Advertisement

Table of Contents: February 2011

Issue Image

This fli1:GFP transgenic zebrafish larva has been inoculated with Infectious Hematopoietic Necrosis Virus (IHNV), fixed 24 hours later, processed for whole-mount immunohistochemistry, and imaged with a confocal microscope to reveal virus-infected cells (anti-G-IHNV antibody, red), endothelial cells (GFP, green), and nuclei (blue). Infection of several vessels can be observed, especially at the top of the head, where loss of GFP expression has occurred, as well as infection of neighboring tissue. Although at this stage the larva does not display obvious macroscopic signs of disease, it is already doomed (see Ludwig et al., doi:10.1371/journal.ppat.1001269).

Opinion

Pearls

Review

A Fresh Look at the Origin of Plasmodium falciparum, the Most Malignant Malaria Agent

Franck Prugnolle, Patrick Durand, Benjamin Ollomo, Linda Duval, Frédéric Ariey, Céline Arnathau, Jean-Paul Gonzalez, Eric Leroy, François Renaud

Research Articles

Uropathogenic Escherichia coli P and Type 1 Fimbriae Act in Synergy in a Living Host to Facilitate Renal Colonization Leading to Nephron Obstruction

Keira Melican, Ruben M. Sandoval, Abdul Kader, Lina Josefsson, George A. Tanner, Bruce A. Molitoris, Agneta Richter-Dahlfors

The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding Module

Luke J. Alderwick, Georgina S. Lloyd, Hemza Ghadbane, John W. May, Apoorva Bhatt, Lothar Eggeling, Klaus Fütterer, Gurdyal S. Besra

Elite Suppressors Harbor Low Levels of Integrated HIV DNA and High Levels of 2-LTR Circular HIV DNA Compared to HIV+ Patients On and Off HAART

Erin H. Graf, Angela M. Mexas, Jianqing J. Yu, Farida Shaheen, Megan K. Liszewski, Michele Di Mascio, Stephen A. Migueles, Mark Connors, Una O'Doherty

The Genotype of Early-Transmitting HIV gp120s Promotes α4β7 –Reactivity, Revealing α4β7+/CD4+ T cells As Key Targets in Mucosal Transmission

Fatima Nawaz, Claudia Cicala, Donald Van Ryk, Katharine E. Block, Katija Jelicic, Jonathan P. McNally, Olajumoke Ogundare, Massimiliano Pascuccio, Nikita Patel, Danlan Wei, Anthony S. Fauci, James Arthos

The bZIP Transcription Factor MoAP1 Mediates the Oxidative Stress Response and Is Critical for Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae

Min Guo, Yue Chen, Yan Du, Yanhan Dong, Wang Guo, Su Zhai, Haifeng Zhang, Suomeng Dong, Zhengguang Zhang, Yuanchao Wang, Ping Wang, Xiaobo Zheng

Episomal Viral cDNAs Identify a Reservoir That Fuels Viral Rebound after Treatment Interruption and That Contributes to Treatment Failure

Mark Sharkey, Dunja Z. Babic, Thomas Greenough, Roy Gulick, Daniel R. Kuritzkes, Mario Stevenson

Type I Interferon Signaling Regulates Ly6Chi Monocytes and Neutrophils during Acute Viral Pneumonia in Mice

Sang-Uk Seo, Hyung-Joon Kwon, Hyun-Jeong Ko, Young-Ho Byun, Baik Lin Seong, Satoshi Uematsu, Shizuo Akira, Mi-Na Kweon

Critical Role of the Virus-Encoded MicroRNA-155 Ortholog in the Induction of Marek's Disease Lymphomas

Yuguang Zhao, Hongtao Xu, Yongxiu Yao, Lorraine P. Smith, Lydia Kgosana, James Green, Lawrence Petherbridge, Susan J. Baigent, Venugopal Nair

Trivalent Adenovirus Type 5 HIV Recombinant Vaccine Primes for Modest Cytotoxic Capacity That Is Greatest in Humans with Protective HLA Class I Alleles

Stephen A. Migueles, Julia E. Rood, Amy M. Berkley, Tiffany Guo, Daniel Mendoza, Andy Patamawenu, Claire W. Hallahan, Nancy A. Cogliano, Nicole Frahm, Ann Duerr, M. Juliana McElrath, Mark Connors

Innate Sensing of HIV-Infected Cells

Alice Lepelley, Stéphanie Louis, Marion Sourisseau, Helen K. W. Law, Julien Pothlichet, Clémentine Schilte, Laurence Chaperot, Joël Plumas, Richard E. Randall, Mustapha Si-Tahar, Fabrizio Mammano, Matthew L. Albert, Olivier Schwartz

