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Table of Contents: March 2013

COVER

Co-localization of DENV NS5 with UBR4

Image Credit: Giuseppe Pisanelli, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Issue Image

Dengue virus (DENV) NS5 protein inhibits type I interferon signaling by mediating the proteasomal degradation of STAT2, which results in enhanced viral replication and dissemination in the host. Morrison et al. show that DENV NS5 protein interacts with UBR4, a member of a family of predicted E3 ligases. This interaction is critical for DENV NS5-mediated STAT2 degradation, and consequently for DENV replication, in the presence of a competent type I interferon system. This picture shows the co-localization of DENV NS5 with UBR4.

Opinion

Pearls

Reviews

The KdpD/KdpE Two-Component System: Integrating K+ Homeostasis and Virulence

Zoë N. Freeman, Steve Dorus, Nicholas R. Waterfield

Research Articles

HSV-2 Specifically Down Regulates HLA-C Expression to Render HSV-2-Infected DCs Susceptible to NK Cell Killing

Moran Elboim, Inna Grodzovski, Esther Djian, Dana G. Wolf, Ofer Mandelboim

Productive Homologous and Non-homologous Recombination of Hepatitis C Virus in Cell Culture

Troels K. H. Scheel, Andrea Galli, Yi-Ping Li, Lotte S. Mikkelsen, Judith M. Gottwein, Jens Bukh

TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine

Stephanie Jemielity, Jinyize J. Wang, Ying Kai Chan, Asim A. Ahmed, Wenhui Li, Sheena Monahan, Xia Bu, Michael Farzan, Gordon J. Freeman, Dale T. Umetsu, Rosemarie H. DeKruyff, Hyeryun Choe

Prophage Induction Is Enhanced and Required for Renal Disease and Lethality in an EHEC Mouse Model

Jessica S. Tyler, Karen Beeri, Jared L. Reynolds, Christopher J. Alteri, Katherine G. Skinner, Jonathan H. Friedman, Kathryn A. Eaton, David I. Friedman

Digoxin Suppresses HIV-1 Replication by Altering Viral RNA Processing

Raymond W. Wong, Ahalya Balachandran, Mario A. Ostrowski, Alan Cochrane

HIV Restriction by APOBEC3 in Humanized Mice

John F. Krisko, Francisco Martinez-Torres, John L. Foster, J. Victor Garcia

Two-Component Signal Transduction System CBO0787/CBO0786 Represses Transcription from Botulinum Neurotoxin Promoters in Clostridium botulinum ATCC 3502

Zhen Zhang, Hannu Korkeala, Elias Dahlsten, Elina Sahala, John T. Heap, Nigel P. Minton, Miia Lindström

Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling

Juliet Morrison, Maudry Laurent-Rolle, Ana M. Maestre, Ricardo Rajsbaum, Giuseppe Pisanelli, Viviana Simon, Lubbertus C. F. Mulder, Ana Fernandez-Sesma, Adolfo García-Sastre

Hantavirus-infection Confers Resistance to Cytotoxic Lymphocyte-Mediated Apoptosis

Shawon Gupta, Monika Braun, Nicole D. Tischler, Malin Stoltz, Karin B. Sundström, Niklas K. Björkström, Hans-Gustaf Ljunggren, Jonas Klingström

A Ubiquitin-specific Protease Possesses a Decisive Role for Adenovirus Replication and Oncogene-mediated Transformation

Wilhelm Ching, Emre Koyuncu, Sonia Singh, Christina Arbelo-Roman, Barbara Hartl, Elisabeth Kremmer, Thomas Speiseder, Chris Meier, Thomas Dobner

Experimental Human Pneumococcal Carriage Augments IL-17A-dependent T-cell Defence of the Lung

Adam K. A. Wright, Mathieu Bangert, Jenna F. Gritzfeld, Daniela M. Ferreira, Kondwani C. Jambo, Angela D. Wright, Andrea M. Collins, Stephen B. Gordon

