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Research Article

Severe Plasmodium falciparum Malaria Is Associated with Circulating Ultra-Large von Willebrand Multimers and ADAMTS13 Inhibition

  • Deirdre Larkin,

    Affiliation: Haemostasis Research Group, Trinity Centre for Health Sciences, Trinity College Dublin, Dublin, Ireland

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  • Bas de Laat,

    Affiliation: Sanquin, Amsterdam, The Netherlands

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  • P. Vince Jenkins,

    Affiliation: Haemostasis Research Group, Trinity Centre for Health Sciences, Trinity College Dublin, Dublin, Ireland

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  • James Bunn,

    Affiliations: Departments of Community Health and Paediatrics, College of Medicine, Blantyre, Malawi, School of Tropical Medicine, Liverpool, United Kingdom

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  • Alister G. Craig,

    Affiliation: School of Tropical Medicine, Liverpool, United Kingdom

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  • Virginie Terraube,

    Affiliation: Haemostasis Research Group, Trinity Centre for Health Sciences, Trinity College Dublin, Dublin, Ireland

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  • Roger J. S. Preston,

    Affiliation: Haemostasis Research Group, Trinity Centre for Health Sciences, Trinity College Dublin, Dublin, Ireland

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  • Cynthia Donkor,

    Affiliations: School of Tropical Medicine, Liverpool, United Kingdom, Komfo Anokye Teaching Hospital, Kumasi, Ghana

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  • George E. Grau,

    Affiliation: Department of Pathology, University of Sydney, Sydney, New South Wales, Australia

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  • Jan A. van Mourik,

    Affiliation: Sanquin, Amsterdam, The Netherlands

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  • James S. O'Donnell mail

    jodonne@tcd.ie

    Affiliations: Haemostasis Research Group, Trinity Centre for Health Sciences, Trinity College Dublin, Dublin, Ireland, National Centre for Hereditary Coagulation Disorders, St James's Hospital, Dublin, Ireland

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  • Published: March 20, 2009
  • DOI: 10.1371/journal.ppat.1000349

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