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Research Article

A Structural Model of the Staphylococcus aureus ClfA–Fibrinogen Interaction Opens New Avenues for the Design of Anti-Staphylococcal Therapeutics

  • Vannakambadi K. Ganesh equal contributor,

    equal contributor Contributed equally to this work with: Vannakambadi K. Ganesh, Jose J. Rivera

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • Jose J. Rivera equal contributor,

    equal contributor Contributed equally to this work with: Vannakambadi K. Ganesh, Jose J. Rivera

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    Current address: Department of Infectious Diseases and Employee Health, M. D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Emanuel Smeds,

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • Ya-Ping Ko,

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • M. Gabriela Bowden,

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • Elisabeth R. Wann,

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • Shivasankarappa Gurusiddappa,

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    Current address: Genomics and Proteomics Core Laboratory, Texas Children's Hospital, Houston, Texas, United States of America

    X
  • J. Ross Fitzgerald,

    Affiliation: Centre for Infectious Diseases, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, United Kingdom

    X
  • Magnus Höök mail

    mhook@ibt.tamhsc.edu

    Affiliation: Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A & M University Health Science Center, Houston, Texas, United States of America

    X
  • Published: November 28, 2008
  • DOI: 10.1371/journal.ppat.1000226

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