# wombat urls ß PLOS Pathogens: A Peer-Reviewed Open-Access Journal
Advertisement

Table of Contents: April 2015

Issue Image

The circular epidemic front segregates into single-virus sectors (blue and green sectors), even though the two marked phages have the same genetic background and the epidemic is inoculated as a dot of a homogeneous mixture of the strains. Stochastic sampling in the epidemic wave and exclusion of superinfection of the competing phage might be at the origin of this effect. This picture illustrates the intricate effects that spatial structure and vertical transmission introduce into the spread of epidemics. Berngruber et al.

Opinion

Pearls

Review

Viral Inhibition of the Transporter Associated with Antigen Processing (TAP): A Striking Example of Functional Convergent Evolution

Marieke C. Verweij, Daniëlle Horst, Bryan D. Griffin, Rutger D. Luteijn, Andrew J. Davison, Maaike E. Ressing, Emmanuel J. H. J. Wiertz

Research Articles

Heterologous Expression in Remodeled C. elegans: A Platform for Monoaminergic Agonist Identification and Anthelmintic Screening

Wenjing Law, Leah M. Wuescher, Amanda Ortega, Vera M. Hapiak, Patricia R. Komuniecki, Richard Komuniecki

Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection

Ann E. Lin, Federico C. Beasley, Joshua Olson, Nadia Keller, Robert A. Shalwitz, Thomas J. Hannan, Scott J. Hultgren, Victor Nizet

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon

Josephine M. Reynaud, Dal Young Kim, Svetlana Atasheva, Aliaksandra Rasalouskaya, James P. White, Michael S. Diamond, Scott C. Weaver, Elena I. Frolova, Ilya Frolov

Borna Disease Virus Phosphoprotein Impairs the Developmental Program Controlling Neurogenesis and Reduces Human GABAergic Neurogenesis

Chloé Scordel, Alexandra Huttin, Marielle Cochet-Bernoin, Marion Szelechowski, Aurélie Poulet, Jennifer Richardson, Alexandra Benchoua, Daniel Gonzalez-Dunia, Marc Eloit, Muriel Coulpier

Sigma Factor SigB Is Crucial to Mediate Staphylococcus aureus Adaptation during Chronic Infections

Lorena Tuchscherr, Markus Bischoff, Santiago M. Lattar, Mariangeles Noto Llana, Henrike Pförtner, Silke Niemann, Jennifer Geraci, Hélène Van de Vyver, Martin J. Fraunholz, Ambrose L. Cheung, Mathias Herrmann, Uwe Völker, Daniel O. Sordelli, Georg Peters, Bettina Löffler

Optineurin Regulates the Interferon Response in a Cell Cycle-Dependent Manner

Pierre Génin, Frédérique Cuvelier, Sandrine Lambin, Josina Côrte-Real Filipe, Elodie Autrusseau, Christine Laurent, Emmanuel Laplantine, Robert Weil

A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes

Xiaoping Xiao, Rudian Zhang, Xiaojing Pang, Guodong Liang, Penghua Wang, Gong Cheng

An Effector Peptide Family Required for Drosophila Toll-Mediated Immunity

Alexa W. Clemmons, Scott A. Lindsay, Steven A. Wasserman

The Immune Adaptor ADAP Regulates Reciprocal TGF-β1-Integrin Crosstalk to Protect from Influenza Virus Infection

Chunyang Li, Shaozhuo Jiao, Guojun Wang, Yunzhen Gao, Chang Liu, Xijun He, Chi Zhang, Jun Xiao, Weiyun Li, Guoquan Zhang, Bin Wei, Hualan Chen, Hongyan Wang

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence

Liliana Losada, Janyce A. Sugui, Michael A. Eckhaus, Yun C. Chang, Stephanie Mounaud, Abigail Figat, Vinita Joardar, Suman B. Pakala, Suchitra Pakala, Pratap Venepally, Natalie Fedorova, William C. Nierman, Kyung J. Kwon-Chung

EphrinA2 Receptor (EphA2) Is an Invasion and Intracellular Signaling Receptor for Chlamydia trachomatis

Prema Subbarayal, Karthika Karunakaran, Ann-Cathrin Winkler, Marion Rother, Erik Gonzalez, Thomas F. Meyer, Thomas Rudel

Dual miRNA Targeting Restricts Host Range and Attenuates Neurovirulence of Flaviviruses

Konstantin A. Tsetsarkin, Guangping Liu, Heather Kenney, Jose Bustos-Arriaga, Christopher T. Hanson, Stephen S. Whitehead, Alexander G. Pletnev

Hepatitis D Virus Infection of Mice Expressing Human Sodium Taurocholate Co-transporting Polypeptide

