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Table of Contents: June 2012

COVER

Newly forming HIV virions embedded in the leading edge of dynamic filopodia.

Image Credit: Anupriya Aggarwal and Stuart Turville, Kirby Institute, University of New South Wales
Issue Image

HIV infection of dendritic cells and other cells of myeloid lineage provides a potent reservoir from which HIV can later seed CD4 T cells. In dissecting the mechanisms of viral transfer from HIV-infected dendritic cells to CD4 T cells, a dynamic structure consisting of newly formed HIV virions being launched by probing filopodia was observed (see Aggarwal et al., doi:10.1371/journal.ppat.1002762). HIV incorporation into the tips of dendritic cell filopodia is observed in the image, with HIV particles in white and filopodial networks in red visualised by F-actin staining. Nuclear staining by DAPI is presented in blue.

Opinion

Protecting against Pneumococcal Disease: Critical Interactions between Probiotics and the Airway Microbiome

Paul V. Licciardi, Zheng Quan Toh, Eileen Dunne, Sook-San Wong, Edward K. Mulholland, Mimi Tang, Roy M. Robins-Browne, Catherine Satzke

Pearls

Review

Manipulation of Costimulatory Molecules by Intracellular Pathogens: Veni, Vidi, Vici!!

Nargis Khan, Uthaman Gowthaman, Susanta Pahari, Javed N. Agrewala

Research Articles

The Calcitonin Receptor Gene Is a Candidate for Regulation of Susceptibility to Herpes simplex Type 1 Neuronal Infection Leading to Encephalitis in Rat

Nada Abdelmagid, Biborka Bereczky-Veress, André Ortlieb Guerreiro-Cacais, Petra Bergman, Katarina M. Luhr, Tomas Bergström, Birgit Sköldenberg, Fredrik Piehl, Tomas Olsson, Margarita Diez

Large Scale Genotype Comparison of Human Papillomavirus E2-Host Interaction Networks Provides New Insights for E2 Molecular Functions

Mandy Muller, Yves Jacob, Louis Jones, Amélie Weiss, Laurent Brino, Thibault Chantier, Vincent Lotteau, Michel Favre, Caroline Demeret

Broad Spectrum Pro-Quorum-Sensing Molecules as Inhibitors of Virulence in Vibrios

Wai-Leung Ng, Lark Perez, Jianping Cong, Martin F. Semmelhack, Bonnie L. Bassler

GogB Is an Anti-Inflammatory Effector that Limits Tissue Damage during Salmonella Infection through Interaction with Human FBXO22 and Skp1

Ana Victoria C. Pilar, Sarah A. Reid-Yu, Colin A. Cooper, David T. Mulder, Brian K. Coombes

Candida albicans Scavenges Host Zinc via Pra1 during Endothelial Invasion

Francesco Citiulo, Ilse D. Jacobsen, Pedro Miramón, Lydia Schild, Sascha Brunke, Peter Zipfel, Matthias Brock, Bernhard Hube, Duncan Wilson

Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity

Chia-Yi Yu, Tsung-Hsien Chang, Jian-Jong Liang, Ruei-Lin Chiang, Yi-Ling Lee, Ching-Len Liao, Yi-Ling Lin

The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response

Wendy Niedelman, Daniel A. Gold, Emily E. Rosowski, Joris K. Sprokholt, Daniel Lim, Ailan Farid Arenas, Mariane B. Melo, Eric Spooner, Michael B. Yaffe, Jeroen P. J. Saeij

Structural and Functional Insights into the Malaria Parasite Moving Junction Complex

Brigitte Vulliez-Le Normand, Michelle L. Tonkin, Mauld H. Lamarque, Susann Langer, Sylviane Hoos, Magali Roques, Frederick A. Saul, Bart W. Faber, Graham A. Bentley, Martin J. Boulanger, Maryse Lebrun

Polyfunctional Type-1, -2, and -17 CD8+ T Cell Responses to Apoptotic Self-Antigens Correlate with the Chronic Evolution of Hepatitis C Virus Infection

Debora Franceschini, Paola Del Porto, Silvia Piconese, Emanuele Trella, Daniele Accapezzato, Marino Paroli, Stefania Morrone, Enza Piccolella, Enea Spada, Alfonso Mele, John Sidney, Alessandro Sette, Vincenzo Barnaba

A Highly Intensified ART Regimen Induces Long-Term Viral Suppression and Restriction of the Viral Reservoir in a Simian AIDS Model