Monomeric Nucleoprotein of Influenza A Virus

Sylvie Chenavas, Leandro F. Estrozi, Anny Slama-Schwok, Bernard Delmas, Carmelo Di Primo, Florence Baudin, Xinping Li, Thibaut Crépin, Rob W. H. Ruigrok

Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein

Benjamin Mänz, Dominik Dornfeld, Veronika Götz, Roland Zell, Petra Zimmermann, Otto Haller, Georg Kochs, Martin Schwemmle

Pseudomonas syringae pv. syringae Uses Proteasome Inhibitor Syringolin A to Colonize from Wound Infection Sites

Johana C. Misas-Villamil, Izabella Kolodziejek, Emerson Crabill, Farnusch Kaschani, Sherry Niessen, Takayuki Shindo, Markus Kaiser, James R. Alfano, Renier A. L. van der Hoorn

Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

Claudine Porta, Abhay Kotecha, Alison Burman, Terry Jackson, Jingshan Ren, Silvia Loureiro, Ian M. Jones, Elizabeth E. Fry, David I. Stuart, Bryan Charleston

Biomphalysin, a New β Pore-forming Toxin Involved in Biomphalaria glabrata Immune Defense against Schistosoma mansoni

Richard Galinier, Julien Portela, Yves Moné, Jean François Allienne, Hélène Henri, Stéphane Delbecq, Guillaume Mitta, Benjamin Gourbal, David Duval

Plasminogen Controls Inflammation and Pathogenesis of Influenza Virus Infections via Fibrinolysis

Fatma Berri, Guus F. Rimmelzwaan, Michel Hanss, Emmanuel Albina, Marie-Laure Foucault-Grunenwald, Vuong B. Lê, Stella E. Vogelzang-van Trierum, Patrica Gil, Eric Camerer, Dominique Martinez, Bruno Lina, Roger Lijnen, Peter Carmeliet, Béatrice Riteau

Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

Bei Wang, Xueyan Xi, Xiaobo Lei, Xiaoyan Zhang, Sheng Cui, Jianwei Wang, Qi Jin, Zhendong Zhao

Lymphotoxin Signaling Is Initiated by the Viral Polymerase in HCV-linked Tumorigenesis

Yannick Simonin, Serena Vegna, Leila Akkari, Damien Grégoire, Etienne Antoine, Jacques Piette, Nicolas Floc'h, Patrice Lassus, Guann-Yi Yu, Arielle R. Rosenberg, Michael Karin, David Durantel, Urszula Hibner

Kinetics of Coinfection with Influenza A Virus and Streptococcus pneumoniae

Amber M. Smith, Frederick R. Adler, Ruy M. Ribeiro, Ryan N. Gutenkunst, Julie L. McAuley, Jonathan A. McCullers, Alan S. Perelson

A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus

Jacquelyn Horsington, Helena Lynn, Lynne Turnbull, Delfine Cheng, Filip Braet, Russell J. Diefenbach, Cynthia B. Whitchurch, Guna Karupiah, Timothy P. Newsome

The Enterovirus 71 A-particle Forms a Gateway to Allow Genome Release: A CryoEM Study of Picornavirus Uncoating

Kristin L. Shingler, Jennifer L. Yoder, Michael S. Carnegie, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Susan Hafenstein

IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection

Claudia Gonzalez-Lombana, Ciara Gimblet, Olivia Bacellar, Walker W. Oliveira, Sara Passos, Lucas P. Carvalho, Michael Goldschmidt, Edgar M. Carvalho, Phillip Scott

Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies

Marion Sourisseau, Maria L. Michta, Chati Zony, Benjamin Israelow, Sharon E. Hopcraft, Christopher M. Narbus, Ana Parra Martín, Matthew J. Evans

The Common Structural Architecture of Shigella flexneri and Salmonella typhimurium Type Three Secretion Needles

