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Research Article

Inhibition of Adaptive Immune Responses Leads to a Fatal Clinical Outcome in SIV-Infected Pigtailed Macaques but Not Vervet African Green Monkeys

  • Jörn E. Schmitz equal contributor mail,

    equal contributor Contributed equally to this work with: Jörn E. Schmitz, Roland C. Zahn

    jschmitz@bidmc.harvard.edu (JES); vhirsch@niaid.nih.gov (VMH)

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Roland C. Zahn equal contributor,

    equal contributor Contributed equally to this work with: Jörn E. Schmitz, Roland C. Zahn

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Charles R. Brown,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, United States of America

    X
  • Melisa D. Rett,

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Ming Li,

    Affiliation: Laboratory for AIDS Vaccine Research and Development, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Haili Tang,

    Affiliation: Laboratory for AIDS Vaccine Research and Development, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Sarah Pryputniewicz,

    Affiliation: Division of Immunology, New England Primate Research Center, Southborough, Massachusetts, United States of America

    X
  • Russell A. Byrum,

    Affiliation: Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Amitinder Kaur,

    Affiliation: Division of Immunology, New England Primate Research Center, Southborough, Massachusetts, United States of America

    X
  • David C. Montefiori,

    Affiliation: Laboratory for AIDS Vaccine Research and Development, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Jonathan S. Allan,

    Affiliation: Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America

    X
  • Simoy Goldstein,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, United States of America

    X
  • Vanessa M. Hirsch mail

    jschmitz@bidmc.harvard.edu (JES); vhirsch@niaid.nih.gov (VMH)

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland, United States of America

    X
  • Published: December 11, 2009
  • DOI: 10.1371/journal.ppat.1000691

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