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Research Article

The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate Immunity

  • Magali Bebien,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Mary E. Hensler,

    Affiliation: Department of Pediatrics and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, School of Medicine, La Jolla, California, United States of America

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  • Suzel Davanture,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Li-Chung Hsu,

    Affiliation: Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla, California, United States of America

    Current address: Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

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  • Michael Karin,

    Affiliation: Department of Pharmacology, University of California San Diego, School of Medicine, La Jolla, California, United States of America

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  • Jin Mo Park,

    Affiliation: Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

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  • Lena Alexopoulou,

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • George Y. Liu,

    Affiliation: Immunobiology Institute, Cedars-Sinai Medical Center, University of California Los Angeles, School of Medicine, Los Angeles, California, United States of America

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  • Victor Nizet,

    Affiliation: Department of Pediatrics and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, School of Medicine, La Jolla, California, United States of America

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  • Toby Lawrence mail

    lawrence@ciml.univ-mrs.fr

    Affiliations: Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France, Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France, Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France

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  • Published: July 19, 2012
  • DOI: 10.1371/journal.ppat.1002812

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