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Table of Contents: March 2015

Issue Image

The image shows PDK1 S135 phosphorylation (green) detected in grade IV GBM tissue together with adjacent “safety margin of healthy looking tissue” (small square). PDK1phosphoS135 was identified by Bär et al., as a potential tumor promoting marker. The phosphoinositide-dependent kinase 1 (PDK1) is a master kinase regulating cell metabolism and survival. PKCη/Rdx-mediated phosphorylation of PDK1:S135 renders the enzyme independent of growth factor signaling through receptor tyrosine kinase and PI3-kinase. This intracellular loop-back pathway was found to be active in cancer but not in normal cells and tissue.

Opinion

Pearls

Catch Me If You Can: The Link between Autophagy and Viruses

Nicholas J. Lennemann, Carolyn B. Coyne

The Great Escape: Pathogen Versus Host

Eric Kong, Mary Ann Jabra-Rizk

Review

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Philipp Kruger, Mona Saffarzadeh, Alexander N. R. Weber, Nikolaus Rieber, Markus Radsak, Horst von Bernuth, Charaf Benarafa, Dirk Roos, Julia Skokowa, Dominik Hartl

Research Articles

Impact of Leishmania Infection on Host Macrophage Nuclear Physiology and Nucleopore Complex Integrity

Amandine Isnard, Jan G. Christian, Mohamed Kodiha, Ursula Stochaj, W. Robert McMaster, Martin Olivier

The Impact of Host Diet on Wolbachia Titer in Drosophila

Laura R. Serbus, Pamela M. White, Jessica Pintado Silva, Amanda Rabe, Luis Teixeira, Roger Albertson, William Sullivan

BILBO1 Is a Scaffold Protein of the Flagellar Pocket Collar in the Pathogen Trypanosoma brucei

Célia Florimond, Annelise Sahin, Keni Vidilaseris, Gang Dong, Nicolas Landrein, Denis Dacheux, Anna Albisetti, Edward H. Byard, Mélanie Bonhivers, Derrick R. Robinson

Low Doses of Imatinib Induce Myelopoiesis and Enhance Host Anti-microbial Immunity

Ruth J. Napier, Brian A. Norris, Alyson Swimm, Cynthia R. Giver, Wayne A. C. Harris, Julie Laval, Brooke A. Napier, Gopi Patel, Ryan Crump, Zhenghong Peng, William Bornmann, Bali Pulendran, R. Mark Buller, David S. Weiss, Rabindra Tirouvanziam, Edmund K. Waller, Daniel Kalman

Transgenic Expression of the Dicotyledonous Pattern Recognition Receptor EFR in Rice Leads to Ligand-Dependent Activation of Defense Responses

Benjamin Schwessinger, Ofir Bahar, Nicolas Thomas, Nicolas Holton, Vladimir Nekrasov, Deling Ruan, Patrick E. Canlas, Arsalan Daudi, Christopher J. Petzold, Vasanth R. Singan, Rita Kuo, Mansi Chovatia, Christopher Daum, Joshua L. Heazlewood, Cyril Zipfel, Pamela C. Ronald

Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection

James P. Hewitson, Kara J. Filbey, Julia Esser-von Bieren, Mali Camberis, Christian Schwartz, Janice Murray, Lisa A. Reynolds, Natalie Blair, Elaine Robertson, Yvonne Harcus, Louis Boon, Stanley Ching-Cheng Huang, Lihua Yang, Yizheng Tu, Mark J. Miller, David Voehringer, Graham Le Gros, Nicola Harris, Rick M. Maizels

Early Virological and Immunological Events in Asymptomatic Epstein-Barr Virus Infection in African Children

Shamanthi Jayasooriya, Thushan I. de Silva, Jainaba Njie-jobe, Chilel Sanyang, Alison M. Leese, Andrew I. Bell, Karen A. McAulay, Peng Yanchun, Heather M. Long, Tao Dong, Hilton C. Whittle, Alan B. Rickinson, Sarah L. Rowland-Jones, Andrew D. Hislop, Katie L. Flanagan

