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Table of Contents: August 2015

Issue Image

Localization of the MyoA-glideosome at the periphery of the parasite (stained with GAP45 in red) and the MyoC-glideosome at the basal polar ring (stained with IAP1-3Ty in green). Frenal et al.

Opinion

Interdisciplinarity and Infectious Diseases: An Ebola Case Study

Vanessa O. Ezenwa, Anne-Helene Prieur-Richard, Benjamin Roche, Xavier Bailly, Pierre Becquart, Gabriel E. García-Peña, Parviez R. Hosseini, Felicia Keesing, Annapaola Rizzoli, Gerardo Suzán, Marco Vignuzzi, Marion Vittecoq, James N. Mills, Jean-François Guégan

Pearls

Chemical Signals and Mechanosensing in Bacterial Responses to Their Environment

Akshay K. Harapanahalli, Jessica A. Younes, Elaine Allan, Henny C. van der Mei, Henk J. Busscher

Riding the R Train into the Cell

Daniel DiMaio, Christopher G. Burd, Kylia Goodner

Are Human Intestinal Eukaryotes Beneficial or Commensals?

Julius Lukeš, Christen Rune Stensvold, Kateřina Jirků-Pomajbíková, Laura Wegener Parfrey

Illuminating Targets of Bacterial Secretion

Roger D. Pechous, William E. Goldman

Fungi That Infect Insects: Altering Host Behavior and Beyond

Yanfang Shang, Peng Feng, Chengshu Wang

Review

Hepcidin and Host Defense against Infectious Diseases

Kathryn Michels, Elizabeta Nemeth, Tomas Ganz, Borna Mehrad

Research Articles

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway

Pierre-Emmanuel Joubert, Kenneth Stapleford, Florence Guivel-Benhassine, Marco Vignuzzi, Olivier Schwartz, Matthew L. Albert

Leptomonas seymouri: Adaptations to the Dixenous Life Cycle Analyzed by Genome Sequencing, Transcriptome Profiling and Co-infection with Leishmania donovani

Natalya Kraeva, Anzhelika Butenko, Jana Hlaváčová, Alexei Kostygov, Jitka Myškova, Danyil Grybchuk, Tereza Leštinová, Jan Votýpka, Petr Volf, Fred Opperdoes, Pavel Flegontov, Julius Lukeš, Vyacheslav Yurchenko

Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways

Nora Grahl, Elora G. Demers, Allia K. Lindsay, Colleen E. Harty, Sven D. Willger, Amy E. Piispanen, Deborah A. Hogan

The Hos2 Histone Deacetylase Controls Ustilago maydis Virulence through Direct Regulation of Mating-Type Genes

Alberto Elías-Villalobos, Alfonso Fernández-Álvarez, Ismael Moreno-Sánchez, Dominique Helmlinger, José I. Ibeas

The Activation of Phytophthora Effector Avr3b by Plant Cyclophilin is Required for the Nudix Hydrolase Activity of Avr3b

Guanghui Kong, Yao Zhao, Maofeng Jing, Jie Huang, Jin Yang, Yeqiang Xia, Liang Kong, Wenwu Ye, Qin Xiong, Yongli Qiao, Suomeng Dong, Wenbo Ma, Yuanchao Wang

Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin Adaptors

Tonya Kueck, Toshana L. Foster, Julia Weinelt, Jonathan C. Sumner, Suzanne Pickering, Stuart J. D. Neil

Twenty-Eight Years of Poliovirus Replication in an Immunodeficient Individual: Impact on the Global Polio Eradication Initiative

Glynis Dunn, Dimitra Klapsa, Thomas Wilton, Lindsay Stone, Philip D. Minor, Javier Martin

The Rsb Phosphoregulatory Network Controls Availability of the Primary Sigma Factor in Chlamydia trachomatis and Influences the Kinetics of Growth and Development

Christopher C. Thompson, Cherry Griffiths, Sophie S. Nicod, Nicole M. Lowden, Sivaramesh Wigneshweraraj, Derek J. Fisher, Myra O. McClure

Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment

Elsa N. Bou Ghanem, Stacie Clark, Sara E. Roggensack, Sally R. McIver, Pilar Alcaide, Philip G. Haydon, John M. Leong

Candida albicans Inhibits Pseudomonas aeruginosa Virulence through Suppression of Pyochelin and Pyoverdine Biosynthesis

Eduardo Lopez-Medina, Di Fan, Laura A. Coughlin, Evi X. Ho, Iain L. Lamont, Cornelia Reimmann, Lora V. Hooper, Andrew Y. Koh

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria

Dor Salomon, John A. Klimko, David C. Trudgian, Lisa N. Kinch, Nick V. Grishin, Hamid Mirzaei, Kim Orth

HLA Class-II Associated HIV Polymorphisms Predict Escape from CD4+ T Cell Responses

Nathan Erdmann, Victor Y. Du, Jonathan Carlson, Malinda Schaefer, Alexander Jureka, Sarah Sterrett, Ling Yue, Dario Dilernia, Shabir Lakhi, Jianming Tang, John Sidney, Jill Gilmour, Susan Allen, Eric Hunter, Sonya Heath, Anju Bansal, Paul A. Goepfert

