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Research Article

De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

  • Carl A. Morrow,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Eugene Valkov,

    Affiliations: School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom, Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

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  • Anna Stamp,

    Affiliation: School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Eve W. L. Chow,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • I. Russel Lee,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Ania Wronski,

    Affiliation: School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Simon J. Williams,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Justine M. Hill,

    Affiliations: School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia, Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia

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  • Julianne T. Djordjevic,

    Affiliation: Centre for Infectious Diseases and Microbiology, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, New South Wales, Australia

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  • Ulrike Kappler,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Bostjan Kobe,

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia, Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

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  • James A. Fraser mail

    jafraser@uq.edu.au

    Affiliations: Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, Queensland, Australia, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland, Australia

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.ppat.1002957

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