Journal Archive
This archive contains links to the full-text of all issues of PLoS Pathogens.
Current Issue
About This Image
Fungipod protrusions on human immature dendritic cells.Dendritic cells use the C-type lectin CD206 (Mannose Receptor) to recognize fungal cells. Neumann and Jacobson (doi:10.1371/journal.ppat.1000760) report the discovery of the fungipod, a novel protrusive structure triggered on dendritic cells after CD206 engagement by yeast. Fungipods are long, conical motile structures with abundant F-actin, as shown in this projection image of a phalloidin-stained dendritic cell bearing several fungipods. Both S. cerevisiae and some pathogenic Candida species induce fungipods.
Image Credit: Aaron K. Neumann and Ken Jacobson, University of North Carolina, Chapel Hill