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Table of Contents: January 2016

COVER

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Trichinella spiralis newborn larvae invade skeletal muscle cells, inducing the formation of the unique cell-parasite complex called the nurse cell. Appleton et al.

Opinion

Pearls

A Mother’s Gift: Congenital Transmission of Trypanosoma and Leishmania Species

Tara Grinnage-Pulley, Benjamin Scott, Christine A. Petersen

Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections

Julia A. Messina, Joshua T. Thaden, Batu K. Sharma-Kuinkel, Vance G. Fowler Jr.

Review

Research Articles

Differential Toxicity of Antibodies to the Prion Protein

Regina R. Reimann, Tiziana Sonati, Simone Hornemann, Uli S. Herrmann, Michael Arand, Simon Hawke, Adriano Aguzzi

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection

Jonathan Maelfait, Kenny Roose, Lars Vereecke, Conor Mc Guire, Mozes Sze, Martijn J. Schuijs, Monique Willart, Lorena Itati Ibañez, Hamida Hammad, Bart N. Lambrecht, Rudi Beyaert, Xavier Saelens, Geert van Loo

Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence

Cameron R. Cunningham, Ameya Champhekar, Michael V. Tullius, Barbara Jane Dillon, Anjie Zhen, Justin Rafael de la Fuente, Jonathan Herskovitz, Heidi Elsaesser, Laura M. Snell, Elizabeth B. Wilson, Juan Carlos de la Torre, Scott G. Kitchen, Marcus A. Horwitz, Steven J. Bensinger, Stephen T. Smale, David G. Brooks

Identification of Symptomatic Fetuses Infected with Cytomegalovirus Using Amniotic Fluid Peptide Biomarkers

Cyrille Desveaux, Julie Klein, Marianne Leruez-Ville, Adela Ramirez-Torres, Chrystelle Lacroix, Benjamin Breuil, Carine Froment, Jean-Loup Bascands, Joost P. Schanstra, Yves Ville

A Viral microRNA Cluster Regulates the Expression of PTEN, p27 and of a bcl-2 Homolog

Katharina Bernhardt, Janina Haar, Ming-Han Tsai, Remy Poirey, Regina Feederle, Henri-Jacques Delecluse

Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome

Eddie A. James, Theresa J. Gates, Rebecca E. LaFond, Shinobu Yamamoto, Chester Ni, Duy Mai, Vivian H. Gersuk, Kimberly O’Brien, Quynh-Anh Nguyen, Brad Zeitner, Marion C. Lanteri, Philip J. Norris, Damien Chaussabel, Uma Malhotra, William W. Kwok

Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial

Sergio Serrano-Villar, Talia Sainz, Zhong-Min Ma, Netanya S. Utay, Tae Wook-Chun, Surinder Mann, Angela D. Kashuba, Basile Siewe, Anthony Albanese, Paolo Troia-Cancio, Elizabeth Sinclair, Anoma Somasunderam, Tammy Yotter, Steven G. Deeks, Alan Landay, Richard B. Pollard, Christopher J. Miller, Santiago Moreno, David M. Asmuth

Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1)

Fengjuan Zhang, Donghai Peng, Chunsheng Cheng, Wei Zhou, Shouyong Ju, Danfeng Wan, Ziquan Yu, Jianwei Shi, Yaoyao Deng, Fenshan Wang, Xiaobo Ye, Zhenfei Hu, Jian Lin, Lifang Ruan, Ming Sun

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

Alicja Puchta, Avee Naidoo, Chris P. Verschoor, Dessi Loukov, Netusha Thevaranjan, Talveer S. Mandur, Phuong-son Nguyen, Manel Jordana, Mark Loeb, Zhou Xing, Lester Kobzik, Maggie J. Larché, Dawn M. E. Bowdish

Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort

Elise Landais, Xiayu Huang, Colin Havenar-Daughton, Ben Murrell, Matt A. Price, Lalinda Wickramasinghe, Alejandra Ramos, Charoan B. Bian, Melissa Simek, Susan Allen, Etienne Karita, William Kilembe, Shabir Lakhi, Mubiana Inambao, Anatoli Kamali, Eduard J. Sanders, Omu Anzala, Vinodh Edward, Linda-Gail Bekker, Jianming Tang, Jill Gilmour, Sergei L. Kosakovsky-Pond, Pham Phung, Terri Wrin, Shane Crotty, Adam Godzik, Pascal Poignard

Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques

Ivona Pandrea, Cuiling Xu, Jennifer L. Stock, Daniel N. Frank, Dongzhu Ma, Benjamin B. Policicchio, Tianyu He, Jan Kristoff, Elaine Cornell, George S. Haret-Richter, Anita Trichel, Ruy M. Ribeiro, Russell Tracy, Cara Wilson, Alan L. Landay, Cristian Apetrei

Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology

Marcela Montes de Oca, Rajiv Kumar, Fabian de Labastida Rivera, Fiona H Amante, Meru Sheel, Rebecca J. Faleiro, Patrick T. Bunn, Shannon E. Best, Lynette Beattie, Susanna S. Ng, Chelsea L. Edwards, Werner Muller, Erika Cretney, Stephen L. Nutt, Mark J. Smyth, Ashraful Haque, Geoffrey R. Hill, Shyam Sundar, Axel Kallies, Christian R. Engwerda

Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia

Gerco den Hartog, Ranajoy Chattopadhyay, Amber Ablack, Emily H. Hall, Lindsay D. Butcher, Asima Bhattacharyya, Lars Eckmann, Paul R. Harris, Soumita Das, Peter B. Ernst, Sheila E. Crowe

The Conoid Associated Motor MyoH Is Indispensable for Toxoplasma gondii Entry and Exit from Host Cells

Arnault Graindorge, Karine Frénal, Damien Jacot, Julien Salamun, Jean Baptiste Marq, Dominique Soldati-Favre

EBNA2 Drives Formation of New Chromosome Binding Sites and Target Genes for B-Cell Master Regulatory Transcription Factors RBP-jκ and EBF1

Fang Lu, Horng-Shen Chen, Andrew V. Kossenkov, Karen DeWispeleare, Kyoung-Jae Won, Paul M. Lieberman

Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis

Amanda J. Martinot, Mary Farrow, Lu Bai, Emilie Layre, Tan-Yun Cheng, Jennifer H. Tsai, Jahangir Iqbal, John W. Annand, Zuri A. Sullivan, M. Mahmood Hussain, James Sacchettini, D. Branch Moody, Jessica C. Seeliger, Eric J. Rubin

EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells

Jens S. Kalchschmidt, Adam C. T. Gillman, Kostas Paschos, Quentin Bazot, Bettina Kempkes, Martin J. Allday

Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control

Margaret E. Ackerman, Anastassia Mikhailova, Eric P. Brown, Karen G. Dowell, Bruce D. Walker, Chris Bailey-Kellogg, Todd J. Suscovich, Galit Alter

A Higher Activation Threshold of Memory CD8+ T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis

Stephen M. Carpenter, Cláudio Nunes-Alves, Matthew G. Booty, Sing Sing Way, Samuel M. Behar

A Trypanosomatid Iron Transporter that Regulates Mitochondrial Function Is Required for Leishmania amazonensis Virulence

Bidyottam Mittra, Maria Fernanda Laranjeira-Silva, Juliana Perrone Bezerra de Menezes, Jennifer Jensen, Vladimir Michailowsky, Norma W. Andrews

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

Glen M. Chew, Tsuyoshi Fujita, Gabriela M. Webb, Benjamin J. Burwitz, Helen L. Wu, Jason S. Reed, Katherine B. Hammond, Kiera L. Clayton, Naoto Ishii, Mohamed Abdel-Mohsen, Teri Liegler, Brooks I. Mitchell, Frederick M. Hecht, Mario Ostrowski, Cecilia M. Shikuma, Scott G. Hansen, Mark Maurer, Alan J. Korman, Steven G. Deeks, Jonah B. Sacha, Lishomwa C. Ndhlovu

Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication

Youichi Suzuki, Wei-Xin Chin, Qi'En Han, Koji Ichiyama, Ching Hua Lee, Zhi Wen Eyo, Hirotaka Ebina, Hirotaka Takahashi, Chikako Takahashi, Beng Hui Tan, Takayuki Hishiki, Kenji Ohba, Toshifumi Matsuyama, Yoshio Koyanagi, Yee-Joo Tan, Tatsuya Sawasaki, Justin Jang Hann Chu, Subhash G. Vasudevan, Kouichi Sano, Naoki Yamamoto

A Shift from Cellular to Humoral Responses Contributes to Innate Immune Memory in the Vector Snail Biomphalaria glabrata

Silvain Pinaud, Julien Portela, David Duval, Fanny C. Nowacki, Marie-Aude Olive, Jean-François Allienne, Richard Galinier, Nolwenn M. Dheilly, Sylvie Kieffer-Jaquinod, Guillaume Mitta, André Théron, Benjamin Gourbal

Lyn Delivers Bacteria to Lysosomes for Eradication through TLR2-Initiated Autophagy Related Phagocytosis

Xuefeng Li, Sisi He, Xikun Zhou, Yan Ye, Shirui Tan, Shuang Zhang, Rongpeng Li, Min Yu, Michael C. Jundt, Alec Hidebrand, Yongsheng Wang, Guoping Li, Canhua Huang, Min Wu

UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages

Min Zhang, Satish Mishra, Ramanavelan Sakthivel, Beatriz M. A. Fontoura, Victor Nussenzweig

HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT)

Keiko Yasuma, Jun-ichirou Yasunaga, Keiko Takemoto, Kenji Sugata, Yuichi Mitobe, Norihiro Takenouchi, Masanori Nakagawa, Yutaka Suzuki, Masao Matsuoka

A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation

Eoin N. Leen, Frédéric Sorgeloos, Samantha Correia, Yasmin Chaudhry, Fabien Cannac, Chiara Pastore, Yingqi Xu, Stephen C. Graham, Stephen J. Matthews, Ian G. Goodfellow, Stephen Curry

Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger

Ruben M. Markosyan, Chunhui Miao, Yi-Min Zheng, Gregory B. Melikyan, Shan-Lu Liu, Fredric S. Cohen

Functional Interplay between Type I and II Interferons Is Essential to Limit Influenza A Virus-Induced Tissue Inflammation

Sebastian A. Stifter, Nayan Bhattacharyya, Roman Pillay, Manuela Flórido, James A. Triccas, Warwick J. Britton, Carl G. Feng

Regulation of Life Cycle Checkpoints and Developmental Activation of Infective Larvae in Strongyloides stercoralis by Dafachronic Acid

Mennatallah M. Y. Albarqi, Jonathan D. Stoltzfus, Adeiye A. Pilgrim, Thomas J. Nolan, Zhu Wang, Steven A. Kliewer, David J. Mangelsdorf, James B. Lok

A Highly Conserved Bacterial D-Serine Uptake System Links Host Metabolism and Virulence

James P. R. Connolly, Mads Gabrielsen, Robert J. Goldstone, Rhys Grinter, Dai Wang, Richard J. Cogdell, Daniel Walker, David G. E. Smith, Andrew J. Roe

Papillomavirus-Associated Tumor Formation Critically Depends on c-Fos Expression Induced by Viral Protein E2 and Bromodomain Protein Brd4

Maria Delcuratolo, Jasmin Fertey, Markus Schneider, Johanna Schuetz, Natalie Leiprecht, Benjamin Hudjetz, Stephan Brodbeck, Silke Corall, Marcel Dreer, Roxana Michaela Schwab, Martin Grimm, Shwu-Yuan Wu, Frank Stubenrauch, Cheng-Ming Chiang, Thomas Iftner

Pseudomonas aeruginosa Transmigrates at Epithelial Cell-Cell Junctions, Exploiting Sites of Cell Division and Senescent Cell Extrusion

Guillaume Golovkine, Eric Faudry, Stéphanie Bouillot, Sylvie Elsen, Ina Attrée, Philippe Huber

Research Matters