Advertisement

Table of Contents: August 2012

COVER

Macrophages in a liver granuloma around Schistosoma mansoni eggs.

Image Credit: Natasha M. Girgis, New York University Langone Medical Center.
Issue Image

Alternatively activated macrophages regulate immune responses in the granulomas around S. mansoni eggs. These cells are an important source of retinoic acid and enhance the differentiation of Foxp3+ T cell differentiation (see Broadhurst et al., doi:10.1371/journal.ppat.1002883). By intravital confocal imaging, autofluorescent eggs are observed in red, hepatocyte nuclei in blue, and CX3CR1+ macrophages in green.

Viewpoints

Nonhuman Primate Models for HIV Cure Research

Cristian Apetrei, Ivona Pandrea, John W. Mellors

Opinion

Routine Use of Microbial Whole Genome Sequencing in Diagnostic and Public Health Microbiology

Claudio U. Köser, Matthew J. Ellington, Edward J. P. Cartwright, Stephen H. Gillespie, Nicholas M. Brown, Mark Farrington, Matthew T. G. Holden, Gordon Dougan, Stephen D. Bentley, Julian Parkhill, Sharon J. Peacock

Pearls

Bacterial Cell Surface Heterogeneity: A Pathogen's Disguise

Henny C. van der Mei, Henk J. Busscher

Trichomonosis, a Common Curable STI, and Prostate Carcinogenesis—A Proposed Molecular Mechanism

Siobhan Sutcliffe, Calvin Neace, Nancy S. Magnuson, Raymond Reeves, J. F. Alderete

Host Defense and Tolerance: Unique Challenges in the Placenta

Varvara B. Zeldovich, Anna I. Bakardjiev

Phagocyte Responses to Protozoan Infection and How Toxoplasma gondii Meets the Challenge

Eric Y. Denkers, Anne G. Schneider, Sara B. Cohen, Barbara A. Butcher

Review

Invariant NKT Cells: Regulation and Function during Viral Infection

Jennifer A. Juno, Yoav Keynan, Keith R. Fowke

Research Articles

Inhibition of Candida parapsilosis Fatty Acid Synthase (Fas2) Induces Mitochondrial Cell Death in Serum

Long Nam Nguyen, Gabriele Vargas Cesar, Giang Thi Thu Le, David L. Silver, Leonardo Nimrichter, Joshua D. Nosanchuk

Measles Immune Suppression: Lessons from the Macaque Model

Rory D. de Vries, Stephen McQuaid, Geert van Amerongen, Selma Yüksel, R. Joyce Verburgh, Albert D. M. E. Osterhaus, W. Paul Duprex, Rik L. de Swart

Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees

Trevor J. Morin, Teresa J. Broering, Brett A. Leav, Barbra M. Blair, Kirk J. Rowley, Elisabeth N. Boucher, Yang Wang, Peter S. Cheslock, Michael Knauber, David B. Olsen, Steve W. Ludmerer, Gyongyi Szabo, Robert W. Finberg, Robert H. Purcell, Robert E. Lanford, Donna M. Ambrosino, Deborah C. Molrine, Gregory J. Babcock

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

Amanda J. Price, Adam J. Fletcher, Torsten Schaller, Tom Elliott, KyeongEun Lee, Vineet N. KewalRamani, Jason W. Chin, Greg J. Towers, Leo C. James

Roles of ATM and ATR-Mediated DNA Damage Responses during Lytic BK Polyomavirus Infection

Mengxi Jiang, Linbo Zhao, Monica Gamez, Michael J. Imperiale

Establishment of a Reverse Genetics System for Studying Human Bocavirus in Human Airway Epithelia

Qinfeng Huang, Xuefeng Deng, Ziying Yan, Fang Cheng, Yong Luo, Weiran Shen, Diana C. M. Lei-Butters, Aaron Yun Chen, Yi Li, Liang Tang, Maria Söderlund-Venermo, John F. Engelhardt, Jianming Qiu

Telomere Length Affects the Frequency and Mechanism of Antigenic Variation in Trypanosoma brucei

Galadriel A. Hovel-Miner, Catharine E. Boothroyd, Monica Mugnier, Oliver Dreesen, George A. M. Cross, F. Nina Papavasiliou

Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection

Sara Rodríguez-Martín, Kai Alexander Kropp, Vanessa Wilhelmi, Vanda Juranic Lisnic, Wei Yuan Hsieh, Mathieu Blanc, Andrew Livingston, Andreas Busche, Hille Tekotte, Martin Messerle, Manfred Auer, Iain Fraser, Stipan Jonjic, Ana Angulo, Matthias J. Reddehase, Peter Ghazal

A Novel Virulence Strategy for Pseudomonas aeruginosa Mediated by an Autotransporter with Arginine-Specific Aminopeptidase Activity

Jeni C. A. Luckett, Owen Darch, Chase Watters, Manal AbuOun, Victoria Wright, Esteban Paredes-Osses, Jenny Ward, Hana Goto, Stephan Heeb, Stéphanie Pommier, Kendra P. Rumbaugh, Miguel Cámara, Kim R. Hardie

The Irish Potato Famine Pathogen Phytophthora infestans Translocates the CRN8 Kinase into Host Plant Cells

Mireille van Damme, Tolga O. Bozkurt, Cahid Cakir, Sebastian Schornack, Jan Sklenar, Alexandra M. E. Jones, Sophien Kamoun

Elucidation of Hepatitis C Virus Transmission and Early Diversification by Single Genome Sequencing

Hui Li, Mark B. Stoddard, Shuyi Wang, Lily M. Blair, Elena E. Giorgi, Erica H. Parrish, Gerald H. Learn, Peter Hraber, Paul A. Goepfert, Michael S. Saag, Thomas N. Denny, Barton F. Haynes, Beatrice H. Hahn, Ruy M. Ribeiro, Alan S. Perelson, Bette T. Korber, Tanmoy Bhattacharya, George M. Shaw

Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation Rate

Ruy M. Ribeiro, Hui Li, Shuyi Wang, Mark B. Stoddard, Gerald H. Learn, Bette T. Korber, Tanmoy Bhattacharya, Jeremie Guedj, Erica H. Parrish, Beatrice H. Hahn, George M. Shaw, Alan S. Perelson

Surface α-1,3-Glucan Facilitates Fungal Stealth Infection by Interfering with Innate Immunity in Plants

Takashi Fujikawa, Ayumu Sakaguchi, Yoko Nishizawa, Yusuke Kouzai, Eiichi Minami, Shigekazu Yano, Hironori Koga, Tetsuo Meshi, Marie Nishimura

Upregulation of Retinal Dehydrogenase 2 in Alternatively Activated Macrophages during Retinoid-dependent Type-2 Immunity to Helminth Infection in Mice

Mara J. Broadhurst, Jacqueline M. Leung, K. C. Lim, Natasha M. Girgis, Uma Mahesh Gundra, Padraic G. Fallon, Mary Premenko-Lanier, James H. McKerrow, Joseph M. McCune, P'ng Loke

Ago HITS-CLIP Expands Understanding of Kaposi's Sarcoma-associated Herpesvirus miRNA Function in Primary Effusion Lymphomas

Irina Haecker, Lauren A. Gay, Yajie Yang, Jianhong Hu, Alison M. Morse, Lauren M. McIntyre, Rolf Renne

Protease Cleavage Leads to Formation of Mature Trimer Interface in HIV-1 Capsid

Xin Meng, Gongpu Zhao, Ernest Yufenyuy, Danxia Ke, Jiying Ning, Maria DeLucia, Jinwoo Ahn, Angela M. Gronenborn, Christopher Aiken, Peijun Zhang

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge

Michael D. Alpert, Jackson D. Harvey, W. Anderson Lauer, R. Keith Reeves, Michael Piatak Jr., Angela Carville, Keith G. Mansfield, Jeffrey D. Lifson, Wenjun Li, Ronald C. Desrosiers, R. Paul Johnson, David T. Evans

CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction

Yoav Peretz, Zhong He, Yu Shi, Bader Yassine-Diab, Jean-Philippe Goulet, Rebeka Bordi, Ali Filali-Mouhim, Jean-Baptiste Loubert, Mohamed El-Far, Franck P. Dupuy, Mohamed Rachid Boulassel, Cécile Tremblay, Jean-Pierre Routy, Nicole Bernard, Robert Balderas, Elias K. Haddad, Rafick-Pierre Sékaly

Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation

Sophia Maschalidi, Signe Hässler, Fany Blanc, Fernando E. Sepulveda, Mira Tohme, Michel Chignard, Peter van Endert, Mustapha Si-Tahar, Delphyne Descamps, Bénédicte Manoury

Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell Pool Changes Observed in Mice with Aging

Luka Cicin-Sain, James D. Brien, Jennifer L. Uhrlaub, Anja Drabig, Thomas F. Marandu, Janko Nikolich-Zugich

Immune Senescence: Relative Contributions of Age and Cytomegalovirus Infection

Andrea Mekker, Vincent S. Tchang, Lea Haeberli, Annette Oxenius, Alexandra Trkola, Urs Karrer

Self-Enhancement of Hepatitis C Virus Replication by Promotion of Specific Sphingolipid Biosynthesis

Yuichi Hirata, Kazutaka Ikeda, Masayuki Sudoh, Yuko Tokunaga, Akemi Suzuki, Leiyun Weng, Masatoshi Ohta, Yoshimi Tobita, Ken Okano, Kazuhisa Ozeki, Kenichi Kawasaki, Takuo Tsukuda, Asao Katsume, Yuko Aoki, Takuya Umehara, Satoshi Sekiguchi, Tetsuya Toyoda, Kunitada Shimotohno, Tomoyoshi Soga, Masahiro Nishijima, Ryo Taguchi, Michinori Kohara

Functional Genomic Analysis of Candida glabrata-Macrophage Interaction: Role of Chromatin Remodeling in Virulence

Maruti Nandan Rai, Sriram Balusu, Neelima Gorityala, Lakshmi Dandu, Rupinder Kaur

Chemokine Receptor Ccr1 Drives Neutrophil-Mediated Kidney Immunopathology and Mortality in Invasive Candidiasis

Michail S. Lionakis, Brett G. Fischer, Jean K. Lim, Muthulekha Swamydas, Wuzhou Wan, Chyi-Chia Richard Lee, Jeffrey I. Cohen, Phillip Scheinberg, Ji-Liang Gao, Philip M. Murphy

Convergent Evolution of Argonaute-2 Slicer Antagonism in Two Distinct Insect RNA Viruses

Joël T. van Mierlo, Alfred W. Bronkhorst, Gijs J. Overheul, Sajna A. Sadanandan, Jens-Ola Ekström, Marco Heestermans, Dan Hultmark, Christophe Antoniewski, Ronald P. van Rij

IFNγ Inhibits the Cytosolic Replication of Shigella flexneri via the Cytoplasmic RNA Sensor RIG-I

Stephanie P. Jehl, Catarina V. Nogueira, Xuqing Zhang, Michael N. Starnbach

HSV-1 Genome Subnuclear Positioning and Associations with Host-Cell PML-NBs and Centromeres Regulate LAT Locus Transcription during Latency in Neurons

Frédéric Catez, Christel Picard, Kathrin Held, Sylvain Gross, Antoine Rousseau, Diethilde Theil, Nancy Sawtell, Marc Labetoulle, Patrick Lomonte

Surface Proteome Analysis and Characterization of Surface Cell Antigen (Sca) or Autotransporter Family of Rickettsia typhi

Khandra T. Sears, Shane M. Ceraul, Joseph J. Gillespie, Edwin D. Allen Jr., Vsevolod L. Popov, Nicole C. Ammerman, M. Sayeedur Rahman, Abdu F. Azad

The HSV-1 Exonuclease, UL12, Stimulates Recombination by a Single Strand Annealing Mechanism

April J. Schumacher, Kareem N. Mohni, Yinan Kan, Eric A. Hendrickson, Jeremy M. Stark, Sandra K. Weller

Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes

Tracy O'Connor, Nathalie Frei, Jana Sponarova, Petra Schwarz, Mathias Heikenwalder, Adriano Aguzzi

Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral Infection

Kathrin Gibbert, Jara J. Joedicke, Andreas Meryk, Mirko Trilling, Sandra Francois, Janine Duppach, Anke Kraft, Karl S. Lang, Ulf Dittmer

Identification of MrtAB, an ABC Transporter Specifically Required for Yersinia pseudotuberculosis to Colonize the Mesenteric Lymph Nodes

