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Table of Contents | January 2009

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Effector protein recruitment to vacuoles containing Legionella pneumophila.

The intracellular pathogen L. pneumophila infects eukaryotic cells and replicates in an endoplasmic reticulum-derived vacuole. Bacterial effector proteins translocated into host cells by a type IV secretion system called Dot/Icm control vacuole maturation. Regulation of distinct maturation events involves the spatial and temporal association of effector proteins with the vacuole. This image shows recruitment of the effector protein PieA (green) to vacuoles containing replicating L. pneumophila (blue rods). The authors demonstrate a unique mechanism for PieA recruitment to the mature L. pneumophila vacuole that requires protein modification to the vacuole membrane mediated by other L. pneumophila effectors (see Ninio et al., doi:10.1371/journal.ppat.1000278).

Image Credit: Shira Ninio, Yale University School of Medicine

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