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Research Article

Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism

  • Nicole M. Chumbler,

    Affiliation: Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Melissa A. Farrow,

    Affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Lynne A. Lapierre,

    Affiliation: Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Jeffrey L. Franklin,

    Affiliations: Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cell and Developmental Biology and the Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • David Haslam,

    Affiliation: Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • James R. Goldenring,

    Affiliations: Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cell and Developmental Biology and the Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • D. Borden Lacy mail

    borden.lacy@vanderbilt.edu

    Affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Published: December 06, 2012
  • DOI: 10.1371/journal.ppat.1003072

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