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Research Article

Varicellovirus UL49.5 Proteins Differentially Affect the Function of the Transporter Associated with Antigen Processing, TAP

  • Danijela Koppers-Lalic equal contributor,

    equal contributor Contributed equally to this work with: Danijela Koppers-Lalic, Marieke C. Verweij

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

    Current address: Virus and Stem Cell Biology Lab, Department of Molecular Cell Biology, Leiden University Medical Center, The Netherlands

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  • Marieke C. Verweij equal contributor,

    equal contributor Contributed equally to this work with: Danijela Koppers-Lalic, Marieke C. Verweij

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Andrea D. Lipińska,

    Affiliation: Department of Molecular Virology, University of Gdańsk, Gdańsk, Poland

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  • Ying Wang,

    Affiliation: Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America

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  • Edwin Quinten,

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Eric A. Reits,

    Affiliation: Department of Cell Biology and Histology, Academic Medical Centre, Amsterdam, The Netherlands

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  • Joachim Koch,

    Affiliation: Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Frankfurt/Main, Germany

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  • Sandra Loch,

    Affiliation: Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Frankfurt/Main, Germany

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  • Marisa Marcondes Rezende,

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Franz Daus,

    Affiliation: Virus Discovery Unit, ASG-Lelystad, Lelystad, The Netherlands

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  • Krystyna Bieńkowska-Szewczyk,

    Affiliation: Department of Molecular Virology, University of Gdańsk, Gdańsk, Poland

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  • Nikolaus Osterrieder,

    Affiliations: Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America, Institute for Virology, Berlin, Germany

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  • Thomas C. Mettenleiter,

    Affiliation: Institute of Molecular Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

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  • Mirjam H. M. Heemskerk,

    Affiliation: Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands

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  • Robert Tampé,

    Affiliation: Institute of Biochemistry, Biocenter, Goethe-University Frankfurt, Frankfurt/Main, Germany

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  • Jacques J. Neefjes,

    Affiliation: Department of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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  • Shafiqul I. Chowdhury,

    Affiliation: Department of Diagnostic Medicine/Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, United States of America

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  • Maaike E. Ressing,

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Frans A. M. Rijsewijk,

    Affiliation: Virus Discovery Unit, ASG-Lelystad, Lelystad, The Netherlands

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  • Emmanuel J. H. J. Wiertz mail

    wiertz@lumc.nl

    Affiliation: Center of Infectious Diseases and Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

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  • Published: May 30, 2008
  • DOI: 10.1371/journal.ppat.1000080

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