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Research Article

Rapid Antigen Processing and Presentation of a Protective and Immunodominant HLA-B*27-restricted Hepatitis C Virus-specific CD8+ T-cell Epitope

  • Julia Schmidt,

    Affiliations: Department of Medicine II, University Hospital Freiburg, Freiburg, Germany, Faculty of Biology, University of Freiburg, Freiburg, Germany, Centre of Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany

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  • Astrid K. N. Iversen mail,

    astrid.iversen@ndcn.ox.ac.uk (AKNI); robert.thimme@uniklinik-freiburg.de (RT)

    Affiliation: Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, United Kingdom

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  • Stefan Tenzer,

    Affiliation: Institute of Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany

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  • Emma Gostick,

    Affiliation: Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

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  • David A. Price,

    Affiliation: Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

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  • Volker Lohmann,

    Affiliation: Department of Infectious Diseases, University of Heidelberg, Heidelberg, Germany

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  • Ute Distler,

    Affiliation: Institute of Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany

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  • Paul Bowness,

    Affiliations: Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom, Nuffield Department of Clinical Medicine, Oxford, United Kingdom

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  • Hansjörg Schild,

    Affiliation: Institute of Immunology, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany

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  • Hubert E. Blum,

    Affiliation: Department of Medicine II, University Hospital Freiburg, Freiburg, Germany

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  • Paul Klenerman,

    Affiliation: Nuffield Department of Clinical Medicine, Oxford, United Kingdom

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  • Christoph Neumann-Haefelin equal contributor,

    equal contributor Contributed equally to this work with: Christoph Neumann-Haefelin, Robert Thimme

    Affiliation: Department of Medicine II, University Hospital Freiburg, Freiburg, Germany

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  • Robert Thimme equal contributor mail

    equal contributor Contributed equally to this work with: Christoph Neumann-Haefelin, Robert Thimme

    astrid.iversen@ndcn.ox.ac.uk (AKNI); robert.thimme@uniklinik-freiburg.de (RT)

    Affiliation: Department of Medicine II, University Hospital Freiburg, Freiburg, Germany

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.ppat.1003042

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