Japanese Encephalitis Virus Nonstructural Protein NS5 Interacts with Mitochondrial Trifunctional Protein and Impairs Fatty Acid β-Oxidation

Yu-Ting Kao, Bi-Lan Chang, Jian-Jong Liang, Hang-Jen Tsai, Yi-Ling Lee, Ren-Jye Lin, Yi-Ling Lin

Decreased HIV-Specific T-Regulatory Responses Are Associated with Effective DC-Vaccine Induced Immunity

Vedran Brezar, Nicolas Ruffin, Laura Richert, Mathieu Surenaud, Christine Lacabaratz, Karolina Palucka, Rodolphe Thiébaut, Jacques Banchereau, Yves Levy, Nabila Seddiki

Exome and Transcriptome Sequencing of Aedes aegypti Identifies a Locus That Confers Resistance to Brugia malayi and Alters the Immune Response

Punita Juneja, Cristina V. Ariani, Yung Shwen Ho, Jewelna Akorli, William J. Palmer, Arnab Pain, Francis M. Jiggins

PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation

Zexing Li, Ge Liu, Liwei Sun, Yan Teng, Xuejiang Guo, Jianhang Jia, Jiahao Sha, Xiao Yang, Dahua Chen, Qinmiao Sun

Lipidomic Analysis Links Mycobactin Synthase K to Iron Uptake and Virulence in M. tuberculosis

Cressida A. Madigan, Amanda Jezek Martinot, Jun-Rong Wei, Ashoka Madduri, Tan-Yun Cheng, David C. Young, Emilie Layre, Jeffrey P. Murry, Eric J. Rubin, D. Branch Moody

Parallel Epigenomic and Transcriptomic Responses to Viral Infection in Honey Bees (Apis mellifera)

David A. Galbraith, Xingyu Yang, Elina Lastro Niño, Soojin Yi, Christina Grozinger

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

Christa Buckheit Sturdevant, Sarah B. Joseph, Gretja Schnell, Richard W. Price, Ronald Swanstrom, Serena Spudich

Herpesviral G Protein-Coupled Receptors Activate NFAT to Induce Tumor Formation via Inhibiting the SERCA Calcium ATPase

Junjie Zhang, Shanping He, Yi Wang, Kevin Brulois, Ke Lan, Jae U. Jung, Pinghui Feng

Induction of Interferon-Stimulated Genes by IRF3 Promotes Replication of Toxoplasma gondii

Tanmay Majumdar, Saurabh Chattopadhyay, Evgeny Ozhegov, Jayeeta Dhar, Ramansu Goswami, Ganes C. Sen, Sailen Barik

Roles and Programming of Arabidopsis ARGONAUTE Proteins during Turnip Mosaic Virus Infection

Hernan Garcia-Ruiz, Alberto Carbonell, J. Steen Hoyer, Noah Fahlgren, Kerrigan B. Gilbert, Atsushi Takeda, Annalisa Giampetruzzi, Mayra T. Garcia Ruiz, Michaela G. McGinn, Nicholas Lowery, Maria T. Martinez Baladejo, James C. Carrington

Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer

Ronald Derking, Gabriel Ozorowski, Kwinten Sliepen, Anila Yasmeen, Albert Cupo, Jonathan L. Torres, Jean-Philippe Julien, Jeong Hyun Lee, Thijs van Montfort, Steven W. de Taeye, Mark Connors, Dennis R. Burton, Ian A. Wilson, Per-Johan Klasse, Andrew B. Ward, John P. Moore, Rogier W. Sanders

Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair

Julia Esser-von Bieren, Beatrice Volpe, Duncan B. Sutherland, Jérôme Bürgi, J. Sjef Verbeek, Benjamin J. Marsland, Joseph F. Urban Jr, Nicola L. Harris

Structure of the Low pH Conformation of Chandipura Virus G Reveals Important Features in the Evolution of the Vesiculovirus Glycoprotein