Phosphatidylinositol 3-Monophosphate Is Involved in Toxoplasma Apicoplast Biogenesis

Lina Tawk, Jean-François Dubremetz, Philippe Montcourrier, Gaëtan Chicanne, Fabrice Merezegue, Véronique Richard, Bernard Payrastre, Markus Meissner, Henri J. Vial, Christian Roy, Kai Wengelnik, Maryse Lebrun

Targeted Disruption of py235ebp-1: Invasion of Erythrocytes by Plasmodium yoelii Using an Alternative Py235 Erythrocyte Binding Protein

Solabomi A. Ogun, Rita Tewari, Thomas D. Otto, Steven A. Howell, Ellen Knuepfer, Deirdre A. Cunningham, Zhengyao Xu, Arnab Pain, Anthony A. Holder

Expression of P. falciparum var Genes Involves Exchange of the Histone Variant H2A.Z at the Promoter

Michaela Petter, Chin Chin Lee, Timothy J. Byrne, Katja E. Boysen, Jennifer Volz, Stuart A. Ralph, Alan F. Cowman, Graham V. Brown, Michael F. Duffy

Genital Tract Sequestration of SIV following Acute Infection

James B. Whitney, Peter T. Hraber, Corinne Luedemann, Elena E. Giorgi, Marcus G. Daniels, Tanmoy Bhattacharya, Srinivas S. Rao, John R. Mascola, Gary J. Nabel, Bette T. Korber, Norman L. Letvin

A Viral microRNA Cluster Strongly Potentiates the Transforming Properties of a Human Herpesvirus

Regina Feederle, Sarah D. Linnstaedt, Helmut Bannert, Helge Lips, Maja Bencun, Bryan R. Cullen, Henri-Jacques Delecluse

DNA Damage and Reactive Nitrogen Species are Barriers to Vibrio cholerae Colonization of the Infant Mouse Intestine

Bryan W. Davies, Ryan W. Bogard, Nicole M. Dupes, Tyler A. I. Gerstenfeld, Lyle A. Simmons, John J. Mekalanos

Wolbachia Infections in Anopheles gambiae Cells: Transcriptomic Characterization of a Novel Host-Symbiont Interaction

Grant L. Hughes, Xiaoxia Ren, Jose L. Ramirez, Joyce M. Sakamoto, Jason A. Bailey, Anne E. Jedlicka, Jason L. Rasgon

STAT2 Mediates Innate Immunity to Dengue Virus in the Absence of STAT1 via the Type I Interferon Receptor

Stuart T. Perry, Michael D. Buck, Steven M. Lada, Christian Schindler, Sujan Shresta

Compensatory Evolution of pbp Mutations Restores the Fitness Cost Imposed by β-Lactam Resistance in Streptococcus pneumoniae

Andrea G. Albarracín Orio, Germán E. Piñas, Paulo R. Cortes, Melina B. Cian, José Echenique

Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection

Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, Kent J. Weinhold

HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo

Yorifumi Satou, Jun-ichirou Yasunaga, Tiejun Zhao, Mika Yoshida, Paola Miyazato, Ken Takai, Kei Shimizu, Koichi Ohshima, Patrick L. Green, Naganari Ohkura, Tomoyuki Yamaguchi, Masahiro Ono, Shimon Sakaguchi, Masao Matsuoka

Epstein-Barr Virus Nuclear Antigen 3C Facilitates G1-S Transition by Stabilizing and Enhancing the Function of Cyclin D1

Abhik Saha, Sabyasachi Halder, Santosh K. Upadhyay, Jie Lu, Pankaj Kumar, Masanao Murakami, Qiliang Cai, Erle S. Robertson

The RON2-AMA1 Interaction is a Critical Step in Moving Junction-Dependent Invasion by Apicomplexan Parasites

Mauld Lamarque, Sébastien Besteiro, Julien Papoin, Magali Roques, Brigitte Vulliez-Le Normand, Juliette Morlon-Guyot, Jean-François Dubremetz, Sylvain Fauquenoy, Stanislas Tomavo, Bart W. Faber, Clemens H. Kocken, Alan W. Thomas, Martin J. Boulanger, Graham A. Bentley, Maryse Lebrun

Highly Efficient Protein Misfolding Cyclic Amplification

Nuria Gonzalez-Montalban, Natallia Makarava, Valeriy G. Ostapchenko, Regina Savtchenk, Irina Alexeeva, Robert G. Rohwer, Ilia V. Baskakov

