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Research Article

Immunogenicity and Protective Efficacy of a Live Attenuated H5N1 Vaccine in Nonhuman Primates

  • Shufang Fan,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Yuwei Gao,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Kyoko Shinya,

    Affiliation: The International Center for Medical Research and Treatment, Kobe University, Kobe, Japan

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  • Chris Kafai Li,

    Affiliation: MRC Human Immunology Unit, The Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom

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  • Yanbing Li,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Jianzhong Shi,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Yongping Jiang,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Yongbing Suo,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Tiegang Tong,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Gongxun Zhong,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Jiasheng Song,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Ying Zhang,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Guobin Tian,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Yuntao Guan,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Xiao-Ning Xu,

    Affiliation: MRC Human Immunology Unit, The Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom

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  • Zhigao Bu,

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Yoshihiro Kawaoka mail,

    kawaokay@svm.vetmed.wisc.edu (YK); hlchen1@yahoo.com (HC)

    Affiliations: The International Center for Medical Research and Treatment, Kobe University, Kobe, Japan, Division of Virology, Department of Microbiology and Immunology, and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Hualan Chen mail

    kawaokay@svm.vetmed.wisc.edu (YK); hlchen1@yahoo.com (HC)

    Affiliation: Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China

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  • Published: May 01, 2009
  • DOI: 10.1371/journal.ppat.1000409

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