Eduard Baquero, Aurélie A. Albertini, Hélène Raux, Linda Buonocore, John K. Rose, Stéphane Bressanelli, Yves Gaudin

Persistence of Transmitted HIV-1 Drug Resistance Mutations Associated with Fitness Costs and Viral Genetic Backgrounds

Wan-Lin Yang, Roger D. Kouyos, Jürg Böni, Sabine Yerly, Thomas Klimkait, Vincent Aubert, Alexandra U. Scherrer, Mohaned Shilaih, Trevor Hinkley, Christos Petropoulos, Sebastian Bonhoeffer, Huldrych F. Günthard , the Swiss HIV Cohort Study (SHCS)

The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

Lonneke van der Linden, Laia Vives-Adrián, Barbara Selisko, Cristina Ferrer-Orta, Xinran Liu, Kjerstin Lanke, Rachel Ulferts, Armando M. De Palma, Federica Tanchis, Nesya Goris, David Lefebvre, Kris De Clercq, Pieter Leyssen, Céline Lacroix, Gerhard Pürstinger, Bruno Coutard, Bruno Canard, David D. Boehr, Jamie J. Arnold, Craig E. Cameron, Nuria Verdaguer, Johan Neyts, Frank J. M. van Kuppeveld

An 18 kDa Scaffold Protein Is Critical for Staphylococcus epidermidis Biofilm Formation

Rahel Decker, Christoph Burdelski, Melanie Zobiak, Henning Büttner, Gefion Franke, Martin Christner, Katharina Saß, Bernd Zobiak, Hanae A. Henke, Alexander R. Horswill, Markus Bischoff, Stephanie Bur, Torsten Hartmann, Carolyn R. Schaeffer, Paul D. Fey, Holger Rohde

An O Antigen Capsule Modulates Bacterial Pathogenesis in Shigella sonnei

Mariaelena Caboni, Thierry Pédron, Omar Rossi, David Goulding, Derek Pickard, Francesco Citiulo, Calman A. MacLennan, Gordon Dougan, Nicholas R. Thomson, Allan Saul, Philippe J. Sansonetti, Christiane Gerke

NEDDylation Is Essential for Kaposi’s Sarcoma-Associated Herpesvirus Latency and Lytic Reactivation and Represents a Novel Anti-KSHV Target

David J. Hughes, Jennifer J. Wood, Brian R. Jackson, Belinda Baquero-Pérez, Adrian Whitehouse

Rhadinovirus Host Entry by Co-operative Infection

Clara Lawler, Ricardo Milho, Janet S. May, Philip G. Stevenson

A Plasmodium Phospholipase Is Involved in Disruption of the Liver Stage Parasitophorous Vacuole Membrane

Paul-Christian Burda, Matthias A. Roelli, Marco Schaffner, Shahid M. Khan, Chris J. Janse, Volker T. Heussler

Yersinia pestis Activates Both IL-1β and IL-1 Receptor Antagonist to Modulate Lung Inflammation during Pneumonic Plague

Vijay Sivaraman, Roger D. Pechous, Nikolas M. Stasulli, Edward A. Miao, William E. Goldman

Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape

Jens Dinter, Ellen Duong, Nicole Y. Lai, Matthew J. Berberich, Georgio Kourjian, Edith Bracho-Sanchez, Duong Chu, Hang Su, Shao Chong Zhang, Sylvie Le Gall

Escherichia coli α-Hemolysin Counteracts the Anti-Virulence Innate Immune Response Triggered by the Rho GTPase Activating Toxin CNF1 during Bacteremia

Mamady Diabate, Patrick Munro, Elsa Garcia, Arnaud Jacquel, Gregory Michel, Sandrine Obba, Diogo Goncalves, Carmelo Luci, Sandrine Marchetti, Dieter Demon, Clara Degos, Yassina Bechah, Jean-Louis Mege, Mohamed Lamkanfi, Patrick Auberger, Jean-Pierre Gorvel, Lynda Maria Stuart, Luce Landraud, Emmanuel Lemichez, Laurent Boyer

