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Table of Contents: January 2015

COVER

Superficial lymphatic vessels and Yersinia pestis.

Image Credit: Rodrigo J. Gonzalez
Issue Image

Superficial lymphatic vessels (green, LYVE-1) are abundant in the dermis and represent an opportunity for Yersinia pestis to escape from the skin and colonize draining lymph nodes. See Virginia Miller and colleagues.

Viewpoints

The Importance of Pathogen Load

Aubrey J. Cunnington

Pearls

Malassezia Infections in Humans and Animals: Pathophysiology, Detection, and Treatment

Aristea Velegraki, Claudia Cafarchia, Georgios Gaitanis, Roberta Iatta, Teun Boekhout

Reviews

Phytomonas: Trypanosomatids Adapted to Plant Environments

Eleanor Jaskowska, Claire Butler, Gail Preston, Steven Kelly

Bacterial Flagella: Twist and Stick, or Dodge across the Kingdoms

Yannick Rossez, Eliza B. Wolfson, Ashleigh Holmes, David L. Gally, Nicola J. Holden

Research Articles

Dengue Virus RNA Structure Specialization Facilitates Host Adaptation

Sergio M. Villordo, Claudia V. Filomatori, Irma Sánchez-Vargas, Carol D. Blair, Andrea V. Gamarnik

Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

Shyamasree De Majumdar, Jing Yu, Maria Fookes, Sean P. McAteer, Enrique Llobet, Sarah Finn, Shaun Spence, Avril Monaghan, Adrien Kissenpfennig, Rebecca J. Ingram, José Bengoechea, David L. Gally, Séamus Fanning, Joseph S. Elborn, Thamarai Schneiders

IL-1α Signaling Is Critical for Leukocyte Recruitment after Pulmonary Aspergillus fumigatus Challenge

Alayna K. Caffrey, Margaret M. Lehmann, Julianne M. Zickovich, Vanessa Espinosa, Kelly M. Shepardson, Christopher P. Watschke, Kimberly M. Hilmer, Arsa Thammahong, Bridget M. Barker, Amariliz Rivera, Robert A. Cramer, Joshua J. Obar

The M3 Muscarinic Receptor Is Required for Optimal Adaptive Immunity to Helminth and Bacterial Infection

Matthew Darby, Corinna Schnoeller, Alykhan Vira, Fiona Culley, Saeeda Bobat, Erin Logan, Frank Kirstein, Jürgen Wess, Adam F. Cunningham, Frank Brombacher, Murray E. Selkirk, William G. C. Horsnell

Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection

Anupam Jhingran, Shinji Kasahara, Kelly M. Shepardson, Beth A. Fallert Junecko, Lena J. Heung, Debra K. Kumasaka, Sue E. Knoblaugh, Xin Lin, Barbara I. Kazmierczak, Todd A. Reinhart, Robert A. Cramer, Tobias M. Hohl

A Human Type 5 Adenovirus-Based Trypanosoma cruzi Therapeutic Vaccine Re-programs Immune Response and Reverses Chronic Cardiomyopathy

Isabela Resende Pereira, Glaucia Vilar-Pereira, Virgínia Marques, Andrea Alice da Silva, Bráulia Caetano, Otacilio Cruz Moreira, Alexandre Vieira Machado, Oscar Bruna-Romero, Maurício Martins Rodrigues, Ricardo Tostes Gazzinelli, Joseli Lannes-Vieira

Cell Cycle-Independent Phospho-Regulation of Fkh2 during Hyphal Growth Regulates Candida albicans Pathogenesis

Jamie A. Greig, Ian M. Sudbery, Jonathan P. Richardson, Julian R. Naglik, Yue Wang, Peter E. Sudbery

TLR3 Signaling in Macrophages Is Indispensable for the Protective Immunity of Invariant Natural Killer T Cells against Enterovirus 71 Infection

