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Table of Contents: March 2011

COVER

Image Credit: Anja Kipar, University of Liverpool
Issue Image
Localization of murine gammaherpesvirus 68 M3 transcripts in lung tissue.

Wood mice (Apodemus sylvaticus) are a natural host for murine gammaherpesvirus 68 (MHV-68). A captive-bred wood mouse was infected intranasally with MHV-68. At day 7 post-infection, lung tissue was analyzed by RNA in situ hybridisation using probes specific for the MHV-68 M3 open reading frame, which encodes a viral chemokine binding protein. M3 transcripts (dark purple signals) were detected within lymphocytes in perivascular infiltrates and circulating lymphocytes attached to endothelial cells of an artery (see Hughes et al., doi:10.1371/journal.ppat.1001321).

Pearls

Viral Encephalomyelitis

Diane E. Griffin

Review

The Staphylococcus aureus RNome and Its Commitment to Virulence

Brice Felden, François Vandenesch, Philippe Bouloc, Pascale Romby

Research Articles

The Lectin Receptor Kinase LecRK-I.9 Is a Novel Phytophthora Resistance Component and a Potential Host Target for a RXLR Effector

Klaas Bouwmeester, Mara de Sain, Rob Weide, Anne Gouget, Sofieke Klamer, Herve Canut, Francine Govers

A Novel Toxoplasma gondii Nuclear Factor TgNF3 Is a Dynamic Chromatin-Associated Component, Modulator of Nucleolar Architecture and Parasite Virulence

Alejandro Olguin-Lamas, Edwige Madec, Agnes Hovasse, Elisabeth Werkmeister, Isabelle Callebaut, Christian Slomianny, Stephane Delhaye, Thomas Mouveaux, Christine Schaeffer-Reiss, Alain Van Dorsselaer, Stanislas Tomavo

Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway

Erik de Vries, Donna M. Tscherne, Marleen J. Wienholts, Viviana Cobos-Jiménez, Florine Scholte, Adolfo García-Sastre, Peter J. M. Rottier, Cornelis A. M. de Haan

Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

Lisheng Peng, William H. Tepp, Eric A. Johnson, Min Dong

The Stealth Episome: Suppression of Gene Expression on the Excised Genomic Island PPHGI-1 from Pseudomonas syringae pv. phaseolicola

Scott A. C. Godfrey, Helen C. Lovell, John W. Mansfield, David S. Corry, Robert W. Jackson, Dawn L. Arnold

Novel Escape Mutants Suggest an Extensive TRIM5α Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid Protein

Sadayuki Ohkura, David C. Goldstone, Melvyn W. Yap, Kate Holden-Dye, Ian A. Taylor, Jonathan P. Stoye

Metabolite Cross-Feeding Enhances Virulence in a Model Polymicrobial Infection

Matthew M. Ramsey, Kendra P. Rumbaugh, Marvin Whiteley

Lung Adenocarcinoma Originates from Retrovirus Infection of Proliferating Type 2 Pneumocytes during Pulmonary Post-Natal Development or Tissue Repair

Claudio Murgia, Marco Caporale, Ousman Ceesay, Gabriella Di Francesco, Nicola Ferri, Vincenzo Varasano, Marcelo de las Heras, Massimo Palmarini

A Pseudomonas aeruginosa Toxin that Hijacks the Host Ubiquitin Proteolytic System

Jennifer M. Bomberger, Siying Ye, Daniel P. MacEachran, Katja Koeppen, Roxanna L. Barnaby, George A. O'Toole, Bruce A. Stanton

Dynamic Imaging of the Effector Immune Response to Listeria Infection In Vivo

Janelle C. Waite, Ingrid Leiner, Peter Lauer, Chris S. Rae, Gaetan Barbet, Huan Zheng, Daniel A. Portnoy, Eric G. Pamer, Michael L. Dustin

Rhesus TRIM5α Disrupts the HIV-1 Capsid at the Inter­Hexamer Interfaces

Gongpu Zhao, Danxia Ke, Thomas Vu, Jinwoo Ahn, Vaibhav B. Shah, Ruifeng Yang, Christopher Aiken, Lisa M. Charlton, Angela M. Gronenborn, Peijun Zhang

The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

Jacob I. Ayers, Charles R. Schutt, Ronald A. Shikiya, Adriano Aguzzi, Anthony E. Kincaid, Jason C. Bartz

Dendritic Cells and Hepatocytes Use Distinct Pathways to Process Protective Antigen from Plasmodium in vivo

Ian A. Cockburn, Sze-Wah Tse, Andrea J. Radtke, Prakash Srinivasan, Yun-Chi Chen, Photini Sinnis, Fidel Zavala

Sheep and Goat BSE Propagate More Efficiently than Cattle BSE in Human PrP Transgenic Mice

