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Research Article

Exhausted CD8 T Cells Downregulate the IL-18 Receptor and Become Unresponsive to Inflammatory Cytokines and Bacterial Co-infections

  • Jennifer T. Ingram,

    Affiliations: Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • John S. Yi,

    Affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

    Current address: Division of Surgical Science, Duke University Medical Center, Durham, North Carolina, United States of America.

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  • Allan J. Zajac mail

    azajac@uab.edu

    Affiliation: Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Published: September 29, 2011
  • DOI: 10.1371/journal.ppat.1002273

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