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Research Article

Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

  • Kazuhide Onoguchi,

    Affiliations: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe Sakyo, Kyoto, Japan, Graduate School of Science and Engineering, Waseda University, Tokyo, Japan

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  • Koji Onomoto,

    Affiliation: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan

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  • Shiori Takamatsu,

    Affiliations: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe Sakyo, Kyoto, Japan

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  • Michihiko Jogi,

    Affiliations: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe Sakyo, Kyoto, Japan

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  • Azumi Takemura,

    Affiliation: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan

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  • Shiho Morimoto,

    Affiliation: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan

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  • Ilkka Julkunen,

    Affiliation: Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland

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  • Hideo Namiki,

    Affiliation: Graduate School of Science and Engineering, Waseda University, Tokyo, Japan

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  • Mitsutoshi Yoneyama,

    Affiliations: Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chuo-ku, Chiba, Japan, PRESTO, Japan Science and Technology Agency, Saitama, Japan

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  • Takashi Fujita mail

    tfujita@virus.kyoto-u.ac.jp

    Affiliations: Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe Sakyo, Kyoto, Japan

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  • Published: July 22, 2010
  • DOI: 10.1371/journal.ppat.1001012

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