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Research Article

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

  • Leonie Unterholzner equal contributor,

    equal contributor Contributed equally to this work with: Leonie Unterholzner, Rebecca P. Sumner

    Affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

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  • Rebecca P. Sumner equal contributor,

    equal contributor Contributed equally to this work with: Leonie Unterholzner, Rebecca P. Sumner

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

    X
  • Marcin Baran ,

    Affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

    X
  • Hongwei Ren ,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

    X
  • Daniel S. Mansur,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

    X
  • Nollaig M. Bourke,

    Affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

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  • Felix Randow,

    Affiliation: Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

    X
  • Geoffrey L. Smith ,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

    X
  • Andrew G. Bowie mail

    agbowie@tcd.ie

    Affiliation: School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

    X
  • Published: September 08, 2011
  • DOI: 10.1371/journal.ppat.1002247

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