NS2 Protein of Hepatitis C Virus Interacts with Structural and Non-Structural Proteins towards Virus Assembly

Costin-Ioan Popescu, Nathalie Callens, Dave Trinel, Philippe Roingeard, Darius Moradpour, Véronique Descamps, Gilles Duverlie, François Penin, Laurent Héliot, Yves Rouillé, Jean Dubuisson

Genetic Mapping Identifies Novel Highly Protective Antigens for an Apicomplexan Parasite

Damer P. Blake, Karen J. Billington, Susan L. Copestake, Richard D. Oakes, Michael A. Quail, Kiew-Lian Wan, Martin W. Shirley, Adrian L. Smith

Functional Coupling between HIV-1 Integrase and the SWI/SNF Chromatin Remodeling Complex for Efficient in vitro Integration into Stable Nucleosomes

Paul Lesbats, Yair Botbol, Guillaume Chevereau, Cédric Vaillant, Christina Calmels, Alain Arneodo, Marie-Line Andreola, Marc Lavigne, Vincent Parissi

Short-Lived IFN-γ Effector Responses, but Long-Lived IL-10 Memory Responses, to Malaria in an Area of Low Malaria Endemicity

Jiraprapa Wipasa, Lucy Okell, Supachai Sakkhachornphop, Chaisuree Suphavilai, Kriangkrai Chawansuntati, Witaya Liewsaree, Julius C. R. Hafalla, Eleanor M. Riley

Atypical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues

Olivier Andréoletti, Leonor Orge, Sylvie L. Benestad, Vincent Beringue, Claire Litaise, Stéphanie Simon, Annick Le Dur, Hubert Laude, Hugh Simmons, Séverine Lugan, Fabien Corbière, Pierrette Costes, Nathalie Morel, François Schelcher, Caroline Lacroux

Small Molecule Inhibitors of Staphylococcus aureus RnpA Alter Cellular mRNA Turnover, Exhibit Antimicrobial Activity, and Attenuate Pathogenesis

Patrick D. Olson, Lisa J. Kuechenmeister, Kelsi L. Anderson, Sonja Daily, Karen E. Beenken, Christelle M. Roux, Michelle L. Reniere, Tami L. Lewis, William J. Weiss, Mark Pulse, Phung Nguyen, Jerry W. Simecka, John M. Morrison, Khalid Sayood, Oluwatoyin A. Asojo, Mark S. Smeltzer, Eric P. Skaar, Paul M. Dunman

The ESCRT-0 Component HRS is Required for HIV-1 Vpu-Mediated BST-2/Tetherin Down-Regulation

Katy Janvier, Annegret Pelchen–Matthews, Jean-Baptiste Renaud, Marina Caillet, Mark Marsh, Clarisse Berlioz-Torrent

Entrapment of Viral Capsids in Nuclear PML Cages Is an Intrinsic Antiviral Host Defense against Varicella-Zoster Virus

Mike Reichelt, Li Wang, Marvin Sommer, John Perrino, Adel M. Nour, Nandini Sen, Armin Baiker, Leigh Zerboni, Ann M. Arvin

Transcription and Translation Products of the Cytolysin Gene psm-mec on the Mobile Genetic Element SCCmec Regulate Staphylococcus aureus Virulence

Chikara Kaito, Yuki Saito, Gentaro Nagano, Mariko Ikuo, Yosuke Omae, Yuichi Hanada, Xiao Han, Kyoko Kuwahara-Arai, Tomomi Hishinuma, Tadashi Baba, Teruyo Ito, Keiichi Hiramatsu, Kazuhisa Sekimizu

Whole-Body Analysis of a Viral Infection: Vascular Endothelium is a Primary Target of Infectious Hematopoietic Necrosis Virus in Zebrafish Larvae

Marion Ludwig, Nuno Palha, Corinne Torhy, Valérie Briolat, Emma Colucci-Guyon, Michel Brémont, Philippe Herbomel, Pierre Boudinot, Jean-Pierre Levraud

Positive Signature-Tagged Mutagenesis in Pseudomonas aeruginosa: Tracking Patho-Adaptive Mutations Promoting Airways Chronic Infection

Irene Bianconi, Andrea Milani, Cristina Cigana, Moira Paroni, Roger C. Levesque, Giovanni Bertoni, Alessandra Bragonzi

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

Ross Vlahos, John Stambas, Steven Bozinovski, Brad R. S. Broughton, Grant R. Drummond, Stavros Selemidis