000 bp) is taken up by MEFs. The nucleus of the cell is stained with Hoescht 33258.

Opinion

Pearls

Review

HIV and Mature Dendritic Cells: Trojan Exosomes Riding the Trojan Horse?

Nuria Izquierdo-Useros, Mar Naranjo-Gómez, Itziar Erkizia, Maria Carmen Puertas, Francesc E. Borràs, Julià Blanco, Javier Martinez-Picado

Research Articles

Exoerythrocytic Plasmodium Parasites Secrete a Cysteine Protease Inhibitor Involved in Sporozoite Invasion and Capable of Blocking Cell Death of Host Hepatocytes

Annika Rennenberg, Christine Lehmann, Anna Heitmann, Tina Witt, Guido Hansen, Krishna Nagarajan, Christina Deschermeier, Vito Turk, Rolf Hilgenfeld, Volker T. Heussler

Inhibition of Macrophage Migration Inhibitory Factor Ameliorates Ocular Pseudomonas aeruginosa-Induced Keratitis

Mihaela Gadjeva, Jill Nagashima, Tanweer Zaidi, Robert A. Mitchell, Gerald B. Pier

Serological Profiling of a Candida albicans Protein Microarray Reveals Permanent Host-Pathogen Interplay and Stage-Specific Responses during Candidemia

A. Brian Mochon, Jin Ye, Matthew A. Kayala, John R. Wingard, Cornelius J. Clancy, M. Hong Nguyen, Philip Felgner, Pierre Baldi, Haoping Liu

Dispersion as an Important Step in the Candida albicans Biofilm Developmental Cycle

Priya Uppuluri, Ashok K. Chaturvedi, Anand Srinivasan, Mohua Banerjee, Anand K. Ramasubramaniam, Julia R. Köhler, David Kadosh, Jose L. Lopez-Ribot

Origin and Evolution of Sulfadoxine Resistant Plasmodium falciparum

Sumiti Vinayak, Md Tauqeer Alam, Tonya Mixson-Hayden, Andrea M. McCollum, Rithy Sem, Naman K. Shah, Pharath Lim, Sinuon Muth, William O. Rogers, Thierry Fandeur, John W. Barnwell, Ananias A. Escalante, Chansuda Wongsrichanalai, Frederick Ariey, Steven R. Meshnick, Venkatachalam Udhayakumar

Rapid Evolution of Pandemic Noroviruses of the GII.4 Lineage

Rowena A. Bull, John-Sebastian Eden, William D. Rawlinson, Peter A. White

T Cell-Dependence of Lassa Fever Pathogenesis

Lukas Flatz, Toni Rieger, Doron Merkler, Andreas Bergthaler, Tommy Regen, Mariann Schedensack, Lukas Bestmann, Admar Verschoor, Mario Kreutzfeldt, Wolfgang Brück, Uwe-Karsten Hanisch, Stephan Günther, Daniel D. Pinschewer

A Capsid-Encoded PPxY-Motif Facilitates Adenovirus Entry

Harald Wodrich, Daniel Henaff, Baptist Jammart, Carolina Segura-Morales, Sigrid Seelmeir, Olivier Coux, Zsolt Ruzsics, Christopher M. Wiethoff, Eric J. Kremer

The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica

Pavel Dolezal, Michael J. Dagley, Maya Kono, Peter Wolynec, Vladimir A. Likić, Jung Hock Foo, Miroslava Sedinová, Jan Tachezy, Anna Bachmann, Iris Bruchhaus, Trevor Lithgow

Differential Regulation of Effector- and Central-Memory Responses to Toxoplasma gondii Infection by IL-12 Revealed by Tracking of Tgd057-Specific CD8+ T Cells

Douglas C. Wilson, Gijsbert M. Grotenbreg, Kenian Liu, Yanlin Zhao, Eva-Maria Frickel, Marc-Jan Gubbels, Hidde L. Ploegh, George S. Yap

A Combination of Independent Transcriptional Regulators Shapes Bacterial Virulence Gene Expression during Infection

Samuel A. Shelburne, Randall J. Olsen, Bryce Suber, Pranoti Sahasrabhojane, Paul Sumby, Richard G. Brennan, James M. Musser

Nucleophosmin Phosphorylation by v-Cyclin-CDK6 Controls KSHV Latency

Grzegorz Sarek, Annika Järviluoma, Henna M. Moore, Sari Tojkander, Salla Vartia, Peter Biberfeld, Marikki Laiho, Päivi M. Ojala

Helicobacter pylori Lipopolysaccharide Is Synthesized via a Novel Pathway with an Evolutionary Connection to Protein N-Glycosylation

Isabelle Hug, Marc R. Couturier, Michelle M. Rooker, Diane E. Taylor, Markus Stein, Mario F. Feldman

MicroRNA Antagonism of the Picornaviral Life Cycle: Alternative Mechanisms of Interference