Iart Luca Shytaj, Sandro Norelli, Barbara Chirullo, Alessandro Della Corte, Matt Collins, Jake Yalley-Ogunro, Jack Greenhouse, Nunzio Iraci, Edward P. Acosta, Maria Letizia Barreca, Mark G. Lewis, Andrea Savarino

Multilocus Sequence Typing as a Replacement for Serotyping in Salmonella enterica

Mark Achtman, John Wain, François-Xavier Weill, Satheesh Nair, Zhemin Zhou, Vartul Sangal, Mary G. Krauland, James L. Hale, Heather Harbottle, Alexandra Uesbeck, Gordon Dougan, Lee H. Harrison, Sylvain Brisse , the S. enterica MLST study group

Highly Efficient Prion Transmission by Blood Transfusion

Olivier Andréoletti, Claire Litaise, Hugh Simmons, Fabien Corbière, Séverine Lugan, Pierrette Costes, François Schelcher, Didier Vilette, Jacques Grassi, Caroline Lacroux

Molecular Inferences Suggest Multiple Host Shifts of Rabies Viruses from Bats to Mesocarnivores in Arizona during 2001–2009

Ivan V. Kuzmin, Mang Shi, Lillian A. Orciari, Pamela A. Yager, Andres Velasco-Villa, Natalia A. Kuzmina, Daniel G. Streicker, David L. Bergman, Charles E. Rupprecht

Human Breast Milk and Antiretrovirals Dramatically Reduce Oral HIV-1 Transmission in BLT Humanized Mice

Angela Wahl, Michael D. Swanson, Tomonori Nochi, Rikke Olesen, Paul W. Denton, Morgan Chateau, J. Victor Garcia

Synergistic Parasite-Pathogen Interactions Mediated by Host Immunity Can Drive the Collapse of Honeybee Colonies

Francesco Nazzi, Sam P. Brown, Desiderato Annoscia, Fabio Del Piccolo, Gennaro Di Prisco, Paola Varricchio, Giorgio Della Vedova, Federica Cattonaro, Emilio Caprio, Francesco Pennacchio

DNase Sda1 Allows Invasive M1T1 Group A Streptococcus to Prevent TLR9-Dependent Recognition

Satoshi Uchiyama, Federica Andreoni, Reto A. Schuepbach, Victor Nizet, Annelies S. Zinkernagel

The Salmonella Deubiquitinase SseL Inhibits Selective Autophagy of Cytosolic Aggregates

Francisco S. Mesquita, Mair Thomas, Martin Sachse, António J. M. Santos, Rita Figueira, David W. Holden

A High-Resolution View of Genome-Wide Pneumococcal Transformation

Nicholas J. Croucher, Simon R. Harris, Lars Barquist, Julian Parkhill, Stephen D. Bentley

Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB

Hua Xiang, Yue Feng, Jiawei Wang, Bao Liu, Yeguang Chen, Lei Liu, Xuming Deng, Maojun Yang

African Swine Fever Virus Uses Macropinocytosis to Enter Host Cells

Elena G. Sánchez, Ana Quintas, Daniel Pérez-Núñez, Marisa Nogal, Susana Barroso, Ángel L. Carrascosa, Yolanda Revilla

Role of the Group B Antigen of Streptococcus agalactiae: A Peptidoglycan-Anchored Polysaccharide Involved in Cell Wall Biogenesis

Élise Caliot, Shaynoor Dramsi, Marie-Pierre Chapot-Chartier, Pascal Courtin, Saulius Kulakauskas, Christine Péchoux, Patrick Trieu-Cuot, Michel-Yves Mistou

The YfiBNR Signal Transduction Mechanism Reveals Novel Targets for the Evolution of Persistent Pseudomonas aeruginosa in Cystic Fibrosis Airways

Jacob G. Malone, Tina Jaeger, Pablo Manfredi, Andreas Dötsch, Andrea Blanka, Raphael Bos, Guy R. Cornelis, Susanne Häussler, Urs Jenal

Conditional Stat1 Ablation Reveals the Importance of Interferon Signaling for Immunity to Listeria monocytogenes Infection

Elisabeth Kernbauer, Verena Maier, Dagmar Stoiber, Birgit Strobl, Christine Schneckenleithner, Veronika Sexl, Ursula Reichart, Boris Reizis, Ulrich Kalinke, Amanda Jamieson, Mathias Müller, Thomas Decker

The Interdomain Linker of AAV-2 Rep68 Is an Integral Part of Its Oligomerization Domain: Role of a Conserved SF3 Helicase Residue in Oligomerization

Francisco Zarate-Perez, Martino Bardelli, John W. Burgner II, Maria Villamil-Jarauta, Kanni Das, Demet Kekilli, Jorge Mansilla-Soto, R. Michael Linden, Carlos R. Escalante

