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Table of Contents: October 2014

COVER

Encephalitozoon cuniculi.

Image Credit: Helen Springer-Frauenhoff
Issue Image

As a novel target organism of the cell-autonomous IRG resistance system, Jonathan Howard and colleagues identified the fungal parasite Encephalitozoon cuniculi, which while growing unrestricted incidentally formed here a heart-shaped vacuole with its spores (immunostained in red, DAPI blue). See Jonathan Howard and colleagues.

Pearls

Paracoccidioides Species Complex: Ecology, Phylogeny, Sexual Reproduction, and Virulence

Marcus M. Teixeira, Raquel C. Theodoro, Gustavo Nino-Vega, Eduardo Bagagli, Maria S. S. Felipe

Theory and Empiricism in Virulence Evolution

James J. Bull, Adam S. Lauring

Chrysosporium-Related Fungi and Reptiles: A Fatal Attraction

F. Javier Cabañes, Deanna A. Sutton, Josep Guarro

Review

Research Articles

The ESAT-6 Protein of Mycobacterium tuberculosis Interacts with Beta-2-Microglobulin (β2M) Affecting Antigen Presentation Function of Macrophage

Gopalkrishna Sreejit, Asma Ahmed, Nazia Parveen, Vishwanath Jha, Vijaya Lakshmi Valluri, Sudip Ghosh, Sangita Mukhopadhyay

Identification of the Microsporidian Encephalitozoon cuniculi as a New Target of the IFNγ-Inducible IRG Resistance System

Marialice da Fonseca Ferreira-da-Silva, Helen Maria Springer-Frauenhoff, Wolfgang Bohne, Jonathan C. Howard

Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly

Amanda J. Price, David A. Jacques, William A. McEwan, Adam J. Fletcher, Sebastian Essig, Jason W. Chin, Upul D. Halambage, Christopher Aiken, Leo C. James

CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells

Luca Micci, Xavier Alvarez, Robin I. Iriele, Alexandra M. Ortiz, Emily S. Ryan, Colleen S. McGary, Claire Deleage, Brigitte B. McAtee, Tianyu He, Cristian Apetrei, Kirk Easley, Savita Pahwa, Ronald G. Collman, Cynthia A. Derdeyn, Miles P. Davenport, Jacob D. Estes, Guido Silvestri, Andrew A. Lackner, Mirko Paiardini

Mycobacterium tuberculosis Lipoprotein LprG Binds Lipoarabinomannan and Determines Its Cell Envelope Localization to Control Phagolysosomal Fusion

Supriya Shukla, Edward T. Richardson, Jaffre J. Athman, Libin Shi, Pamela A. Wearsch, David McDonald, Niaz Banaei, W. Henry Boom, Mary Jackson, Clifford V. Harding

The N-Terminus of Murine Leukaemia Virus p12 Protein Is Required for Mature Core Stability

Darren J. Wight, Virginie C. Boucherit, Madushi Wanaguru, Efrat Elis, Elizabeth M. A. Hirst, Wilson Li, Marcelo Ehrlich, Eran Bacharach, Kate N. Bishop

One Small Step for a Yeast - Microevolution within Macrophages Renders Candida glabrata Hypervirulent Due to a Single Point Mutation

Sascha Brunke, Katja Seider, Daniel Fischer, Ilse D. Jacobsen, Lydia Kasper, Nadja Jablonowski, Anja Wartenberg, Oliver Bader, Adela Enache-Angoulvant, Martin Schaller, Christophe d'Enfert, Bernhard Hube

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

Kathrin Buffen, Marije Oosting, Jessica Quintin, Aylwin Ng, Johanneke Kleinnijenhuis, Vinod Kumar, Esther van de Vosse, Cisca Wijmenga, Reinout van Crevel, Egbert Oosterwijk, Anne J. Grotenhuis, Sita H. Vermeulen, Lambertus A. Kiemeney, Frank L. van de Veerdonk, Georgios Chamilos, Ramnik J. Xavier, Jos W. M. van der Meer, Mihai G. Netea, Leo A. B. Joosten

Chromobacterium Csp_P Reduces Malaria and Dengue Infection in Vector Mosquitoes and Has Entomopathogenic and In Vitro Anti-pathogen Activities

Jose Luis Ramirez, Sarah M. Short, Ana C. Bahia, Raul G. Saraiva, Yuemei Dong, Seokyoung Kang, Abhai Tripathi, Godfree Mlambo, George Dimopoulos

