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Research Article

A Unique Bivalent Binding and Inhibition Mechanism by the Yatapoxvirus Interleukin 18 Binding Protein

  • Brian Krumm,

    Affiliation: Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America

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  • Xiangzhi Meng,

    Affiliation: Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

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  • Zhixin Wang,

    Affiliation: Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America

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  • Yan Xiang equal contributor mail,

    equal contributor Contributed equally to this work with: Yan Xiang, Junpeng Deng

    xiangy@uthscsa.edu (YX); Junpeng.deng@okstate.edu (JD)

    Affiliation: Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

    X
  • Junpeng Deng equal contributor mail

    equal contributor Contributed equally to this work with: Yan Xiang, Junpeng Deng

    xiangy@uthscsa.edu (YX); Junpeng.deng@okstate.edu (JD)

    Affiliation: Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America

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  • Published: August 23, 2012
  • DOI: 10.1371/journal.ppat.1002876

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