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Research Article

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

  • Edel A. McNeela,

    Affiliation: Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    X
  • Áine Burke,

    Affiliation: Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    X
  • Daniel R. Neill,

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    X
  • Cathy Baxter,

    Affiliation: Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    X
  • Vitor E. Fernandes,

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    X
  • Daniela Ferreira,

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    X
  • Sarah Smeaton,

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    X
  • Rana El-Rachkidy,

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    X
  • Rachel M. McLoughlin,

    Affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    X
  • Andres Mori,

    Affiliation: Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    X
  • Barry Moran,

    Affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    X
  • Katherine A. Fitzgerald,

    Affiliation: Department of Medicine, University of Massachusetts, Worcester, Massachusetts, United States of America

    X
  • Jurg Tschopp,

    Affiliation: Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

    X
  • Virginie Pétrilli,

    Affiliation: Department of Biochemistry, University of Lausanne, Epalinges, Switzerland

    X
  • Peter W. Andrew,

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    X
  • Aras Kadioglu mail,

    ak13@le.ac.uk (AK); lavellee@tcd.ie (ECL)

    Affiliation: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

    X
  • Ed C. Lavelle mail

    ak13@le.ac.uk (AK); lavellee@tcd.ie (ECL)

    Affiliation: Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    X
  • Published: November 11, 2010
  • DOI: 10.1371/journal.ppat.1001191

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