A Novel Function of Human Pumilio Proteins in Cytoplasmic Sensing of Viral Infection

Ryo Narita, Kiyohiro Takahasi, Etsu Murakami, Emi Hirano, Seiji P. Yamamoto, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita

Sensing of Immature Particles Produced by Dengue Virus Infected Cells Induces an Antiviral Response by Plasmacytoid Dendritic Cells

Elodie Décembre, Sonia Assil, Marine L. B. Hillaire, Wanwisa Dejnirattisai, Juthathip Mongkolsapaya, Gavin R. Screaton, Andrew D. Davidson, Marlène Dreux

Live Attenuated Francisella novicida Vaccine Protects against Francisella tularensis Pulmonary Challenge in Rats and Non-human Primates

Ping Chu, Aimee L. Cunningham, Jieh-Juen Yu, Jesse Q. Nguyen, Jeffrey R. Barker, C. Rick Lyons, Julie Wilder, Michelle Valderas, Robert L. Sherwood, Bernard P. Arulanandam, Karl E. Klose

Contact Heterogeneity, Rather Than Transmission Efficiency, Limits the Emergence and Spread of Canine Influenza Virus

Benjamin D. Dalziel, Kai Huang, Jemma L. Geoghegan, Nimalan Arinaminpathy, Edward J. Dubovi, Bryan T. Grenfell, Stephen P. Ellner, Edward C. Holmes, Colin R. Parrish

Kaposi's Sarcoma-Associated Herpesvirus Induces Nrf2 during De Novo Infection of Endothelial Cells to Create a Microenvironment Conducive to Infection

Olsi Gjyshi, Virginie Bottero, Mohanan Valliya Veettil, Sujoy Dutta, Vivek Vikram Singh, Leela Chikoti, Bala Chandran

HPV16-E7 Expression in Squamous Epithelium Creates a Local Immune Suppressive Environment via CCL2- and CCL5- Mediated Recruitment of Mast Cells

Anne-Sophie Bergot, Neill Ford, Graham R. Leggatt, James W. Wells, Ian H. Frazer, Michele A. Grimbaldeston

Listeria monocytogenes Dampens the DNA Damage Response

Ascel Samba-Louaka, Jorge M. Pereira, Marie-Anne Nahori, Veronique Villiers, Ludovic Deriano, Mélanie A. Hamon, Pascale Cossart

Candida albicans Ethanol Stimulates Pseudomonas aeruginosa WspR-Controlled Biofilm Formation as Part of a Cyclic Relationship Involving Phenazines

Annie I. Chen, Emily F. Dolben, Chinweike Okegbe, Colleen E. Harty, Yuriy Golub, Sandy Thao, Dae Gon Ha, Sven D. Willger, George A. O'Toole, Caroline S. Harwood, Lars E. P. Dietrich, Deborah A. Hogan

Co-opted Oxysterol-Binding ORP and VAP Proteins Channel Sterols to RNA Virus Replication Sites via Membrane Contact Sites

Daniel Barajas, Kai Xu, Isabel Fernández de Castro Martín, Zsuzsanna Sasvari, Federica Brandizzi, Cristina Risco, Peter D. Nagy

A Sialic Acid Binding Site in a Human Picornavirus

Georg Zocher, Nitesh Mistry, Martin Frank, Irmgard Hähnlein-Schick, Jens-Ola Ekström, Niklas Arnberg, Thilo Stehle

The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis

Margherita Bertuzzi, Markus Schrettl, Laura Alcazar-Fuoli, Timothy C. Cairns, Alberto Muñoz, Louise A. Walker, Susanne Herbst, Maryam Safari, Angela M. Cheverton, Dan Chen, Hong Liu, Shinobu Saijo, Natalie D. Fedorova, Darius Armstrong-James, Carol A. Munro, Nick D. Read, Scott G. Filler, Eduardo A. Espeso, William C. Nierman, Hubertus Haas, Elaine M. Bignell

Allele-Specific Induction of IL-1β Expression by C/EBPβ and PU.1 Contributes to Increased Tuberculosis Susceptibility

Guoliang Zhang, Boping Zhou, Shaoyuan Li, Jun Yue, Hui Yang, Yuxin Wen, Senlin Zhan, Wenfei Wang, Mingfeng Liao, Mingxia Zhang, Gucheng Zeng, Carl G. Feng, Christopher M. Sassetti, Xinchun Chen

Novel Cyclic di-GMP Effectors of the YajQ Protein Family Control Bacterial Virulence

