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Research Article

Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

  • Sophie A. Valkenburg,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia

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  • Stephanie Gras,

    Affiliation: The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

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  • Carole Guillonneau,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia

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  • Nicole L. La Gruta,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia

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  • Paul G. Thomas,

    Affiliation: Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Anthony W. Purcell,

    Affiliation: Department of Biochemistry and Molecular Biology, the Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia

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  • Jamie Rossjohn,

    Affiliation: The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

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  • Peter C. Doherty,

    Affiliations: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia, Department of Immunology, St Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Stephen J. Turner,

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia

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  • Katherine Kedzierska mail

    kkedz@unimelb.edu.au

    Affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia

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  • Published: August 12, 2010
  • DOI: 10.1371/journal.ppat.1001039

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