Wenhui He, Bijie Ren, Fengfeng Mao, Zhiyi Jing, Yunfei Li, Yang Liu, Bo Peng, Huan Yan, Yonghe Qi, Yinyan Sun, Ju-Tao Guo, Jianhua Sui, Fengchao Wang, Wenhui Li

Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung

Hock L. Tay, Gerard E. Kaiko, Maximilian Plank, JingJing Li, Steven Maltby, Ama-Tawiah Essilfie, Andrew Jarnicki, Ming Yang, Joerg Mattes, Philip M. Hansbro, Paul S. Foster

Neutrophil Recruitment to Lymph Nodes Limits Local Humoral Response to Staphylococcus aureus

Olena Kamenyeva, Cedric Boularan, Juraj Kabat, Gordon Y. C. Cheung, Claudia Cicala, Anthony J. Yeh, June L. Chan, Saravanan Periasamy, Michael Otto, John H. Kehrl

A Redox Regulatory System Critical for Mycobacterial Survival in Macrophages and Biofilm Development

Kerstin A. Wolff, Andres H. de la Peña, Hoa T. Nguyen, Thanh H. Pham, L. Mario Amzel, Sandra B. Gabelli, Liem Nguyen

Endopeptidase-Mediated Beta Lactam Tolerance

Tobias Dörr, Brigid M. Davis, Matthew K. Waldor

The Epigenetic Regulator G9a Mediates Tolerance to RNA Virus Infection in Drosophila

Sarah H. Merkling, Alfred W. Bronkhorst, Jamie M. Kramer, Gijs J. Overheul, Annette Schenck, Ronald P. Van Rij

Transgenic Fatal Familial Insomnia Mice Indicate Prion Infectivity-Independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease

Ihssane Bouybayoune, Susanna Mantovani, Federico Del Gallo, Ilaria Bertani, Elena Restelli, Liliana Comerio, Laura Tapella, Francesca Baracchi, Natalia Fernández-Borges, Michela Mangieri, Cinzia Bisighini, Galina V. Beznoussenko, Alessandra Paladini, Claudia Balducci, Edoardo Micotti, Gianluigi Forloni, Joaquín Castilla, Fabio Fiordaliso, Fabrizio Tagliavini, Luca Imeri, Roberto Chiesa

Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

Kipyegon Kitur, Dane Parker, Pamela Nieto, Danielle S. Ahn, Taylor S. Cohen, Samuel Chung, Sarah Wachtel, Susan Bueno, Alice Prince

Neofunctionalization of the Sec1 α1,2fucosyltransferase Paralogue in Leporids Contributes to Glycan Polymorphism and Resistance to Rabbit Hemorrhagic Disease Virus

Kristina Nyström, Joana Abrantes, Ana Margarida Lopes, Béatrice Le Moullac-Vaidye, Stéphane Marchandeau, Jézabel Rocher, Nathalie Ruvoën-Clouet, Pedro J. Esteves, Jacques Le Pendu

Conserved Streptococcus pneumoniae Spirosomes Suggest a Single Type of Transformation Pilus in Competence

Raphaël Laurenceau, Petya V. Krasteva, Amy Diallo, Sahra Ouarti, Magalie Duchateau, Christian Malosse, Julia Chamot-Rooke, Rémi Fronzes

Plasma Membrane Profiling Defines an Expanded Class of Cell Surface Proteins Selectively Targeted for Degradation by HCMV US2 in Cooperation with UL141

Jye-Lin Hsu, Dick J. H. van den Boomen, Peter Tomasec, Michael P. Weekes, Robin Antrobus, Richard J. Stanton, Eva Ruckova, Daniel Sugrue, Gavin S. Wilkie, Andrew J. Davison, Gavin W. G. Wilkinson, Paul J. Lehner

Structural Determinants of Phenotypic Diversity and Replication Rate of Human Prions

Jiri G. Safar, Xiangzhu Xiao, Mohammad E. Kabir, Shugui Chen, Chae Kim, Tracy Haldiman, Yvonne Cohen, Wei Chen, Mark L. Cohen, Witold K. Surewicz

Murine CMV-Induced Hearing Loss Is Associated with Inner Ear Inflammation and Loss of Spiral Ganglia Neurons

Russell D. Bradford, Young-Gun Yoo, Mijo Golemac, Ester Pernjak Pugel, Stipan Jonjic, William J. Britt

The Aspartate-Less Receiver (ALR) Domains: Distribution, Structure and Function

Andrew F. Maule, David P. Wright, Joshua J. Weiner, Lanlan Han, Francis C. Peterson, Brian F. Volkman, Nicholas R. Silvaggi, Andrew T. Ulijasz

Relay of Herpes Simplex Virus between Langerhans Cells and Dermal Dendritic Cells in Human Skin

