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Table of Contents: August 2010

Issue Image

Epifluorescence micrograph of the murine urinary bladder epithelium during chronic bacterial cystitis with uropathogenic E. coli (UPEC). The image demonstrates the ongoing bladder epithelial inflammation (epithelial and immune cell nuclei are counterstained blue and epithelial cells autofluoresce green) after 4 weeks of UPEC infection. Bacteria appear yellow-orange due to indirect antibody co-staining with anti-E. coli (red) and anti-FimH for type 1 pili (green). Persistent extracellular colonization of the bladder with UPEC and accompanying chronic inflammatory responses induce changes to the bladder wall that persist long after clearance of infection with antibiotics and leave mice vulnerable to severe recurrent UTI (see Hannan et al., doi:10.1371/journal.ppat.1001042).

Opinion

Pearls

Reviews

Insecticide Control of Vector-Borne Diseases: When Is Insecticide Resistance a Problem?

Ana Rivero, Julien Vézilier, Mylène Weill, Andrew F. Read, Sylvain Gandon

Research Articles

A Novel CCR5 Mutation Common in Sooty Mangabeys Reveals SIVsmm Infection of CCR5-Null Natural Hosts and Efficient Alternative Coreceptor Use In Vivo

Nadeene E. Riddick, Emilia A. Hermann, Lamorris M. Loftin, Sarah T. Elliott, Winston C. Wey, Barbara Cervasi, Jessica Taaffe, Jessica C. Engram, Bing Li, James G. Else, Yingying Li, Beatrice H. Hahn, Cynthia A. Derdeyn, Donald L. Sodora, Cristian Apetrei, Mirko Paiardini, Guido Silvestri, Ronald G. Collman

Burkholderia Type VI Secretion Systems Have Distinct Roles in Eukaryotic and Bacterial Cell Interactions

Sandra Schwarz, T. Eoin West, Frédéric Boyer, Wen-Chi Chiang, Mike A. Carl, Rachel D. Hood, Laurence Rohmer, Tim Tolker-Nielsen, Shawn J. Skerrett, Joseph D. Mougous

PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

Shantelle L. LaFayette, Cathy Collins, Aimee K. Zaas, Wiley A. Schell, Marisol Betancourt-Quiroz, A. A. Leslie Gunatilaka, John R. Perfect, Leah E. Cowen

Chitin Synthases from Saprolegnia Are Involved in Tip Growth and Represent a Potential Target for Anti-Oomycete Drugs

Gea Guerriero, Mariano Avino, Qi Zhou, Johanna Fugelstad, Pierre-Henri Clergeot, Vincent Bulone

UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii

Mariane B. Melo, Pia Kasperkovitz, Anna Cerny, Stephanie Könen-Waisman, Evelyn A. Kurt-Jones, Egil Lien, Bruce Beutler, Jonathan C. Howard, Douglas T. Golenbock, Ricardo T. Gazzinelli

A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

Rubén Agudo, Cristina Ferrer-Orta, Armando Arias, Ignacio de la Higuera, Celia Perales, Rosa Pérez-Luque, Nuria Verdaguer, Esteban Domingo

Global Genotype-Phenotype Correlations in Pseudomonas aeruginosa

Claudia Pommerenke, Mathias Müsken, Tanja Becker, Andreas Dötsch, Frank Klawonn, Susanne Häussler

Distinct Merkel Cell Polyomavirus Molecular Features in Tumour and Non Tumour Specimens from Patients with Merkel Cell Carcinoma

Hélène C. Laude, Barbara Jonchère, Eve Maubec, Agnès Carlotti, Eduardo Marinho, Benoit Couturaud, Martine Peter, Xavier Sastre-Garau, Marie-Françoise Avril, Nicolas Dupin, Flore Rozenberg

Host Imprints on Bacterial Genomes—Rapid, Divergent Evolution in Individual Patients

Jaroslaw Zdziarski, Elzbieta Brzuszkiewicz, Björn Wullt, Heiko Liesegang, Dvora Biran, Birgit Voigt, Jenny Grönberg-Hernandez, Bryndis Ragnarsdottir, Michael Hecker, Eliora Z. Ron, Rolf Daniel, Gerhard Gottschalk, Jörg Hacker, Catharina Svanborg, Ulrich Dobrindt

