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Research Article

Inhibition of Apoptosis and NF-κB Activation by Vaccinia Protein N1 Occur via Distinct Binding Surfaces and Make Different Contributions to Virulence

  • Carlos Maluquer de Motes,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Samantha Cooray equal contributor,

    equal contributor Contributed equally to this work with: Samantha Cooray, Hongwei Ren

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

    Current address: Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom

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  • Hongwei Ren equal contributor,

    equal contributor Contributed equally to this work with: Samantha Cooray, Hongwei Ren

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

    X
  • Gabriel M. F. Almeida,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

    Current address: Laboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    X
  • Kieran McGourty,

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

    Current address: Centre for Molecular Microbiology and Infection, Imperial College London, London, United Kingdom

    X
  • Mohammad W. Bahar,

    Affiliation: The Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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  • David I. Stuart,

    Affiliations: The Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Science Division, Diamond Light Source, Didcot, United Kingdom

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  • Jonathan M. Grimes,

    Affiliations: The Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Science Division, Diamond Light Source, Didcot, United Kingdom

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  • Stephen C. Graham,

    Affiliation: The Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

    Current address: Cambridge Institute for Medical Research and Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

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  • Geoffrey L. Smith mail

    geoffrey.l.smith@imperial.ac.uk

    Affiliation: Department of Virology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Published: December 15, 2011
  • DOI: 10.1371/journal.ppat.1002430

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