Jean-Philippe Demers, Nikolaos G. Sgourakis, Rashmi Gupta, Antoine Loquet, Karin Giller, Dietmar Riedel, Britta Laube, Michael Kolbe, David Baker, Stefan Becker, Adam Lange

Dimeric RNA Recognition Regulates HIV-1 Genome Packaging

Olga A. Nikolaitchik, Kari A. Dilley, William Fu, Robert J. Gorelick, S.-H. Sheldon Tai, Ferri Soheilian, Roger G. Ptak, Kunio Nagashima, Vinay K. Pathak, Wei-Shau Hu

TIM-3 Does Not Act as a Receptor for Galectin-9

Judith Leitner, Armin Rieger, Winfried F. Pickl, Gerhard Zlabinger, Katharina Grabmeier-Pfistershammer, Peter Steinberger

Dendritic Cell-induced Activation of Latent HIV-1 Provirus in Actively Proliferating Primary T Lymphocytes

Renée M. van der Sluis, Thijs van Montfort, Georgios Pollakis, Rogier W. Sanders, Dave Speijer, Ben Berkhout, Rienk E. Jeeninga

Genome-wide Determinants of Proviral Targeting, Clonal Abundance and Expression in Natural HTLV-1 Infection

Anat Melamed, Daniel J. Laydon, Nicolas A. Gillet, Yuetsu Tanaka, Graham P. Taylor, Charles R. M. Bangham

Epstein - Barr Virus Transforming Protein LMP-1 Alters B Cells Gene Expression by Promoting Accumulation of the Oncoprotein ΔNp73α

Rosita Accardi, Ikbal Fathallah, Henri Gruffat, Giuseppe Mariggiò, Florence Le Calvez-Kelm, Catherine Voegele, Birke Bartosch, Hector Hernandez-Vargas, James McKay, Bakary S. Sylla, Evelyne Manet, Massimo Tommasino

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

Brian J. Laidlaw, Vilma Decman, Mohammed-Alkhatim A. Ali, Michael C. Abt, Amaya I. Wolf, Laurel A. Monticelli, Krystyna Mozdzanowska, Jill M. Angelosanto, David Artis, Jan Erikson, E. John Wherry

The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells

Anna Schurich, Laura J. Pallett, Marcin Lubowiecki, Harsimran D. Singh, Upkar S. Gill, Patrick T. Kennedy, Eleni Nastouli, Sudeep Tanwar, William Rosenberg, Mala K. Maini

Evolution of Virulence in Emerging Epidemics

Thomas W. Berngruber, Rémy Froissart, Marc Choisy, Sylvain Gandon

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

Asier Sáez-Cirión, Charline Bacchus, Laurent Hocqueloux, Véronique Avettand-Fenoel, Isabelle Girault, Camille Lecuroux, Valerie Potard, Pierre Versmisse, Adeline Melard, Thierry Prazuck, Benjamin Descours, Julien Guergnon, Jean-Paul Viard, Faroudy Boufassa, Olivier Lambotte, Cécile Goujard, Laurence Meyer, Dominique Costagliola, Alain Venet, Gianfranco Pancino, Brigitte Autran, Christine Rouzioux , the ANRS VISCONTI Study Group

Th2 Cell-Intrinsic Hypo-Responsiveness Determines Susceptibility to Helminth Infection

Nienke van der Werf, Stephen A. Redpath, Miyuki Azuma, Hideo Yagita, Matthew D. Taylor

Trichoderma-Plant Root Colonization: Escaping Early Plant Defense Responses and Activation of the Antioxidant Machinery for Saline Stress Tolerance

Yariv Brotman, Udi Landau, Álvaro Cuadros-Inostroza, Tohge Takayuki, Alisdair R. Fernie, Ilan Chet, Ada Viterbo, Lothar Willmitzer

Glycomic Analysis of Human Respiratory Tract Tissues and Correlation with Influenza Virus Infection

