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Research Article

Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

  • Luke Uebelhoer,

    Affiliation: Department of Medicine, Division of Infectious Diseases, Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Jin-Hwan Han,

    Affiliation: Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America

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  • Benoit Callendret,

    Affiliations: The Center for Vaccines and Immunity, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, United States of America, Deparment of Pediatrics, The Ohio State University, Columbus Ohio, United States of America

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  • Guaniri Mateu,

    Affiliation: Department of Medicine, Division of Infectious Diseases, Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Naglaa H. Shoukry,

    Affiliation: Department of Medicine, University of Montreal and Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM), Montréal, Québec, Canada

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  • Holly L. Hanson,

    Affiliation: Department of Medicine, Division of Infectious Diseases, Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Charles M. Rice,

    Affiliation: Laboratory of Virology and Infectious Disease, Center for the Study of Hepatitis C, The Rockefeller University, New York, New York, United States of America

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  • Christopher M. Walker,

    Affiliations: The Center for Vaccines and Immunity, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, United States of America, Deparment of Pediatrics, The Ohio State University, Columbus Ohio, United States of America

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  • Arash Grakoui mail

    arash.grakoui@emory.edu

    Affiliation: Department of Medicine, Division of Infectious Diseases, Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Published: September 05, 2008
  • DOI: 10.1371/journal.ppat.1000143

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