Trichodysplasia spinulosa-Associated Polyomavirus Uses a Displaced Binding Site on VP1 to Engage Sialylated Glycolipids

Luisa J. Ströh, Gretchen V. Gee, Bärbel S. Blaum, Aisling S. Dugan, Mariet C. W. Feltkamp, Walter J. Atwood, Thilo Stehle

Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection

Edwin Leeansyah, Jenny Svärd, Joana Dias, Marcus Buggert, Jessica Nyström, Máire F. Quigley, Markus Moll, Anders Sönnerborg, Piotr Nowak, Johan K. Sandberg

Inhibiting the Recruitment of PLCγ1 to Kaposi’s Sarcoma Herpesvirus K15 Protein Reduces the Invasiveness and Angiogenesis of Infected Endothelial Cells

Silvia Gramolelli, Magdalena Weidner-Glunde, Bizunesh Abere, Abel Viejo-Borbolla, Kiran Bala, Jessica Rückert, Elisabeth Kremmer, Thomas F. Schulz

Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen

Brandon Sit, Shauna M. Crowley, Kirandeep Bhullar, Christine Chieh-Lin Lai, Calvin Tang, Yogesh Hooda, Charles Calmettes, Husain Khambati, Caixia Ma, John H. Brumell, Anthony B. Schryvers, Bruce A. Vallance, Trevor F. Moraes

Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice

Yu Mitagami, Jun-ichirou Yasunaga, Haruka Kinosada, Koichi Ohshima, Masao Matsuoka

STAT2 Knockout Syrian Hamsters Support Enhanced Replication and Pathogenicity of Human Adenovirus, Revealing an Important Role of Type I Interferon Response in Viral Control

Karoly Toth, Sang R. Lee, Baoling Ying, Jacqueline F. Spencer, Ann E. Tollefson, John E. Sagartz, Il-Keun Kong, Zhongde Wang, William S. M. Wold

sRNA-Mediated Regulation of P-Fimbriae Phase Variation in Uropathogenic Escherichia coli

Surabhi Khandige, Tina Kronborg, Bernt Eric Uhlin, Jakob Møller-Jensen

Which Way In? The RalF Arf-GEF Orchestrates Rickettsia Host Cell Invasion

Kristen E. Rennoll-Bankert, M. Sayeedur Rahman, Joseph J. Gillespie, Mark L. Guillotte, Simran J. Kaur, Stephanie S. Lehman, Magda Beier-Sexton, Abdu F. Azad

HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation

Yik-Khuan Ho, Huijun Zhi, Tara Bowlin, Batsukh Dorjbal, Subha Philip, Muhammad Atif Zahoor, Hsiu-Ming Shih, Oliver John Semmes, Brian Schaefer, J. N. Mark Glover, Chou-Zen Giam

Goblet Cell Derived RELM-β Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation

Kirk S. B. Bergstrom, Vijay Morampudi, Justin M. Chan, Ganive Bhinder, Jennifer Lau, Hyungjun Yang, Caixia Ma, Tina Huang, Natasha Ryz, Ho Pan Sham, Maryam Zarepour, Colby Zaph, David Artis, Meera Nair, Bruce A. Vallance

Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission

Martina Kovarova, Olivia D. Council, Abhijit A. Date, Julie M. Long, Tomonori Nochii, Michael Belshan, Annemarie Shibata, Heather Vincent, Caroline E. Baker, William O. Thayer, Guenter Kraus, Sophie Lachaud-Durand, Peter Williams, Christopher J. Destache, J. Victor Garcia

Mucosal B Cells Are Associated with Delayed SIV Acquisition in Vaccinated Female but Not Male Rhesus Macaques Following SIVmac251 Rectal Challenge

Iskra Tuero, Venkatramanan Mohanram, Thomas Musich, Leia Miller, Diego A. Vargas-Inchaustegui, Thorsten Demberg, David Venzon, Irene Kalisz, V. S. Kalyanaraman, Ranajit Pal, Maria Grazia Ferrari, Celia LaBranche, David C. Montefiori, Mangala Rao, Monica Vaccari, Genoveffa Franchini, Susan W. Barnett, Marjorie Robert-Guroff

Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies

Laura E. McCoy, Emilia Falkowska, Katie J. Doores, Khoa Le, Devin Sok, Marit J. van Gils, Zelda Euler, Judith A. Burger, Michael S. Seaman, Rogier W. Sanders, Hanneke Schuitemaker, Pascal Poignard, Terri Wrin, Dennis R. Burton

Type I IFN Induction via Poly-ICLC Protects Mice against Cryptococcosis

Edward Sionov, Katrin D. Mayer-Barber, Yun C. Chang, Keith D. Kauffman, Michael A. Eckhaus, Andres M. Salazar, Daniel L. Barber, Kyung J. Kwon-Chung

Widespread Reassortment Shapes the Evolution and Epidemiology of Bluetongue Virus following European Invasion

Kyriaki Nomikou, Joseph Hughes, Rachael Wash, Paul Kellam, Emmanuel Breard, Stéphan Zientara, Massimo Palmarini, Roman Biek, Peter Mertens

