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Table of Contents: November 2014

COVER

Downy mildew infection of Arabidopsis.

Image Credit: Marie-Cécile Caillaud and Sophie Piquerez
Issue Image

Haustoria of the downy mildew pathogen Hyaloperonospora arabidopsidis are progressively encased with callose-rich materials by the host. In this image, the callose in an infected leaf has been stained by aniline blue, tracing the path of the encasement response along the length of the pathogen hyphae. Marie-Cécile Caillaud and colleagues have identified a novel component of the mechanism by which callose is deposited in these encasements, positively regulating host defence.

Opinion

Microbial Contamination in Next Generation Sequencing: Implications for Sequence-Based Analysis of Clinical Samples

Michael J. Strong, Guorong Xu, Lisa Morici, Sandra Splinter Bon-Durant, Melody Baddoo, Zhen Lin, Claire Fewell, Christopher M. Taylor, Erik K. Flemington

Pearls

Peculiarities of Prion Diseases

Walker S. Jackson, Clemens Krost

Review

The Evolution and Genetics of Virus Host Shifts

Ben Longdon, Michael A. Brockhurst, Colin A. Russell, John J. Welch, Francis M. Jiggins

Research Articles

GAPDH-A Recruits a Plant Virus Movement Protein to Cortical Virus Replication Complexes to Facilitate Viral Cell-to-Cell Movement

Masanori Kaido, Kazutomo Abe, Akira Mine, Kiwamu Hyodo, Takako Taniguchi, Hisaaki Taniguchi, Kazuyuki Mise, Tetsuro Okuno

Genetics, Receptor Binding Property, and Transmissibility in Mammals of Naturally Isolated H9N2 Avian Influenza Viruses

Xuyong Li, Jianzhong Shi, Jing Guo, Guohua Deng, Qianyi Zhang, Jinliang Wang, Xijun He, Kaicheng Wang, Jiming Chen, Yuanyuan Li, Jun Fan, Huiui Kong, Chunyang Gu, Yuantao Guan, Yasuo Suzuki, Yoshihiro Kawaoka, Liling Liu, Yongping Jiang, Guobin Tian, Yanbing Li, Zhigao Bu, Hualan Chen

Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability

Beatriz Escudero-Pérez, Valentina A. Volchkova, Olga Dolnik, Philip Lawrence, Viktor E. Volchkov

Succinate Dehydrogenase is the Regulator of Respiration in Mycobacterium tuberculosis

Travis Hartman, Brian Weinrick, Catherine Vilchèze, Michael Berney, Joanne Tufariello, Gregory M. Cook, William R. Jacobs Jr.

Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions

Myriam Scherer, Stefan Klingl, Madhumati Sevvana, Victoria Otto, Eva-Maria Schilling, Joachim D. Stump, Regina Müller, Nina Reuter, Heinrich Sticht, Yves A. Muller, Thomas Stamminger

NK Cell Activation in Human Hantavirus Infection Explained by Virus-Induced IL-15/IL15Rα Expression

Monika Braun, Niklas K. Björkström, Shawon Gupta, Karin Sundström, Clas Ahlm, Jonas Klingström, Hans-Gustaf Ljunggren

Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway

Qing Yao, Li Zhang, Xiaobo Wan, Jing Chen, Liyan Hu, Xiaojun Ding, Lin Li, Jayashree Karar, Hongzhuang Peng, She Chen, Niu Huang, Frank J. Rauscher III, Feng Shao

Human Cytomegalovirus Vaccine Based on the Envelope gH/gL Pentamer Complex

Felix Wussow, Flavia Chiuppesi, Joy Martinez, John Campo, Erica Johnson, Christin Flechsig, Maegan Newell, Elaine Tran, Jose Ortiz, Corinna La Rosa, Andreas Herrmann, Jeff Longmate, Rana Chakraborty, Peter A. Barry, Don J. Diamond

Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy

Julian H. Elliott, Fiona Wightman, Ajantha Solomon, Khader Ghneim, Jeffrey Ahlers, Mark J. Cameron, Miranda Z. Smith, Tim Spelman, James McMahon, Pushparaj Velayudham, Gregor Brown, Janine Roney, Jo Watson, Miles H. Prince, Jennifer F. Hoy, Nicolas Chomont, Rémi Fromentin, Francesco A. Procopio, Joumana Zeidan, Sarah Palmer, Lina Odevall, Ricky W. Johnstone, Ben P. Martin, Elizabeth Sinclair, Steven G. Deeks, Daria J. Hazuda, Paul U. Cameron, Rafick-Pierre Sékaly, Sharon R. Lewin

The Plasmodesmal Protein PDLP1 Localises to Haustoria-Associated Membranes during Downy Mildew Infection and Regulates Callose Deposition

Marie-Cécile Caillaud, Lennart Wirthmueller, Jan Sklenar, Kim Findlay, Sophie J. M. Piquerez, Alexandra M. E. Jones, Silke Robatzek, Jonathan D. G. Jones, Christine Faulkner

Dysregulated B Cell Expression of RANKL and OPG Correlates with Loss of Bone Mineral Density in HIV Infection

Kehmia Titanji, Aswani Vunnava, Anandi N. Sheth, Cecile Delille, Jeffrey L. Lennox, Sara E. Sanford, Antonina Foster, Andrea Knezevic, Kirk A. Easley, M. Neale Weitzmann, Ighovwerha Ofotokun

Restriction of Francisella novicida Genetic Diversity during Infection of the Vector Midgut