Elizabeth J. Kelly, Elizabeth M. Hadac, Bryan R. Cullen, Stephen J. Russell

Natural Strain Variation and Antibody Neutralization of Dengue Serotype 3 Viruses

Wahala M. P. B. Wahala, Eric F. Donaldson, Ruklanthi de Alwis, Mary Ann Accavitti-Loper, Ralph S. Baric, Aravinda M. de Silva

Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila Effector

Li Xu, Xihui Shen, Andrew Bryan, Simran Banga, Michele S. Swanson, Zhao-Qing Luo

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin

Tadaki Suzuki, Yasuko Orba, Yuki Okada, Yuji Sunden, Takashi Kimura, Shinya Tanaka, Kazuo Nagashima, William W. Hall, Hirofumi Sawa

Membrane Damage Elicits an Immunomodulatory Program in Staphylococcus aureus

Ahmed S. Attia, Meredith A. Benson, Devin L. Stauff, Victor J. Torres, Eric P. Skaar

YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa

Jacob G. Malone, Tina Jaeger, Christian Spangler, Daniel Ritz, Anne Spang, Cécile Arrieumerlou, Volkhard Kaever, Regine Landmann, Urs Jenal

Dynamic Imaging of Experimental Leishmania donovani-Induced Hepatic Granulomas Detects Kupffer Cell-Restricted Antigen Presentation to Antigen-Specific CD8+ T Cells

Lynette Beattie, Adam Peltan, Asher Maroof, Alun Kirby, Najmeeyah Brown, Mark Coles, Deborah F. Smith, Paul M. Kaye

N-Acetylglucosamine Induces White to Opaque Switching, a Mating Prerequisite in Candida albicans

Guanghua Huang, Song Yi, Nidhi Sahni, Karla J. Daniels, Thyagarajan Srikantha, David R. Soll

Structural Basis of Cell Wall Cleavage by a Staphylococcal Autolysin

Sebastian Zoll, Bernhard Pätzold, Martin Schlag, Friedrich Götz, Hubert Kalbacher, Thilo Stehle

Staphylococcus aureus RNAIII Binds to Two Distant Regions of coa mRNA to Arrest Translation and Promote mRNA Degradation

Clément Chevalier, Sandrine Boisset, Cédric Romilly, Benoit Masquida, Pierre Fechter, Thomas Geissmann, François Vandenesch, Pascale Romby

Homeostatic Interplay between Bacterial Cell-Cell Signaling and Iron in Virulence

Ronen Hazan, Jianxin He, Gaoping Xiao, Valérie Dekimpe, Yiorgos Apidianakis, Biliana Lesic, Christos Astrakas, Eric Déziel, François Lépine, Laurence G. Rahme

Innate Killing of Leishmania donovani by Macrophages of the Splenic Marginal Zone Requires IRF-7

Rebecca Phillips, Mattias Svensson, Naveed Aziz, Asher Maroof, Najmeeyah Brown, Lynette Beattie, Nathalie Signoret, Paul M. Kaye

Direct Restriction of Virus Release and Incorporation of the Interferon-Induced Protein BST-2 into HIV-1 Particles

Kathleen Fitzpatrick, Mark Skasko, Thomas J. Deerinck, John Crum, Mark H. Ellisman, John Guatelli

Endocytosis of the Anthrax Toxin Is Mediated by Clathrin, Actin and Unconventional Adaptors

Laurence Abrami, Mirko Bischofberger, Béatrice Kunz, Romain Groux, F. Gisou van der Goot

Tsetse EP Protein Protects the Fly Midgut from Trypanosome Establishment

Lee R. Haines, Stella M. Lehane, Terry W. Pearson, Michael J. Lehane

Direct Visualization by Cryo-EM of the Mycobacterial Capsular Layer: A Labile Structure Containing ESX-1-Secreted Proteins

Musa Sani, Edith N. G. Houben, Jeroen Geurtsen, Jason Pierson, Karin de Punder, Maaike van Zon, Brigitte Wever, Sander R. Piersma, Connie R. Jiménez, Mamadou Daffé, Ben J. Appelmelk, Wilbert Bitter, Nicole van der Wel, Peter J. Peters

Perforin and IL-2 Upregulation Define Qualitative Differences among Highly Functional Virus-Specific Human CD8+ T Cells

George Makedonas, Natalie Hutnick, Danielle Haney, Alexandra C. Amick, Jay Gardner, Gabriela Cosma, Adam R. Hersperger, Douglas Dolfi, E. John Wherry, Guido Ferrari, Michael R. Betts

Fatal Transmissible Amyloid Encephalopathy: A New Type of Prion Disease Associated with Lack of Prion Protein Membrane Anchoring

Bruce Chesebro, Brent Race, Kimberly Meade-White, Rachel LaCasse, Richard Race, Mikael Klingeborn, James Striebel, David Dorward, Gillian McGovern, Martin Jeffrey