Trevenan Walther, Rositsa Karamanska, Renee W. Y. Chan, Michael C. W. Chan, Nan Jia, Gillian Air, Clark Hopton, Maria P. Wong, Anne Dell, J. S. Malik Peiris, Stuart M. Haslam, John M. Nicholls

Three-dimensional Structure of Victorivirus HvV190S Suggests Coat Proteins in Most Totiviruses Share a Conserved Core

Sarah E. Dunn, Hua Li, Giovanni Cardone, Max L. Nibert, Said A. Ghabrial, Timothy S. Baker

Novel Positive Regulatory Role for the SPL6 Transcription Factor in the N TIR-NB-LRR Receptor-Mediated Plant Innate Immunity

Meenu S. Padmanabhan, Shisong Ma, Tessa M. Burch-Smith, Kirk Czymmek, Peter Huijser, Savithramma P. Dinesh-Kumar

Nosema ceranae Escapes Fumagillin Control in Honey Bees

Wei-Fone Huang, Leellen F. Solter, Peter M. Yau, Brian S. Imai

Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates

James D. Tamerius, Jeffrey Shaman, Wladmir J. Alonso, Kimberly Bloom-Feshbach, Christopher K. Uejio, Andrew Comrie, Cécile Viboud

Glucocortiocoid Treatment of MCMV Infected Newborn Mice Attenuates CNS Inflammation and Limits Deficits in Cerebellar Development

Kate Kosmac, Glenn R. Bantug, Ester P. Pugel, Djurdjica Cekinovic, Stipan Jonjic, William J. Britt

A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition

David Lutje Hulsik, Ying-ying Liu, Nika M. Strokappe, Simone Battella, Mohamed El Khattabi, Laura E. McCoy, Charles Sabin, Andreas Hinz, Miriam Hock, Pauline Macheboeuf, Alexandre M. J. J. Bonvin, Johannes P. M. Langedijk, David Davis, Anna Forsman Quigley, Marlén M. I. Aasa-Chapman, Michael S. Seaman, Alejandra Ramos, Pascal Poignard, Adrien Favier, Jean-Pierre Simorre, Robin A. Weiss, C. Theo Verrips, Winfried Weissenhorn, Lucy Rutten

Influenza Virus Aerosols in Human Exhaled Breath: Particle Size, Culturability, and Effect of Surgical Masks

Donald K. Milton, M. Patricia Fabian, Benjamin J. Cowling, Michael L. Grantham, James J. McDevitt

Candida albicans White and Opaque Cells Undergo Distinct Programs of Filamentous Growth

Haoyu Si, Aaron D. Hernday, Matthew P. Hirakawa, Alexander D. Johnson, Richard J. Bennett

An Overexpression Screen of Toxoplasma gondii Rab-GTPases Reveals Distinct Transport Routes to the Micronemes

Katrin Kremer, Dirk Kamin, Eva Rittweger, Jonathan Wilkes, Halley Flammer, Sabine Mahler, Joanne Heng, Christopher J. Tonkin, Gordon Langsley, Stefan W. Hell, Vernon B. Carruthers, David J. P. Ferguson, Markus Meissner

Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection

Sebla B. Kutluay, David Perez-Caballero, Paul D. Bieniasz

Trehalose Biosynthesis Promotes Pseudomonas aeruginosa Pathogenicity in Plants

Slavica Djonović, Jonathan M. Urbach, Eliana Drenkard, Jenifer Bush, Rhonda Feinbaum, Jonathan L. Ausubel, David Traficante, Martina Risech, Christine Kocks, Michael A. Fischbach, Gregory P. Priebe, Frederick M. Ausubel

Chronic Wasting Disease in Bank Voles: Characterisation of the Shortest Incubation Time Model for Prion Diseases

Michele Angelo Di Bari, Romolo Nonno, Joaquín Castilla, Claudia D'Agostino, Laura Pirisinu, Geraldina Riccardi, Michela Conte, Juergen Richt, Robert Kunkle, Jan Langeveld, Gabriele Vaccari, Umberto Agrimi