Evidence for Ubiquitin-Regulated Nuclear and Subnuclear Trafficking among Paramyxovirinae Matrix Proteins

Mickey Pentecost, Ajay A. Vashisht, Talia Lester, Tim Voros, Shannon M. Beaty, Arnold Park, Yao E. Wang, Tatyana E Yun, Alexander N. Freiberg, James A. Wohlschlegel, Benhur Lee

Elucidation of Sigma Factor-Associated Networks in Pseudomonas aeruginosa Reveals a Modular Architecture with Limited and Function-Specific Crosstalk

Sebastian Schulz, Denitsa Eckweiler, Agata Bielecka, Tanja Nicolai, Raimo Franke, Andreas Dötsch, Klaus Hornischer, Sebastian Bruchmann, Juliane Düvel, Susanne Häussler

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

Yongqian Zhao, Tingjin Sherryl Soh, Jie Zheng, Kitti Wing Ki Chan, Wint Wint Phoo, Chin Chin Lee, Moon Y. F. Tay, Kunchithapadam Swaminathan, Tobias C. Cornvik, Siew Pheng Lim, Pei-Yong Shi, Julien Lescar, Subhash G. Vasudevan, Dahai Luo

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose

Darren J. Creek, Muriel Mazet, Fiona Achcar, Jana Anderson, Dong-Hyun Kim, Ruwida Kamour, Pauline Morand, Yoann Millerioux, Marc Biran, Eduard J. Kerkhoven, Achuthanunni Chokkathukalam, Stefan K. Weidt, Karl E. V. Burgess, Rainer Breitling, David G. Watson, Frédéric Bringaud, Michael P. Barrett

Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Requires CADM1/TSLC1 for Inactivation of the NF-κB Inhibitor A20 and Constitutive NF-κB Signaling

Rajeshree Pujari, Richard Hunte, Remy Thomas, Louise van der Weyden, Dan Rauch, Lee Ratner, Jennifer K. Nyborg, Juan Carlos Ramos, Yoshimi Takai, Noula Shembade

The Causes and Consequences of Changes in Virulence following Pathogen Host Shifts

Ben Longdon, Jarrod D. Hadfield, Jonathan P. Day, Sophia C. L. Smith, John E. McGonigle, Rodrigo Cogni, Chuan Cao, Francis M. Jiggins

A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication

Olaf Isken, Ulrike Langerwisch, Vlastimil Jirasko, Dirk Rehders, Lars Redecke, Harish Ramanathan, Brett D. Lindenbach, Ralf Bartenschlager, Norbert Tautz

Adenovirus Entry From the Apical Surface of Polarized Epithelia Is Facilitated by the Host Innate Immune Response

Poornima L. N. Kotha, Priyanka Sharma, Abimbola O. Kolawole, Ran Yan, Mahmoud S. Alghamri, Trisha L. Brockman, Julian Gomez-Cambronero, Katherine J. D. A. Excoffon

Production of Anti-LPS IgM by B1a B Cells Depends on IL-1β and Is Protective against Lung Infection with Francisella tularensis LVS

Laura del Barrio, Manoranjan Sahoo, Louis Lantier, Joseph M. Reynolds, Ivonne Ceballos-Olvera, Fabio Re

Characterization of CD8+ T Cell Differentiation following SIVΔnef Vaccination by Transcription Factor Expression Profiling

James M. Billingsley, Premeela A. Rajakumar, Michelle A. Connole, Nadine C. Salisch, Sama Adnan, Yury V. Kuzmichev, Henoch S. Hong, R. Keith Reeves, Hyung-joo Kang, Wenjun Li, Qingsheng Li, Ashley T. Haase, R. Paul Johnson

RSV Vaccine-Enhanced Disease Is Orchestrated by the Combined Actions of Distinct CD4 T Cell Subsets