Kai Zhu, Juhao Yang, Kaiming Luo, Chunhui Yang, Na Zhang, Ruifeng Xu, Jianxia Chen, Mingfei Jin, Bin Xu, Nining Guo, Jianrong Wang, Zuolong Chen, Ying Cui, Hui Zhao, Yan Wang, Chaoyang Deng, Li Bai, Baoxue Ge, Cheng-Feng Qin, Hao Shen, Chun-Fu Yang, Qibin Leng

Regulation of Oncogene Expression in T-DNA-Transformed Host Plant Cells

Yi Zhang, Chil-Woo Lee, Nora Wehner, Fabian Imdahl, Veselova Svetlana, Christoph Weiste, Wolfgang Dröge-Laser, Rosalia Deeken

Secreted Herpes Simplex Virus-2 Glycoprotein G Modifies NGF-TrkA Signaling to Attract Free Nerve Endings to the Site of Infection

Jorge Rubén Cabrera, Abel Viejo-Borbolla, Nadia Martinez-Martín, Soledad Blanco, Francisco Wandosell, Antonio Alcamí

Dissemination of a Highly Virulent Pathogen: Tracking The Early Events That Define Infection

Rodrigo J. Gonzalez, M. Chelsea Lane, Nikki J. Wagner, Eric H. Weening, Virginia L. Miller

Variability in Tuberculosis Granuloma T Cell Responses Exists, but a Balance of Pro- and Anti-inflammatory Cytokines Is Associated with Sterilization

Hannah Priyadarshini Gideon, JiaYao Phuah, Amy J. Myers, Bryan D. Bryson, Mark A. Rodgers, M. Teresa Coleman, Pauline Maiello, Tara Rutledge, Simeone Marino, Sarah M. Fortune, Denise E. Kirschner, Philana Ling Lin, JoAnne L. Flynn

Chronic Filarial Infection Provides Protection against Bacterial Sepsis by Functionally Reprogramming Macrophages

Fabian Gondorf, Afiat Berbudi, Benedikt C. Buerfent, Jesuthas Ajendra, Dominique Bloemker, Sabine Specht, David Schmidt, Anna-Lena Neumann, Laura E. Layland, Achim Hoerauf, Marc P. Hübner

Specificity and Dynamics of Effector and Memory CD8 T Cell Responses in Human Tick-Borne Encephalitis Virus Infection

Kim Blom, Monika Braun, Jolita Pakalniene, Laura Dailidyte, Vivien Béziat, Margit H. Lampen, Jonas Klingström, Nina Lagerqvist, Torbjörn Kjerstadius, Jakob Michaëlsson, Lars Lindquist, Hans-Gustaf Ljunggren, Johan K. Sandberg, Aukse Mickiene, Sara Gredmark-Russ

GITR Intrinsically Sustains Early Type 1 and Late Follicular Helper CD4 T Cell Accumulation to Control a Chronic Viral Infection

Derek L. Clouthier, Angela C. Zhou, Michael E. Wortzman, Olga Luft, Gary A. Levy, Tania H. Watts

The Epstein-Barr Virus Encoded BART miRNAs Potentiate Tumor Growth In Vivo

Jin Qiu, Pamela Smith, Leah Leahy, David A. Thorley-Lawson

DNA Is an Antimicrobial Component of Neutrophil Extracellular Traps

Tyler W.R. Halverson, Mike Wilton, Karen K. H. Poon, Björn Petri, Shawn Lewenza

Reprogramming of Yersinia from Virulent to Persistent Mode Revealed by Complex In Vivo RNA-seq Analysis

Kemal Avican, Anna Fahlgren, Mikael Huss, Ann Kathrin Heroven, Michael Beckstette, Petra Dersch, Maria Fällman

Promiscuous RNA Binding Ensures Effective Encapsidation of APOBEC3 Proteins by HIV-1

Luis Apolonia, Reiner Schulz, Tomaž Curk, Paula Rocha, Chad M. Swanson, Torsten Schaller, Jernej Ule, Michael H. Malim

Parasite Biomass-Related Inflammation, Endothelial Activation, Microvascular Dysfunction and Disease Severity in Vivax Malaria