Shi-qi An, Delphine L. Caly, Yvonne McCarthy, Sarah L. Murdoch, Joseph Ward, Melanie Febrer, J. Maxwell Dow, Robert P. Ryan

Human Cytomegalovirus Drives Epigenetic Imprinting of the IFNG Locus in NKG2Chi Natural Killer Cells

Merlin Luetke-Eversloh, Quirin Hammer, Pawel Durek, Karl Nordström, Gilles Gasparoni, Matthias Pink, Alf Hamann, Jörn Walter, Hyun-Dong Chang, Jun Dong, Chiara Romagnani

Involvement of a 1-Cys Peroxiredoxin in Bacterial Virulence

Gilberto Hideo Kaihami, José Roberto Fogaça de Almeida, Suelen Silvana dos Santos, Luis Eduardo Soares Netto, Sandro Rogério de Almeida, Regina Lúcia Baldini

Expression Profiling during Arabidopsis/Downy Mildew Interaction Reveals a Highly-Expressed Effector That Attenuates Responses to Salicylic Acid

Shuta Asai, Ghanasyam Rallapalli, Sophie J. M. Piquerez, Marie-Cécile Caillaud, Oliver J. Furzer, Naveed Ishaque, Lennart Wirthmueller, Georgina Fabro, Ken Shirasu, Jonathan D. G. Jones

Myosins VIII and XI Play Distinct Roles in Reproduction and Transport of Tobacco Mosaic Virus

Khalid Amari, Martin Di Donato, Valerian V. Dolja, Manfred Heinlein

The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration

Jennifer A. Gaddy, Jana N. Radin, John T. Loh, M. Blanca Piazuelo, Thomas E. Kehl-Fie, Alberto G. Delgado, Florin T. Ilca, Richard M. Peek, Timothy L. Cover, Walter J. Chazin, Eric P. Skaar, Holly M. Scott Algood

APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model

Kei Sato, Junko S. Takeuchi, Naoko Misawa, Taisuke Izumi, Tomoko Kobayashi, Yuichi Kimura, Shingo Iwami, Akifumi Takaori-Kondo, Wei-Shau Hu, Kazuyuki Aihara, Mamoru Ito, Dong Sung An, Vinay K. Pathak, Yoshio Koyanagi

Characteristics of Memory B Cells Elicited by a Highly Efficacious HPV Vaccine in Subjects with No Pre-existing Immunity

Erin M. Scherer, Robin A. Smith, Cassandra A. Simonich, Nixon Niyonzima, Joseph J. Carter, Denise A. Galloway

Interaction with Tsg101 Is Necessary for the Efficient Transport and Release of Nucleocapsids in Marburg Virus-Infected Cells

Olga Dolnik, Larissa Kolesnikova, Sonja Welsch, Thomas Strecker, Gordian Schudt, Stephan Becker

MicroRNAs Suppress NB Domain Genes in Tomato That Confer Resistance to Fusarium oxysporum

Shouqiang Ouyang, Gyungsoon Park, Hagop S. Atamian, Cliff S. Han, Jason E. Stajich, Isgouhi Kaloshian, Katherine A. Borkovich

Structural Basis for the Recognition of Human Cytomegalovirus Glycoprotein B by a Neutralizing Human Antibody

Nadja Spindler, Uschi Diestel, Joachim D. Stump, Anna-Katharina Wiegers, Thomas H. Winkler, Heinrich Sticht, Michael Mach, Yves A. Muller

Neutrophil Crawling in Capillaries; A Novel Immune Response to Staphylococcus aureus

Mark Geoffrey Harding, Kunyan Zhang, John Conly, Paul Kubes

Glutamate Secretion and Metabotropic Glutamate Receptor 1 Expression during Kaposi's Sarcoma-Associated Herpesvirus Infection Promotes Cell Proliferation

Mohanan Valiya Veettil, Dipanjan Dutta, Virginie Bottero, Chirosree Bandyopadhyay, Olsi Gjyshi, Neelam Sharma-Walia, Sujoy Dutta, Bala Chandran

Leishmania donovani Infection Causes Distinct Epigenetic DNA Methylation Changes in Host Macrophages

Alexandra K. Marr, Julia L. MacIsaac, Ruiwei Jiang, Adriana M. Airo, Michael S. Kobor, W. Robert McMaster

mRNA Structural Constraints on EBNA1 Synthesis Impact on In Vivo Antigen Presentation and Early Priming of CD8+ T Cells