Cory J. Knudson, Stacey M. Hartwig, David K. Meyerholz, Steven M. Varga

Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Oxidized Biopterins in Pediatric Falciparum Malaria: Association with Disease Severity

Matthew P. Rubach, Jackson Mukemba, Salvatore Florence, Bert K. Lopansri, Keith Hyland, Alicia D. Volkheimer, Tsin W. Yeo, Nicholas M. Anstey, J. Brice Weinberg, Esther D. Mwaikambo, Donald L. Granger

Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection

Darin L. Wiesner, Charles A. Specht, Chrono K. Lee, Kyle D. Smith, Liliane Mukaremera, S. Thera Lee, Chun G. Lee, Jack A. Elias, Judith N. Nielsen, David R. Boulware, Paul R. Bohjanen, Marc K. Jenkins, Stuart M. Levitz, Kirsten Nielsen

Disruption of IL-21 Signaling Affects T Cell-B Cell Interactions and Abrogates Protective Humoral Immunity to Malaria

Damián Pérez-Mazliah, Dorothy Hui Lin Ng, Ana Paula Freitas do Rosário, Sarah McLaughlin, Béatris Mastelic-Gavillet, Jan Sodenkamp, Garikai Kushinga, Jean Langhorne

Dependence of Intracellular and Exosomal microRNAs on Viral E6/E7 Oncogene Expression in HPV-positive Tumor Cells

Anja Honegger, Daniela Schilling, Sandra Bastian, Jasmin Sponagel, Vladimir Kuryshev, Holger Sültmann, Martin Scheffner, Karin Hoppe-Seyler, Felix Hoppe-Seyler

Vaccinia Virus Protein Complex F12/E2 Interacts with Kinesin Light Chain Isoform 2 to Engage the Kinesin-1 Motor Complex

David C. J. Carpentier, William N. D. Gao, Helen Ewles, Gareth W. Morgan, Geoffrey L. Smith

Establishment of HSV1 Latency in Immunodeficient Mice Facilitates Efficient In Vivo Reactivation

Chandran Ramakrishna, Adrianna Ferraioli, Aleth Calle, Thanh K. Nguyen, Harry Openshaw, Patric S. Lundberg, Patrick Lomonte, Edouard M. Cantin

Metalloprotease NleC Suppresses Host NF-κB/Inflammatory Responses by Cleaving p65 and Interfering with the p65/RPS3 Interaction

Andrea Hodgson, Eric M. Wier, Kai Fu, Xin Sun, Hongbing Yu, Wenxin Zheng, Ho Pan Sham, Kaitlin Johnson, Scott Bailey, Bruce A. Vallance, Fengyi Wan

γδ T Cells Confer Protection against Murine Cytomegalovirus (MCMV)

Camille Khairallah, Sonia Netzer, Arnaud Villacreces, Marina Juzan, Benoît Rousseau, Sara Dulanto, Alban Giese, Pierre Costet, Vincent Praloran, Jean-François Moreau, Pierre Dubus, David Vermijlen, Julie Déchanet-Merville, Myriam Capone

XRN1 Stalling in the 5’ UTR of Hepatitis C Virus and Bovine Viral Diarrhea Virus Is Associated with Dysregulated Host mRNA Stability

Stephanie L. Moon, Jeffrey G. Blackinton, John R. Anderson, Mary K. Dozier, Benjamin J. T. Dodd, Jack D. Keene, Carol J. Wilusz, Shelton S. Bradrick, Jeffrey Wilusz

Suppression of RNAi by dsRNA-Degrading RNaseIII Enzymes of Viruses in Animals and Plants

Isabel Weinheimer, Yaming Jiu, Minna-Liisa Rajamäki, Olli Matilainen, Jukka Kallijärvi, Wilmer J. Cuellar, Rui Lu, Mart Saarma, Carina I. Holmberg, Jussi Jäntti, Jari P. T. Valkonen