A Novel Virus Causes Scale Drop Disease in Lates calcarifer

Ad de Groof, Lars Guelen, Martin Deijs, Yorick van der Wal, Masato Miyata, Kah Sing Ng, Lotte van Grinsven, Bartjan Simmelink, Yvonne Biermann, Luc Grisez, Jan van Lent, Anthony de Ronde, Siow Foong Chang, Carla Schrier, Lia van der Hoek

Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates

Enric Vidal, Natalia Fernández-Borges, Belén Pintado, Hasier Eraña, Montserrat Ordóñez, Mercedes Márquez, Francesca Chianini, Dolors Fondevila, Manuel A. Sánchez-Martín, Olivier Andreoletti, Mark P. Dagleish, Martí Pumarola, Joaquín Castilla

Transgenic Rabbits Expressing Ovine PrP Are Susceptible to Scrapie

Pierre Sarradin, Céline Viglietta, Claude Limouzin, Olivier Andréoletti, Nathalie Daniel-Carlier, Céline Barc, Mathieu Leroux-Coyau, Patricia Berthon, Jérôme Chapuis, Christelle Rossignol, Jean-Luc Gatti, Maya Belghazi, Valérie Labas, Jean-Luc Vilotte, Vincent Béringue, Frédéric Lantier, Hubert Laude, Louis-Marie Houdebine

Intracellular Uropathogenic E. coli Exploits Host Rab35 for Iron Acquisition and Survival within Urinary Bladder Cells

Neha Dikshit, Pradeep Bist, Shannon N. Fenlon, Niyas Kudukkil Pulloor, Christelle En Lin Chua, Marci A. Scidmore, Jason A. Carlyon, Bor Luen Tang, Swaine L. Chen, Bindu Sukumaran

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

Sebastian P. Fuchs, José M. Martinez-Navio, Michael Piatak Jr., Jeffrey D. Lifson, Guangping Gao, Ronald C. Desrosiers

A Pyranose-2-Phosphate Motif Is Responsible for Both Antibiotic Import and Quorum-Sensing Regulation in Agrobacterium tumefaciens

Abbas El Sahili, Si-Zhe Li, Julien Lang, Cornelia Virus, Sara Planamente, Mohammed Ahmar, Beatriz G. Guimaraes, Magali Aumont-Nicaise, Armelle Vigouroux, Laurent Soulère, John Reader, Yves Queneau, Denis Faure, Solange Moréra

An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses

Claire A. Schreiber, Toshie Sakuma, Yoshihiro Izumiya, Sara J. Holditch, Raymond D. Hickey, Robert K. Bressin, Upamanyu Basu, Kazunori Koide, Aravind Asokan, Yasuhiro Ikeda

The Two-Phase Emergence of Non Pandemic HIV-1 Group O in Cameroon

Marie Leoz, Felix Feyertag, Anfumbom Kfutwah, Philippe Mauclère, Guillaume Lachenal, Florence Damond, Fabienne De Oliveira, Véronique Lemée, François Simon, David L Robertson, Jean-Christophe Plantier

Double-Edge Sword of Sustained ROCK Activation in Prion Diseases through Neuritogenesis Defects and Prion Accumulation

Aurélie Alleaume-Butaux, Simon Nicot, Mathéa Pietri, Anne Baudry, Caroline Dakowski, Philippe Tixador, Hector Ardila-Osorio, Anne-Marie Haeberlé, Yannick Bailly, Jean-Michel Peyrin, Jean-Marie Launay, Odile Kellermann, Benoit Schneider

Hyperinvasive Meningococci Induce Intra-nuclear Cleavage of the NF-κB Protein p65/RelA by Meningococcal IgA Protease

Anissa Besbes, Salomé Le Goff, Ana Antunes, Aude Terrade, Eva Hong, Dario Giorgini, Muhamed-Kheir Taha, Ala-Eddine Deghmane

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques

Sampa Santra, Georgia D. Tomaras, Ranjit Warrier, Nathan I. Nicely, Hua-Xin Liao, Justin Pollara, Pinghuang Liu, S. Munir Alam, Ruijun Zhang, Sarah L. Cocklin, Xiaoying Shen, Ryan Duffy, Shi-Mao Xia, Robert J. Schutte, Charles W. Pemble IV, S. Moses Dennison, Hui Li, Andrew Chao, Kora Vidnovic, Abbey Evans, Katja Klein, Amit Kumar, James Robinson, Gary Landucci, Donald N. Forthal, David C. Montefiori, Jaranit Kaewkungwal, Sorachai Nitayaphan, Punnee Pitisuttithum, Supachai Rerks-Ngarm, Merlin L. Robb, Nelson L. Michael, Jerome H. Kim, Kelly A. Soderberg, Elena E. Giorgi, Lily Blair, Bette T. Korber, Christiane Moog, Robin J. Shattock, Norman L. Letvin, Joern E. Schmitz, M. A. Moody, Feng Gao, Guido Ferrari, George M. Shaw, Barton F. Haynes

Research Matters