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Research Article

HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

  • Bastien Mangeat,

    Affiliations: Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Gustavo Gers-Huber,

    Affiliations: Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Martin Lehmann,

    Affiliations: Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Madeleine Zufferey,

    Affiliation: Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Jeremy Luban,

    Affiliation: Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Vincent Piguet mail

    vincent.piguet@unige.ch

    Affiliations: Department of Dermatology and Venereology, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland, Department of Microbiology and Molecular Medicine, University Hospitals and Medical School of Geneva, University of Geneva, Switzerland

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  • Published: September 04, 2009
  • DOI: 10.1371/journal.ppat.1000574

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