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Research Article

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

  • Rebecca M. DuBois,

    Affiliations: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • P. Jake Slavish,

    Affiliation: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Brandi M. Baughman,

    Affiliations: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Mi-Kyung Yun,

    Affiliation: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Ju Bao,

    Affiliation: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Richard J. Webby,

    Affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Thomas R. Webb,

    Affiliations: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Stephen W. White mail

    Stephen.White@stjude.org

    Affiliations: Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America, Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America

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  • Published: August 02, 2012
  • DOI: 10.1371/journal.ppat.1002830

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