Danielle Padilla, Vincent Béringue, Juan Carlos Espinosa, Olivier Andreoletti, Emilie Jaumain, Fabienne Reine, Laetitia Herzog, Alfonso Gutierrez-Adan, Belen Pintado, Hubert Laude, Juan Maria Torres

Blood Meal-Derived Heme Decreases ROS Levels in the Midgut of Aedes aegypti and Allows Proliferation of Intestinal Microbiota

Jose Henrique M. Oliveira, Renata L. S. Gonçalves, Flavio A. Lara, Felipe A. Dias, Ana Caroline P. Gandara, Rubem F. S. Menna-Barreto, Meredith C. Edwards, Francisco R. M. Laurindo, Mário A. C. Silva-Neto, Marcos H. F. Sorgine, Pedro L. Oliveira

Chemokine Binding Protein M3 of Murine Gammaherpesvirus 68 Modulates the Host Response to Infection in a Natural Host

David J. Hughes, Anja Kipar, Gail H. Leeming, Elaine Bennett, Deborah Howarth, Joanne A. Cummerson, Rita Papoula-Pereira, Brian F. Flanagan, Jeffery T. Sample, James P. Stewart

Multiple Helminth Infection of the Skin Causes Lymphocyte Hypo-Responsiveness Mediated by Th2 Conditioning of Dermal Myeloid Cells

Peter C. Cook, Sarah A. Aynsley, Joseph D. Turner, Gavin R. Jenkins, Nico Van Rooijen, Mosiuoa Leeto, Frank Brombacher, Adrian P. Mountford

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

Amitava Mukherjee, Stefanie A. Morosky, Elizabeth Delorme-Axford, Naomi Dybdahl-Sissoko, M. Steven Oberste, Tianyi Wang, Carolyn B. Coyne

Longistatin, a Plasminogen Activator, Is Key to the Availability of Blood-Meals for Ixodid Ticks

Anisuzzaman, M. Khyrul Islam, M. Abdul Alim, Takeharu Miyoshi, Takeshi Hatta, Kayoko Yamaji, Yasunobu Matsumoto, Kozo Fujisaki, Naotoshi Tsuji

HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2

Karen E. Ocwieja, Troy L. Brady, Keshet Ronen, Alyssa Huegel, Shoshannah L. Roth, Torsten Schaller, Leo C. James, Greg J. Towers, John A. T. Young, Sumit K. Chanda, Renate König, Nirav Malani, Charles C. Berry, Frederic D. Bushman

The Danger Signal S100B Integrates Pathogen– and Danger–Sensing Pathways to Restrain Inflammation

Guglielmo Sorci, Gloria Giovannini, Francesca Riuzzi, Pierluigi Bonifazi, Teresa Zelante, Silvia Zagarella, Francesco Bistoni, Rosario Donato, Luigina Romani

KIR Polymorphisms Modulate Peptide-Dependent Binding to an MHC Class I Ligand with a Bw6 Motif

Arnaud D. Colantonio, Benjamin N. Bimber, William J. Neidermyer Jr, R. Keith Reeves, Galit Alter, Marcus Altfeld, R. Paul Johnson, Mary Carrington, David H. O'Connor, David T. Evans

The Moving Junction Protein RON8 Facilitates Firm Attachment and Host Cell Invasion in Toxoplasma gondii

Kurtis W. Straub, Eric D. Peng, Bettina E. Hajagos, Jessica S. Tyler, Peter J. Bradley

Antigenic Variation in Plasmodium falciparum Malaria Involves a Highly Structured Switching Pattern

Mario Recker, Caroline O. Buckee, Andrew Serazin, Sue Kyes, Robert Pinches, Zóe Christodoulou, Amy L. Springer, Sunetra Gupta, Chris I. Newbold

Spatial Distribution and Risk Factors of Highly Pathogenic Avian Influenza (HPAI) H5N1 in China

Vincent Martin, Dirk U. Pfeiffer, Xiaoyan Zhou, Xiangming Xiao, Diann J. Prosser, Fusheng Guo, Marius Gilbert

Sex and Death: The Effects of Innate Immune Factors on the Sexual Reproduction of Malaria Parasites

Ricardo S. Ramiro, João Alpedrinha, Lucy Carter, Andy Gardner, Sarah E. Reece

Global Functional Analyses of Cellular Responses to Pore-Forming Toxins

Cheng-Yuan Kao, Ferdinand C. O. Los, Danielle L. Huffman, Shinichiro Wachi, Nicole Kloft, Matthias Husmann, Valbona Karabrahimi, Jean-Louis Schwartz, Audrey Bellier, Christine Ha, Youn Sagong, Hui Fan, Partho Ghosh, Mindy Hsieh, Chih-Shen Hsu, Li Chen, Raffi V. Aroian

Invasive Extravillous Trophoblasts Restrict Intracellular Growth and Spread of Listeria monocytogenes

Varvara B. Zeldovich, Jennifer R. Robbins, Mirhan Kapidzic, Peter Lauer, Anna I. Bakardjiev