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Research Article

DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING

  • Sebastian Aguirre,

    Affiliation: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Ana M. Maestre,

    Affiliation: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Sarah Pagni,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Mount Sinai Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Jenish R. Patel,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Mount Sinai Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Timothy Savage,

    Affiliation: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Delia Gutman,

    Affiliation: Department of Cell Biology, University of Miami School of Medicine, Miami, Florida, United States of America

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  • Kevin Maringer,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom

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  • Dabeiba Bernal-Rubio,

    Affiliation: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Reed S. Shabman,

    Affiliation: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Viviana Simon,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Juan R. Rodriguez-Madoz,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain

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  • Lubbertus C. F. Mulder,

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Glen N. Barber,

    Affiliation: Department of Cell Biology, University of Miami School of Medicine, Miami, Florida, United States of America

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  • Ana Fernandez-Sesma mail

    ana.sesma@mssm.edu

    Affiliations: Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America, Mount Sinai Graduate School of Biological Sciences, Mount Sinai School of Medicine, New York City, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Mount Sinai School of Medicine, New York City, New York, United States of America

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  • Published: October 04, 2012
  • DOI: 10.1371/journal.ppat.1002934

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