Tomato TFT1 Is Required for PAMP-Triggered Immunity and Mutations that Prevent T3S Effector XopN from Binding to TFT1 Attenuate Xanthomonas Virulence

Kyle W. Taylor, Jung-Gun Kim, Xue B. Su, Chris D. Aakre, Julie A. Roden, Christopher M. Adams, Mary Beth Mudgett

Opposing Regulation of PROX1 by Interleukin-3 Receptor and NOTCH Directs Differential Host Cell Fate Reprogramming by Kaposi Sarcoma Herpes Virus

Jaehyuk Yoo, Ha Neul Lee, Inho Choi, Dongwon Choi, Hee Kyoung Chung, Kyu Eui Kim, Sunju Lee, Berenice Aguilar, Jinjoo Kang, Eunkyung Park, Yong Suk Lee, Yong-Sun Maeng, Nam Yoon Kim, Chester J. Koh, Young-Kwon Hong

Evidence for Induction of Integron-Based Antibiotic Resistance by the SOS Response in a Clinical Setting

Didier Hocquet, Catherine Llanes, Michelle Thouverez, Hemantha D. Kulasekara, Xavier Bertrand, Patrick Plésiat, Didier Mazel, Samuel I. Miller

Cytomegalovirus Replicon-Based Regulation of Gene Expression In Vitro and In Vivo

Hermine Mohr, Christian A. Mohr, Marlon R. Schneider, Laura Scrivano, Barbara Adler, Simone Kraner-Schreiber, Angelika Schnieke, Maik Dahlhoff, Eckhard Wolf, Ulrich H. Koszinowski, Zsolt Ruzsics

Evolution of Salmonella enterica Virulence via Point Mutations in the Fimbrial Adhesin

Dagmara I. Kisiela, Sujay Chattopadhyay, Stephen J. Libby, Joyce E. Karlinsey, Ferric C. Fang, Veronika Tchesnokova, Jeremy J. Kramer, Viktoriya Beskhlebnaya, Mansour Samadpour, Krzysztof Grzymajlo, Maciej Ugorski, Emily W. Lankau, Roderick I. Mackie, Steven Clegg, Evgeni V. Sokurenko

Anopheles Imd Pathway Factors and Effectors in Infection Intensity-Dependent Anti-Plasmodium Action

Lindsey S. Garver, Ana C. Bahia, Suchismita Das, Jayme A. Souza-Neto, Jessica Shiao, Yuemei Dong, George Dimopoulos

Functional Amyloids Composed of Phenol Soluble Modulins Stabilize Staphylococcus aureus Biofilms

Kelly Schwartz, Adnan K. Syed, Rachel E. Stephenson, Alexander H. Rickard, Blaise R. Boles

Propagation of RML Prions in Mice Expressing PrP Devoid of GPI Anchor Leads to Formation of a Novel, Stable Prion Strain

Sukhvir Paul Mahal, Joseph Jablonski, Irena Suponitsky-Kroyter, Anja Maria Oelschlegel, Maria Eugenia Herva, Michael Oldstone, Charles Weissmann

Circulating Microbial Products and Acute Phase Proteins as Markers of Pathogenesis in Lymphatic Filarial Disease

R. Anuradha, P. Jovvian George, N. Pavan Kumar, Michael P. Fay, V. Kumaraswami, Thomas B. Nutman, Subash Babu

Structure-Function Analysis of Barley NLR Immune Receptor MLA10 Reveals Its Cell Compartment Specific Activity in Cell Death and Disease Resistance

Shiwei Bai, Jie Liu, Cheng Chang, Ling Zhang, Takaki Maekawa, Qiuyun Wang, Wenkai Xiao, Yule Liu, Jijie Chai, Frank L. W. Takken, Paul Schulze-Lefert, Qian-Hua Shen

Identification of a General O-linked Protein Glycosylation System in Acinetobacter baumannii and Its Role in Virulence and Biofilm Formation

Jeremy A. Iwashkiw, Andrea Seper, Brent S. Weber, Nichollas E. Scott, Evgeny Vinogradov, Chad Stratilo, Bela Reiz, Stuart J. Cordwell, Randy Whittal, Stefan Schild, Mario F. Feldman

Mobilization of HIV Spread by Diaphanous 2 Dependent Filopodia in Infected Dendritic Cells

Anupriya Aggarwal, Tina L. Iemma, Ivy Shih, Timothy P. Newsome, Samantha McAllery, Anthony L. Cunningham, Stuart G. Turville