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Research Article

NFATc1 Mediates Toll-Like Receptor-Independent Innate Immune Responses during Trypanosoma cruzi Infection

  • Hisako Kayama equal contributor,

    equal contributor Contributed equally to this work with: Hisako Kayama, Ritsuko Koga

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Ritsuko Koga equal contributor,

    equal contributor Contributed equally to this work with: Hisako Kayama, Ritsuko Koga

    Affiliation: Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

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  • Koji Atarashi,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Megumi Okuyama,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Taishi Kimura,

    Affiliation: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

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  • Tak W. Mak,

    Affiliation: Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada, and Department of Medical Biophysics, Advanced Medical Discovery Institute, University of Toronto, Toronto, Ontario Canada

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  • Satoshi Uematsu,

    Affiliations: WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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  • Shizuo Akira,

    Affiliations: WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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  • Hiroshi Takayanagi,

    Affiliation: Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

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  • Kenya Honda,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Masahiro Yamamoto,

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Kiyoshi Takeda mail

    ktakeda@ongene.med.osaka-u.ac.jp

    Affiliations: Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

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  • Published: July 17, 2009
  • DOI: 10.1371/journal.ppat.1000514

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