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Research Article

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

  • Jamie J. Arnold mail,

    jja5@psu.edu (JJA); cec9@psu.edu (CEC)

    Affiliation: Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Suresh D. Sharma,

    Affiliation: Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Joy Y. Feng,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

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  • Adrian S. Ray,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

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  • Eric D. Smidansky,

    Affiliation: Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Maria L. Kireeva,

    Affiliation: Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland, United States of America

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  • Aesop Cho,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

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  • Jason Perry,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

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  • Jennifer E. Vela,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

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  • Yeojin Park,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

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  • Yili Xu,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

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  • Yang Tian,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

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  • Darius Babusis,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

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  • Ona Barauskus,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

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  • Blake R. Peterson,

    Affiliation: Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas, United States of America

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  • Averell Gnatt,

    Affiliation: Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

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  • Mikhail Kashlev,

    Affiliation: Frederick National Laboratory for Cancer Research, NCI, Frederick, Maryland, United States of America

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  • Weidong Zhong,

    Affiliation: Gilead Sciences, Inc., Foster City, California, United States of America

    Current address: Novartis Institutes for BioMedical Research, Emeryville, California, United States of America.

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  • Craig E. Cameron mail

    jja5@psu.edu (JJA); cec9@psu.edu (CEC)

    Affiliation: Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.ppat.1003030

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