Visualization of HIV-1 Interactions with Penile and Foreskin Epithelia: Clues for Female-to-Male HIV Transmission

Minh H. Dinh, Meegan R. Anderson, Michael D. McRaven, Gianguido C. Cianci, Scott G. McCoombe, Z. L. Kelley, Casey J. Gioia, Angela J. Fought, Alfred W. Rademaker, Ronald S. Veazey, Thomas J. Hope

Host ESCRT Proteins Are Required for Bromovirus RNA Replication Compartment Assembly and Function

Arturo Diaz, Jiantao Zhang, Abigail Ollwerther, Xiaofeng Wang, Paul Ahlquist

Subgingival Microbial Communities in Leukocyte Adhesion Deficiency and Their Relationship with Local Immunopathology

Niki M. Moutsopoulos, Natalia I. Chalmers, Jennifer J. Barb, Loreto Abusleme, Teresa Greenwell-Wild, Nicolas Dutzan, Bruce J. Paster, Peter J. Munson, Daniel H. Fine, Gulbu Uzel, Steven M. Holland

Yip1A, a Novel Host Factor for the Activation of the IRE1 Pathway of the Unfolded Protein Response during Brucella Infection

Yuki Taguchi, Koichi Imaoka, Michiyo Kataoka, Akihiko Uda, Daiki Nakatsu, Sakuya Horii-Okazaki, Rina Kunishige, Fumi Kano, Masayuki Murata

Enhanced CD8 T Cell Responses through GITR-Mediated Costimulation Resolve Chronic Viral Infection

Maria Fernanda Pascutti, Sulima Geerman, Edith Slot, Klaas P. J. M. van Gisbergen, Louis Boon, Ramon Arens, Rene A. W van Lier, Monika C. Wolkers, Martijn A. Nolte

Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis

Diana Moreira, Vasco Rodrigues, Maria Abengozar, Luis Rivas, Eduardo Rial, Mireille Laforge, Xiaoling Li, Marc Foretz, Benoit Viollet, Jérôme Estaquier, Anabela Cordeiro da Silva, Ricardo Silvestre

Diminished Reovirus Capsid Stability Alters Disease Pathogenesis and Littermate Transmission

Joshua D. Doyle, Jennifer E. Stencel-Baerenwald, Courtney A. Copeland, Jillian P. Rhoads, Judy J. Brown, Kelli L. Boyd, James B. Atkinson, Terence S. Dermody

Interaction between the Type III Effector VopO and GEF-H1 Activates the RhoA-ROCK Pathway

Hirotaka Hiyoshi, Ryu Okada, Shigeaki Matsuda, Kazuyoshi Gotoh, Yukihiro Akeda, Tetsuya Iida, Toshio Kodama

Adhesive Fiber Stratification in Uropathogenic Escherichia coli Biofilms Unveils Oxygen-Mediated Control of Type 1 Pili

Kyle A. Floyd, Jessica L. Moore, Allison R. Eberly, James A. D. Good, Carrie L. Shaffer, Himesh Zaver, Fredrik Almqvist, Eric P. Skaar, Richard M. Caprioli, Maria Hadjifrangiskou

Virulence Regulation with Venus Flytrap Domains: Structure and Function of the Periplasmic Moiety of the Sensor-Kinase BvgS

Elian Dupré, Julien Herrou, Marc F. Lensink, René Wintjens, Alexey Vagin, Andrey Lebedev, Sean Crosson, Vincent Villeret, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson

Sensing Cytosolic RpsL by Macrophages Induces Lysosomal Cell Death and Termination of Bacterial Infection

Wenhan Zhu, Lili Tao, Marsha L. Quick, Johanna A. Joyce, Jie-Ming Qu, Zhao-Qing Luo

Attenuation of Tick-Borne Encephalitis Virus Using Large-Scale Random Codon Re-encoding

Lauriane de Fabritus, Antoine Nougairède, Fabien Aubry, Ernest A Gould, Xavier de Lamballerie