Kathryn E. Reif, Guy H. Palmer, David W. Crowder, Massaro W. Ueti, Susan M. Noh

Aminoterminal Amphipathic α-Helix AH1 of Hepatitis C Virus Nonstructural Protein 4B Possesses a Dual Role in RNA Replication and Virus Production

Jérôme Gouttenoire, Roland Montserret, David Paul, Rosa Castillo, Simon Meister, Ralf Bartenschlager, François Penin, Darius Moradpour

Plasticity between MyoC- and MyoA-Glideosomes: An Example of Functional Compensation in Toxoplasma gondii Invasion

Karine Frénal, Jean-Baptiste Marq, Damien Jacot, Valérie Polonais, Dominique Soldati-Favre

PUL21a-Cyclin A2 Interaction is Required to Protect Human Cytomegalovirus-Infected Cells from the Deleterious Consequences of Mitotic Entry

Martin Eifler, Ralf Uecker, Henry Weisbach, Boris Bogdanow, Ellen Richter, Lydia König, Barbara Vetter, Tihana Lenac-Rovis, Stipan Jonjic, Heidemarie Neitzel, Christian Hagemeier, Lüder Wiebusch

Retromer Regulates HIV-1 Envelope Glycoprotein Trafficking and Incorporation into Virions

Elisabetta Groppelli, Alice C. Len, Luke A. Granger, Clare Jolly

Programmed Ribosomal Frameshift Alters Expression of West Nile Virus Genes and Facilitates Virus Replication in Birds and Mosquitoes

Ezequiel Balmori Melian, Sonja Hall-Mendelin, Fangyao Du, Nick Owens, Angela M. Bosco-Lauth, Tomoko Nagasaki, Stephen Rudd, Aaron C. Brault, Richard A. Bowen, Roy A. Hall, Andrew F. van den Hurk, Alexander A. Khromykh

Co-dependence of HTLV-1 p12 and p8 Functions in Virus Persistence

Cynthia A. Pise-Masison, Maria Fernanda de Castro-Amarante, Yoshimi Enose-Akahata, R. Cody Buchmann, Claudio Fenizia, Robyn Washington Parks, Dustin Edwards, Martina Fiocchi, Luiz Carlos Alcantara Jr, Izabela Bialuk, Jhanelle Graham, Jean-Claude Walser, Katherine McKinnon, Bernardo Galvão-Castro, Antoine Gessain, David Venzon, Steven Jacobson, Genoveffa Franchini

IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis

Silvia Moretti, Silvia Bozza, Vasilis Oikonomou, Giorgia Renga, Andrea Casagrande, Rossana G. Iannitti, Matteo Puccetti, Cecilia Garlanda, Soohyun Kim, Suzhao Li, Frank L. van de Veerdonk, Charles A. Dinarello, Luigina Romani

Unravelling Human Trypanotolerance: IL8 is Associated with Infection Control whereas IL10 and TNFα Are Associated with Subsequent Disease Development

Hamidou Ilboudo, Rachel Bras-Gonçalves, Mamadou Camara, Laurence Flori, Oumou Camara, Hassane Sakande, Mamadou Leno, Elodie Petitdidier, Vincent Jamonneau, Bruno Bucheton

Host-Specific Parvovirus Evolution in Nature Is Recapitulated by In Vitro Adaptation to Different Carnivore Species

Andrew B. Allison, Dennis J. Kohler, Alicia Ortega, Elizabeth A. Hoover, Daniel M. Grove, Edward C. Holmes, Colin R. Parrish

The Pseudomonas aeruginosa Type III Translocon Is Required for Biofilm Formation at the Epithelial Barrier

Cindy S. Tran, Stephanie M. Rangel, Henrik Almblad, Arlinet Kierbel, Michael Givskov, Tim Tolker-Nielsen, Alan R. Hauser, Joanne N. Engel

ChIP-seq and In Vivo Transcriptome Analyses of the Aspergillus fumigatus SREBP SrbA Reveals a New Regulator of the Fungal Hypoxia Response and Virulence

Dawoon Chung, Bridget M. Barker, Charles C. Carey, Brittney Merriman, Ernst R. Werner, Beatrix E. Lechner, Sourabh Dhingra, Chao Cheng, Wenjie Xu, Sara J. Blosser, Kengo Morohashi, Aurélien Mazurie, Thomas K. Mitchell, Hubertus Haas, Aaron P. Mitchell, Robert A. Cramer

A Conserved Peptide Pattern from a Widespread Microbial Virulence Factor Triggers Pattern-Induced Immunity in Arabidopsis

Hannah Böhm, Isabell Albert, Stan Oome, Tom M. Raaymakers, Guido Van den Ackerveken, Thorsten Nürnberger

The Relationship between Host Lifespan and Pathogen Reservoir Potential: An Analysis in the System Arabidopsis thaliana-Cucumber mosaic virus

Jean Michel Hily, Adrián García, Arancha Moreno, María Plaza, Mark D. Wilkinson, Alberto Fereres, Aurora Fraile, Fernando García-Arenal

Silencing by H-NS Potentiated the Evolution of Salmonella

Sabrina S. Ali, Jeremy Soo, Chitong Rao, Andrea S. Leung, David Hon-Man Ngai, Alexander W. Ensminger, William Wiley Navarre

Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner

Christine Burkard, Monique H. Verheije, Oliver Wicht, Sander I. van Kasteren, Frank J. van Kuppeveld, Bart L. Haagmans, Lucas Pelkmans, Peter J. M. Rottier, Berend Jan Bosch, Cornelis A. M. de Haan