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Research Article

Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope

  • S. Kyle Austin,

    Affiliation: Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

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  • Kimberly A. Dowd,

    Affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Bimmi Shrestha,

    Affiliation: Department of Medicine (Infectious Diseases), Washington University School of Medicine, Saint Louis, Missouri, United States of America

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  • Christopher A. Nelson,

    Affiliation: Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

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  • Melissa A. Edeling,

    Affiliation: Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

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  • Syd Johnson,

    Affiliation: MacroGenics, Rockville, Maryland, United States of America

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  • Theodore C. Pierson,

    Affiliation: Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Michael S. Diamond mail,

    diamond@borcim.wustl.edu (MSD); fremont@wustl.edu (DHF)

    Affiliations: Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Medicine (Infectious Diseases), Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

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  • Daved H. Fremont mail

    diamond@borcim.wustl.edu (MSD); fremont@wustl.edu (DHF)

    Affiliations: Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri, United States of America

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  • Published: October 04, 2012
  • DOI: 10.1371/journal.ppat.1002930

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