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Research Article

Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

  • Kevin N. Couper mail,

    kevin.couper@lshtm.ac.uk (KNC); brian.desouza@lshtm.ac.uk (JBdS)

    Affiliation: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Tom Barnes,

    Affiliations: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, Department of Immunology and Molecular Pathology, University College London Medical School, London, United Kingdom

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  • Julius C. R. Hafalla,

    Affiliation: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Valery Combes,

    Affiliation: Department of Pathology, University of Sydney, Camperdown, New South Wales, Australia

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  • Bernhard Ryffel,

    Affiliation: Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique, Orleans, France

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  • Thomas Secher,

    Affiliation: Molecular Immunology and Embryology, University of Orleans and Centre National de la Recherche Scientifique, Orleans, France

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  • Georges E. Grau,

    Affiliation: Department of Pathology, University of Sydney, Camperdown, New South Wales, Australia

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  • Eleanor M. Riley,

    Affiliation: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • J. Brian de Souza mail

    kevin.couper@lshtm.ac.uk (KNC); brian.desouza@lshtm.ac.uk (JBdS)

    Affiliations: Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom, Department of Immunology and Molecular Pathology, University College London Medical School, London, United Kingdom

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  • Published: January 29, 2010
  • DOI: 10.1371/journal.ppat.1000744

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