Min Kim, Naomi R. Truong, Virginia James, Lidija Bosnjak, Kerrie J. Sandgren, Andrew N. Harman, Najla Nasr, Kirstie M. Bertram, Norman Olbourne, Shailandra Sawleshwarkar, Kaylene McKinnon, Ralph C. Cohen, Anthony L. Cunningham

Prospective Large-Scale Field Study Generates Predictive Model Identifying Major Contributors to Colony Losses

Merav Gleit Kielmanowicz, Alex Inberg, Inbar Maayan Lerner, Yael Golani, Nicholas Brown, Catherine Louise Turner, Gerald J. R. Hayes, Joan M. Ballam

Hepatitis C Virus RNA Replication Depends on Specific Cis- and Trans-Acting Activities of Viral Nonstructural Proteins

Teymur Kazakov, Feng Yang, Harish N. Ramanathan, Andrew Kohlway, Michael S. Diamond, Brett D. Lindenbach

A Temporal Gate for Viral Enhancers to Co-opt Toll-Like-Receptor Transcriptional Activation Pathways upon Acute Infection

Kai A. Kropp, Wei Yuan Hsieh, Elena Isern, Thorsten Forster, Eva Krause, Wolfram Brune, Ana Angulo, Peter Ghazal

The EBNA3 Family of Epstein-Barr Virus Nuclear Proteins Associates with the USP46/USP12 Deubiquitination Complexes to Regulate Lymphoblastoid Cell Line Growth

Makoto Ohashi, Amy M. Holthaus, Michael A. Calderwood, Chiou-Yan Lai, Bryan Krastins, David Sarracino, Eric Johannsen

Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis

Joseph N. Jarvis, Graeme Meintjes, Tihana Bicanic, Viviana Buffa, Louise Hogan, Stephanie Mo, Gillian Tomlinson, Pascale Kropf, Mahdad Noursadeghi, Thomas S. Harrison

Macrocyclic Lactones Differ in Interaction with Recombinant P-Glycoprotein 9 of the Parasitic Nematode Cylicocylus elongatus and Ketoconazole in a Yeast Growth Assay

Maximiliane Kaschny, Janina Demeler, I. Jana I. Janssen, Tetiana A. Kuzmina, Bruno Besognet, Theo Kanellos, Dominique Kerboeuf, Georg von Samson-Himmelstjerna, Jürgen Krücken

TGF-β Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex

Guoxin Liang, Guangyan Liu, Kouichi Kitamura, Zhe Wang, Sajeda Chowdhury, Ahasan Md Monjurul, Kousho Wakae, Miki Koura, Miyuki Shimadu, Kazuo Kinoshita, Masamichi Muramatsu

Hantaan Virus Infection Induces Both Th1 and ThGranzyme B+ Cell Immune Responses That Associated with Viral Control and Clinical Outcome in Humans

Ying Ma, Bin Yuan, Ran Zhuang, Yusi Zhang, Bei Liu, Chunmei Zhang, Yun Zhang, Haitao Yu, Jing Yi, Angang Yang, Boquan Jin

Selection and Spread of Artemisinin-Resistant Alleles in Thailand Prior to the Global Artemisinin Resistance Containment Campaign

Eldin Talundzic, Sheila Akinyi Okoth, Kanungnit Congpuong, Mateusz M. Plucinski, Lindsay Morton, Ira F. Goldman, Patrick S. Kachur, Chansuda Wongsrichanalai, Wichai Satimai, John W. Barnwell, Venkatachalam Udhayakumar

Global Genome and Transcriptome Analyses of Magnaporthe oryzae Epidemic Isolate 98-06 Uncover Novel Effectors and Pathogenicity-Related Genes, Revealing Gene Gain and Lose Dynamics in Genome Evolution

Yanhan Dong, Ying Li, Miaomiao Zhao, Maofeng Jing, Xinyu Liu, Muxing Liu, Xianxian Guo, Xing Zhang, Yue Chen, Yongfeng Liu, Yanhong Liu, Wenwu Ye, Haifeng Zhang, Yuanchao Wang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang

A Strategy for O-Glycoproteomics of Enveloped Viruses—the O-Glycoproteome of Herpes Simplex Virus Type 1

Ieva Bagdonaite, Rickard Nordén, Hiren J. Joshi, Sally Dabelsteen, Kristina Nyström, Sergey Y. Vakhrushev, Sigvard Olofsson, Hans H. Wandall

Ubiquitous Promoter-Localization of Essential Virulence Regulators in Francisella tularensis

Kathryn M. Ramsey, Melisa L. Osborne, Irina O. Vvedenskaya, Cathy Su, Bryce E. Nickels, Simon L. Dove

Novel Disease Susceptibility Factors for Fungal Necrotrophic Pathogens in Arabidopsis

Albor Dobón, Juan Vicente Canet, Javier García-Andrade, Carlos Angulo, Lutz Neumetzler, Staffan Persson, Pablo Vera