Characterization of Oseltamivir-Resistant 2009 H1N1 Pandemic Influenza A Viruses

Maki Kiso, Kyoko Shinya, Masayuki Shimojima, Ryo Takano, Kei Takahashi, Hiroaki Katsura, Satoshi Kakugawa, Mai thi Quynh Le, Makoto Yamashita, Yousuke Furuta, Makoto Ozawa, Yoshihiro Kawaoka

The Synthetic Bacterial Lipopeptide Pam3CSK4 Modulates Respiratory Syncytial Virus Infection Independent of TLR Activation

D. Tien Nguyen, Lot de Witte, Martin Ludlow, Selma Yüksel, Karl-Heinz Wiesmüller, Teunis B. H. Geijtenbeek, Albert D. M. E. Osterhaus, Rik L. de Swart

Contribution of Herpesvirus Specific CD8 T Cells to Anti-Viral T Cell Response in Humans

Elena Sandalova, Diletta Laccabue, Carolina Boni, Anthony T. Tan, Katja Fink, Eng Eong Ooi, Robert Chua, Bahar Shafaeddin Schreve, Carlo Ferrari, Antonio Bertoletti

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

Jacob D. Estes, Levelle D. Harris, Nichole R. Klatt, Brian Tabb, Stefania Pittaluga, Mirko Paiardini, G. Robin Barclay, Jeremy Smedley, Rhonda Pung, Kenneth M. Oliveira, Vanessa M. Hirsch, Guido Silvestri, Daniel C. Douek, Christopher J. Miller, Ashley T. Haase, Jeffrey Lifson, Jason M. Brenchley

HIV-1 Populations in Semen Arise through Multiple Mechanisms

Jeffrey A. Anderson, Li-Hua Ping, Oliver Dibben, Cassandra B. Jabara, Leslie Arney, Laura Kincer, Yuyang Tang, Marcia Hobbs, Irving Hoffman, Peter Kazembe, Corbin D. Jones, Persephone Borrow, Susan Fiscus, Myron S. Cohen, Ronald Swanstrom , and the Center for HIV/AIDS Vaccine Immunology

Structural Alterations in a Component of Cytochrome c Oxidase and Molecular Evolution of Pathogenic Neisseria in Humans

Marina Aspholm, Finn Erik Aas, Odile B. Harrison, Diana Quinn, Åshild Vik, Raimonda Viburiene, Tone Tønjum, James Moir, Martin C. J. Maiden, Michael Koomey

Enterohemorrhagic E. coli Requires N-WASP for Efficient Type III Translocation but Not for EspFU-Mediated Actin Pedestal Formation

Didier Vingadassalom, Kenneth G. Campellone, Michael J. Brady, Brian Skehan, Scott E. Battle, Douglas Robbins, Archana Kapoor, Gail Hecht, Scott B. Snapper, John M. Leong

Giardia Cyst Wall Protein 1 Is a Lectin That Binds to Curled Fibrils of the GalNAc Homopolymer

Aparajita Chatterjee, Andrea Carpentieri, Daniel M. Ratner, Esther Bullitt, Catherine E. Costello, Phillips W. Robbins, John Samuelson

A Rapid Change in Virulence Gene Expression during the Transition from the Intestinal Lumen into Tissue Promotes Systemic Dissemination of Salmonella

Sebastian E. Winter, Maria G. Winter, Ivan Godinez, Hee-Jeong Yang, Holger Rüssmann, Helene L. Andrews-Polymenis, Andreas J. Bäumler

Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity

Laura M. J. Ylinen, Amanda J. Price, Jane Rasaiyaah, Stéphane Hué, Nicola J. Rose, Flavia Marzetta, Leo C. James, Greg J. Towers

Micro RNAs of Epstein-Barr Virus Promote Cell Cycle Progression and Prevent Apoptosis of Primary Human B Cells

Eri Seto, Andreas Moosmann, Sebastian Grömminger, Nicole Walz, Adam Grundhoff, Wolfgang Hammerschmidt

Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

Sophie A. Valkenburg, Stephanie Gras, Carole Guillonneau, Nicole L. La Gruta, Paul G. Thomas, Anthony W. Purcell, Jamie Rossjohn, Peter C. Doherty, Stephen J. Turner, Katherine Kedzierska

Early Severe Inflammatory Responses to Uropathogenic E. coli Predispose to Chronic and Recurrent Urinary Tract Infection

Thomas J. Hannan, Indira U. Mysorekar, Chia S. Hung, Megan L. Isaacson-Schmid, Scott J. Hultgren

The Pneumococcal Serine-Rich Repeat Protein Is an Intra-Species Bacterial Adhesin That Promotes Bacterial Aggregation In Vivo and in Biofilms

Carlos J. Sanchez, Pooja Shivshankar, Kim Stol, Samuel Trakhtenbroit, Paul M. Sullam, Karin Sauer, Peter W. M. Hermans, Carlos J. Orihuela

Tip-DC Development during Parasitic Infection Is Regulated by IL-10 and Requires CCL2/CCR2, IFN-γ and MyD88 Signaling

Tom Bosschaerts, Martin Guilliams, Benoît Stijlemans, Yannick Morias, Daniel Engel, Frank Tacke, Michel Hérin, Patrick De Baetselier, Alain Beschin

Kaposin-B Enhances the PROX1 mRNA Stability during Lymphatic Reprogramming of Vascular Endothelial Cells by Kaposi's Sarcoma Herpes Virus

Jaehyuk Yoo, Jinjoo Kang, Ha Neul Lee, Berenice Aguilar, Darren Kafka, Sunju Lee, Inho Choi, Juneyong Lee, Swapnika Ramu, Juergen Haas, Chester J. Koh, Young-Kwon Hong

Bacteriophage Lysin Mediates the Binding of Streptococcus mitis to Human Platelets through Interaction with Fibrinogen

Ho Seong Seo, Yan Q. Xiong, Jennifer Mitchell, Ravin Seepersaud, Arnold S. Bayer, Paul M. Sullam

CTCF Prevents the Epigenetic Drift of EBV Latency Promoter Qp

Italo Tempera, Andreas Wiedmer, Jayaraju Dheekollu, Paul M. Lieberman

A Limited Number of Antibody Specificities Mediate Broad and Potent Serum Neutralization in Selected HIV-1 Infected Individuals

Laura M. Walker, Melissa D. Simek, Frances Priddy, Johannes S. Gach, Denise Wagner, Michael B. Zwick, Sanjay K. Phogat, Pascal Poignard, Dennis R. Burton

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

Shinya Yamada, Masato Hatta, Bart L. Staker, Shinji Watanabe, Masaki Imai, Kyoko Shinya, Yuko Sakai-Tagawa, Mutsumi Ito, Makoto Ozawa, Tokiko Watanabe, Saori Sakabe, Chengjun Li, Jin Hyun Kim, Peter J. Myler, Isabelle Phan, Amy Raymond, Eric Smith, Robin Stacy, Chairul A. Nidom, Simon M. Lank, Roger W. Wiseman, Benjamin N. Bimber, David H. O'Connor, Gabriele Neumann, Lance J. Stewart, Yoshihiro Kawaoka

The Transcription Factor Rbf1 Is the Master Regulator for b-Mating Type Controlled Pathogenic Development in Ustilago maydis

Kai Heimel, Mario Scherer, Miroslav Vranes, Ramon Wahl, Chetsada Pothiratana, David Schuler, Volker Vincon, Florian Finkernagel, Ignacio Flor-Parra, Jörg Kämper

Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity

Alice G. Cheng, Molly McAdow, Hwan K. Kim, Taeok Bae, Dominique M. Missiakas, Olaf Schneewind

Spliced Leader Trapping Reveals Widespread Alternative Splicing Patterns in the Highly Dynamic Transcriptome of Trypanosoma brucei

Daniel Nilsson, Kapila Gunasekera, Jan Mani, Magne Osteras, Laurent Farinelli, Loic Baerlocher, Isabel Roditi, Torsten Ochsenreiter