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Identification of complexes of streptococcal M1 protein, IgG, and fibrinogen in a tissue biopsy obtained from a patient with severe Streptococcus pyogenes infection.
Specific IgG antibodies against the M1 protein were demonstrated to give rise to large complexes containing M1 protein (yellow), fibrinogen (magenta), and IgG (green). Such complexes promote a massive release of heparin-binding protein, which is an important inducer of vascular leakage and chock. Hence, antibodies against a bacterial antigen were found to contribute to a life-threatening inflammatory response (see Kahn et al., doi:10.1371/journal.ppat.1000149).
Image Credit: Anette Hofmann and Anna Norrby-Teglund, Karolinska Institutet.
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