Judy T. Tellam, Jie Zhong, Lea Lekieffre, Purnima Bhat, Michelle Martinez, Nathan P. Croft, Warren Kaplan, Ross L. Tellam, Rajiv Khanna

Vaginal Challenge with an SIV-Based Dual Reporter System Reveals That Infection Can Occur throughout the Upper and Lower Female Reproductive Tract

Daniel J. Stieh, Danijela Maric, Z. L. Kelley, Meegan R. Anderson, Holly Z. Hattaway, Beth A. Beilfuss, Katharina B. Rothwangl, Ronald S. Veazey, Thomas J. Hope

Agrobacterium Uses a Unique Ligand-Binding Mode for Trapping Opines and Acquiring A Competitive Advantage in the Niche Construction on Plant Host

Julien Lang, Armelle Vigouroux, Sara Planamente, Abbas El Sahili, Pauline Blin, Magali Aumont-Nicaise, Yves Dessaux, Solange Moréra, Denis Faure

Antimicrobials, Stress and Mutagenesis

Alexandro Rodríguez-Rojas, Olga Makarova, Jens Rolff

Dengue Viruses Are Enhanced by Distinct Populations of Serotype Cross-Reactive Antibodies in Human Immune Sera

Ruklanthi de Alwis, Katherine L. Williams, Michael A. Schmid, Chih-Yun Lai, Bhumi Patel, Scott A. Smith, James E. Crowe, Wei-Kung Wang, Eva Harris, Aravinda M. de Silva

Insights into Vibrio cholerae Intestinal Colonization from Monitoring Fluorescently Labeled Bacteria

Yves A. Millet, David Alvarez, Simon Ringgaard, Ulrich H. von Andrian, Brigid M. Davis, Matthew K. Waldor

A Relay Network of Extracellular Heme-Binding Proteins Drives C. albicans Iron Acquisition from Hemoglobin

Galit Kuznets, Elena Vigonsky, Ziva Weissman, Daniela Lalli, Tsvia Gildor, Sarah J. Kauffman, Paola Turano, Jeffrey Becker, Oded Lewinson, Daniel Kornitzer

Epstein-Barr Virus Nuclear Antigen 3A Promotes Cellular Proliferation by Repression of the Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1

Melissa L. Tursiella, Emily R. Bowman, Keith C. Wanzeck, Robert E. Throm, Jason Liao, Junjia Zhu, Clare E. Sample

HIV Acquisition Is Associated with Increased Antimicrobial Peptides and Reduced HIV Neutralizing IgA in the Foreskin Prepuce of Uncircumcised Men

Taha Hirbod, Xiangrong Kong, Godgrey Kigozi, Anthony Ndyanabo, David Serwadda, Jessica L. Prodger, Aaron A. Tobian, Fred Nalugoda, Maria J. Wawer, Kamnoosh Shahabi, Olga L. Rojas, Jennifer L. Gommerman, Kristina Broliden, Rupert Kaul, Ronald H. Gray

Characterization of Uncultivable Bat Influenza Virus Using a Replicative Synthetic Virus

Bin Zhou, Jingjiao Ma, Qinfang Liu, Bhupinder Bawa, Wei Wang, Reed S. Shabman, Michael Duff, Jinhwa Lee, Yuekun Lang, Nan Cao, Abdou Nagy, Xudong Lin, Timothy B. Stockwell, Juergen A. Richt, David E. Wentworth, Wenjun Ma

Cyclophilin A Associates with Enterovirus-71 Virus Capsid and Plays an Essential Role in Viral Infection as an Uncoating Regulator

Jie Qing, Yaxin Wang, Yuna Sun, Jiaoyan Huang, Wenzhong Yan, Jinglan Wang, Dan Su, Cheng Ni, Jian Li, Zihe Rao, Lei Liu, Zhiyong Lou

Mycobacterial Antigen Driven Activation of CD14++CD16 Monocytes Is a Predictor of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome

Bruno B. Andrade, Amrit Singh, Gopalan Narendran, Melissa E. Schechter, Kaustuv Nayak, Sudha Subramanian, Selvaraj Anbalagan, Stig M. R. Jensen, Brian O. Porter, Lis R. Antonelli, Katalin A. Wilkinson, Robert J. Wilkinson, Graeme Meintjes, Helen van der Plas, Dean Follmann, Daniel L. Barber, Soumya Swaminathan, Alan Sher, Irini Sereti

Corrections