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Research Article

Quantifying the Diversification of Hepatitis C Virus (HCV) during Primary Infection: Estimates of the In Vivo Mutation Rate

  • Ruy M. Ribeiro,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

    Current address: Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

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  • Hui Li,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Shuyi Wang,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Mark B. Stoddard,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Gerald H. Learn,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Bette T. Korber,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • Tanmoy Bhattacharya,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • Jeremie Guedj,

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • Erica H. Parrish,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Beatrice H. Hahn,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • George M. Shaw,

    Affiliation: Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Alan S. Perelson mail

    asp@lanl.gov

    Affiliation: Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

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  • Published: August 23, 2012
  • DOI: 10.1371/journal.ppat.1002881

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