Gregory T. Crimmins, Sina Mohammadi, Erin R. Green, Molly A. Bergman, Ralph R. Isberg, Joan Mecsas

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

Rebecca M. DuBois, P. Jake Slavish, Brandi M. Baughman, Mi-Kyung Yun, Ju Bao, Richard J. Webby, Thomas R. Webb, Stephen W. White

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

Eva Kowalinski, Chloe Zubieta, Andrea Wolkerstorfer, Oliver H. J. Szolar, Rob W. H. Ruigrok, Stephen Cusack

AsrR Is an Oxidative Stress Sensing Regulator Modulating Enterococcus faecium Opportunistic Traits, Antimicrobial Resistance, and Pathogenicity

François Lebreton, Willem van Schaik, Maurizio Sanguinetti, Brunella Posteraro, Riccardo Torelli, Florian Le Bras, Nicolas Verneuil, Xinglin Zhang, Jean-Christophe Giard, Anne Dhalluin, Rob J. L. Willems, Roland Leclercq, Vincent Cattoir

Small Protease Sensitive Oligomers of PrPSc in Distinct Human Prions Determine Conversion Rate of PrPC

Chae Kim, Tracy Haldiman, Krystyna Surewicz, Yvonne Cohen, Wei Chen, Janis Blevins, Man-Sun Sy, Mark Cohen, Qingzhong Kong, Glenn C. Telling, Witold K. Surewicz, Jiri G. Safar

Cedar Virus: A Novel Henipavirus Isolated from Australian Bats

Glenn A. Marsh, Carol de Jong, Jennifer A. Barr, Mary Tachedjian, Craig Smith, Deborah Middleton, Meng Yu, Shawn Todd, Adam J. Foord, Volker Haring, Jean Payne, Rachel Robinson, Ivano Broz, Gary Crameri, Hume E. Field, Lin-Fa Wang

Natural Transformation Facilitates Transfer of Transposons, Integrons and Gene Cassettes between Bacterial Species

Sara Domingues, Klaus Harms, W. Florian Fricke, Pål J. Johnsen, Gabriela J. da Silva, Kaare Magne Nielsen

Uridine Composition of the Poly-U/UC Tract of HCV RNA Defines Non-Self Recognition by RIG-I

Gretja Schnell, Yueh-Ming Loo, Joseph Marcotrigiano, Michael Gale Jr.

CPAF: A Chlamydial Protease in Search of an Authentic Substrate

Allan L. Chen, Kirsten A. Johnson, Jennifer K. Lee, Christine Sütterlin, Ming Tan

Bap, a Biofilm Matrix Protein of Staphylococcus aureus Prevents Cellular Internalization through Binding to GP96 Host Receptor

Jaione Valle, Cristina Latasa, Carmen Gil, Alejandro Toledo-Arana, Cristina Solano, José R. Penadés, Iñigo Lasa

High Virulence of Wolbachia after Host Switching: When Autophagy Hurts

Winka Le Clec'h, Christine Braquart-Varnier, Maryline Raimond, Jean-Baptiste Ferdy, Didier Bouchon, Mathieu Sicard

IL-10 Suppression of NK/DC Crosstalk Leads to Poor Priming of MCMV-Specific CD4 T Cells and Prolonged MCMV Persistence

Sanja Mandaric, Senta M. Walton, Thomas Rülicke, Kirsten Richter, Mathilde J. H. Girard-Madoux, Björn E. Clausen, Antonija Zurunic, Masahito Kamanaka, Richard A. Flavell, Stipan Jonjic, Annette Oxenius

The Ebola Virus Glycoprotein Contributes to but Is Not Sufficient for Virulence In Vivo

Allison Groseth, Andrea Marzi, Thomas Hoenen, Astrid Herwig, Don Gardner, Stephan Becker, Hideki Ebihara, Heinz Feldmann

A Candida Biofilm-Induced Pathway for Matrix Glucan Delivery: Implications for Drug Resistance

Heather T. Taff, Jeniel E. Nett, Robert Zarnowski, Kelly M. Ross, Hiram Sanchez, Mike T. Cain, Jessica Hamaker, Aaron P. Mitchell, David R. Andes

Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

Juan Reguera, César Santiago, Gaurav Mudgal, Desiderio Ordoño, Luis Enjuanes, José M. Casasnovas