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Research Article

RIG-I Mediates the Co-Induction of Tumor Necrosis Factor and Type I Interferon Elicited by Myxoma Virus in Primary Human Macrophages

  • Fuan Wang,

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada

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  • Xiujuan Gao,

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada

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  • John W. Barrett,

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada

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  • Qing Shao,

    Affiliation: Department of Anatomy & Cell Biology, The University of Western Ontario, London, Ontario, Canada

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  • Eric Bartee,

    Affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Mohamed R. Mohamed,

    Affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Masmudur Rahman,

    Affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Steve Werden,

    Affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Timothy Irvine,

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada

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  • Jingxin Cao,

    Affiliation: National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

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  • Gregory A. Dekaban,

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada

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  • Grant McFadden mail

    grantmcf@ufl.edu

    Affiliations: BioTherapeutics Research Group, Robarts Research Institute, London, Ontario, Canada, Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada, Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • Published: July 11, 2008
  • DOI: 10.1371/journal.ppat.1000099

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