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Research Article

Oxidation of Helix-3 Methionines Precedes the Formation of PK Resistant PrPSc

  • Tamar Canello,

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel

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  • Kati Frid,

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel

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  • Ronen Gabizon,

    Affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Jerusalem, Israel

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  • Silvia Lisa,

    Affiliation: Instituto Química-Física Rocasolano, Consejo Superior de Investigaciones Científicas, Madrid, Spain

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  • Assaf Friedler,

    Affiliation: Institute of Chemistry, The Hebrew University of Jerusalem, Safra Campus, Jerusalem, Israel

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  • Jackob Moskovitz,

    Affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, United States of America

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  • María Gasset,

    Affiliation: Instituto Química-Física Rocasolano, Consejo Superior de Investigaciones Científicas, Madrid, Spain

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  • Ruth Gabizon mail

    gabizonr@hadassah.org.il

    Affiliation: Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah University Hospital, Jerusalem, Israel

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  • Published: July 01, 2010
  • DOI: 10.1371/journal.ppat.1000977

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