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Research Article

Direct Visualization by Cryo-EM of the Mycobacterial Capsular Layer: A Labile Structure Containing ESX-1-Secreted Proteins

  • Musa Sani equal contributor,

    equal contributor Contributed equally to this work with: Musa Sani, Edith N. G. Houben, Jeroen Geurtsen

    Affiliation: Division of Cell Biology-B6, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital (NKI-AVL), Amsterdam, the Netherlands

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  • Edith N. G. Houben equal contributor,

    equal contributor Contributed equally to this work with: Musa Sani, Edith N. G. Houben, Jeroen Geurtsen

    Affiliation: Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, the Netherlands

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  • Jeroen Geurtsen equal contributor,

    equal contributor Contributed equally to this work with: Musa Sani, Edith N. G. Houben, Jeroen Geurtsen

    Affiliation: Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, the Netherlands

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  • Jason Pierson,

    Affiliation: Division of Cell Biology-B6, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital (NKI-AVL), Amsterdam, the Netherlands

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  • Karin de Punder,

    Affiliation: Division of Cell Biology-B6, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital (NKI-AVL), Amsterdam, the Netherlands

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  • Maaike van Zon,

    Affiliation: Division of Cell Biology-B6, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital (NKI-AVL), Amsterdam, the Netherlands

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  • Brigitte Wever,

    Affiliation: Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, the Netherlands

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  • Sander R. Piersma,

    Affiliation: Department of Medical Oncology, VU University Medical Centre, Amsterdam, the Netherlands

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  • Connie R. Jiménez,

    Affiliation: Department of Medical Oncology, VU University Medical Centre, Amsterdam, the Netherlands

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  • Mamadou Daffé,

    Affiliation: CNRS, Institut de Pharmacologie et de Biologie Structurale, Département Mécanismes Moléculaires des Infections Mycobactériennes, Toulouse, France

    Current address: Université de Toulouse (Toulouse III), Toulouse, France

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  • Ben J. Appelmelk,

    Affiliation: Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, the Netherlands

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  • Wilbert Bitter,

    Affiliation: Department of Medical Microbiology and Infection Control, VU University Medical Centre, Amsterdam, the Netherlands

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  • Nicole van der Wel mail,

    n.vd.wel@nki.nl (NvdW); p.peters@nki.nl (PJP)

    Affiliation: Division of Cell Biology-B6, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital (NKI-AVL), Amsterdam, the Netherlands

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  • Peter J. Peters mail

    n.vd.wel@nki.nl (NvdW); p.peters@nki.nl (PJP)

    Affiliations: Division of Cell Biology-B6, Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital (NKI-AVL), Amsterdam, the Netherlands, Kavli Institute of Nanoscience, Delft University of Technology, Delft, the Netherlands

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  • Published: March 05, 2010
  • DOI: 10.1371/journal.ppat.1000794

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