Bridget E. Barber, Timothy William, Matthew J. Grigg, Uma Parameswaran, Kim A. Piera, Ric N. Price, Tsin W. Yeo, Nicholas M. Anstey

Transmitted Virus Fitness and Host T Cell Responses Collectively Define Divergent Infection Outcomes in Two HIV-1 Recipients

Ling Yue, Katja J. Pfafferott, Joshua Baalwa, Karen Conrod, Catherine C. Dong, Cecilia Chui, Rong Rong, Daniel T. Claiborne, Jessica L. Prince, Jianming Tang, Ruy M. Ribeiro, Emmanuel Cormier, Beatrice H. Hahn, Alan S. Perelson, George M. Shaw, Etienne Karita, Jill Gilmour, Paul Goepfert, Cynthia A. Derdeyn, Susan A. Allen, Persephone Borrow, Eric Hunter

Well-Ordered Trimeric HIV-1 Subtype B and C Soluble Spike Mimetics Generated by Negative Selection Display Native-like Properties

Javier Guenaga, Natalia de Val, Karen Tran, Yu Feng, Karen Satchwell, Andrew B. Ward, Richard T. Wyatt

Identification of HNRNPK as Regulator of Hepatitis C Virus Particle Production

Marion Poenisch, Philippe Metz, Hagen Blankenburg, Alessia Ruggieri, Ji-Young Lee, Daniel Rupp, Ilka Rebhan, Kathrin Diederich, Lars Kaderali, Francisco S. Domingues, Mario Albrecht, Volker Lohmann, Holger Erfle, Ralf Bartenschlager

Macrophage-Derived Human Resistin Is Induced in Multiple Helminth Infections and Promotes Inflammatory Monocytes and Increased Parasite Burden

Jessica C. Jang, Gang Chen, Spencer H. Wang, Mark A. Barnes, Josiah I. Chung, Mali Camberis, Graham Le Gros, Philip J. Cooper, Cathy Steel, Thomas B. Nutman, Mitchell A. Lazar, Meera G. Nair

Differential Reliance on Autophagy for Protection from HSV Encephalitis between Newborns and Adults

Douglas R. Wilcox, Nitin R. Wadhwani, Richard Longnecker, William J. Muller

Early Virus-Host Interactions Dictate the Course of a Persistent Infection

Brian M. Sullivan, John R. Teijaro, Juan Carlos de la Torre, Michael B. A. Oldstone

Environmental Drivers of the Spatiotemporal Dynamics of Respiratory Syncytial Virus in the United States

Virginia E. Pitzer, Cécile Viboud, Wladimir J. Alonso, Tanya Wilcox, C. Jessica Metcalf, Claudia A. Steiner, Amber K. Haynes, Bryan T. Grenfell

A New Family of Secreted Toxins in Pathogenic Neisseria Species

Anne Jamet, Agnès B. Jousset, Daniel Euphrasie, Paulette Mukorako, Alix Boucharlat, Alexia Ducousso, Alain Charbit, Xavier Nassif

Different Infectivity of HIV-1 Strains Is Linked to Number of Envelope Trimers Required for Entry

Oliver F. Brandenberg, Carsten Magnus, Peter Rusert, Roland R. Regoes, Alexandra Trkola

Uropathogenic Escherichia coli Superinfection Enhances the Severity of Mouse Bladder Infection

Drew J. Schwartz, Matt S. Conover, Thomas J. Hannan, Scott J. Hultgren

The Molecular Basis for Control of ETEC Enterotoxin Expression in Response to Environment and Host

James R. J. Haycocks, Prateek Sharma, Anne M. Stringer, Joseph T. Wade, David C. Grainger

Protective Efficacy of Centralized and Polyvalent Envelope Immunogens in an Attenuated Equine Lentivirus Vaccine

Jodi K. Craigo, Corin Ezzelarab, Sheila J. Cook, Chong Liu, David Horohov, Charles J. Issel, Ronald C. Montelaro